ChemicalBook > CAS DataBase List > 4-CHLORO-6-IODOQUINOLINE

4-CHLORO-6-IODOQUINOLINE

Product Name
4-CHLORO-6-IODOQUINOLINE
CAS No.
40107-07-1
Chemical Name
4-CHLORO-6-IODOQUINOLINE
Synonyms
BUTTPARK 89\01-03;4-CHLORO-6-IODOQUINOLINE;Quinoline, 4-chloro-6-iodo-
CBNumber
CB8446844
Molecular Formula
C9H5ClIN
Formula Weight
289.5
MOL File
40107-07-1.mol
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4-CHLORO-6-IODOQUINOLINE Property

Melting point:
138-140℃
Boiling point:
338℃
Density 
1.919
Flash point:
158℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.81±0.16(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C9H5ClIN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H
InChIKey
XPXHGYKMODLJBY-UHFFFAOYSA-N
SMILES
N1C2C(=CC(I)=CC=2)C(Cl)=CC=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC57757
Product name
4-Chloro-6-iodoquinoline
Packaging
250mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC57757
Product name
4-Chloro-6-iodoquinoline
Packaging
500mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC57757
Product name
4-Chloro-6-iodoquinoline
Packaging
1g
Price
$400
Updated
2021/12/16
Matrix Scientific
Product number
133547
Product name
4-Chloro-6-iodoquinoline
Purity
97%
Packaging
1g
Price
$432
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0366148
Product name
4-CHLORO-6-IODOQUINOLINE
Purity
95.00%
Packaging
5MG
Price
$495.14
Updated
2021/12/16
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4-CHLORO-6-IODOQUINOLINE Chemical Properties,Usage,Production

Uses

4-Chloro-6-iodoquinoline is a commonly used synthetic intermediate in the fields of medicine and materials science, and can be used for cross-coupling reactions to synthesize different diarylquinoline compounds.

Synthesis

342617-07-6

40107-07-1

The general procedure for the synthesis of 4-chloro-6-iodoquinoline from 6-iodo-4-hydroxyquinoline was as follows: 6-iodo-4-hydroxyquinoline (100 g, 369 mmol) was suspended in phosphorus oxychloride (POCl3, 340 mL, 3.7 mol) at room temperature. After 1 hour of reaction, the reaction mixture was concentrated. The concentrated residue was carefully placed in an ice water bath and neutralized with saturated sodium bicarbonate solution. The resulting brown suspension was filtered and the solid was washed with water (2 x 500 mL) and subsequently dried under vacuum overnight to afford 4-chloro-6-iodoquinoline as a brown solid (103 g, 92% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.88 (d, J = 4.8 Hz, 1H), 8.54 (d, J = 1.8 Hz, 1H), 8.15 (dd, J = 8.8, 2.0 Hz, 1H), 7.88 (d, J = 8.8 Hz, 1H), 7.82 (d, J = 4.8 Hz, 1H); mass spectrum (MS) showed m/z of 289.9 ([M + H]+).

References

[1] Patent: US2012/41024, 2012, A1. Location in patent: Page/Page column 8; 10; 16
[2] Patent: EP2566477, 2015, B1. Location in patent: Paragraph 0157; 0160
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 4867 - 4880
[4] Patent: WO2005/63739, 2005, A1. Location in patent: Page/Page column 64

4-CHLORO-6-IODOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-CHLORO-6-IODOQUINOLINE manufacturers

Career Henan Chemica Co
Product
4-CHLORO-6-IODOQUINOLINE 40107-07-1
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20ton
Release date
2020-10-28

40107-07-1, 4-CHLORO-6-IODOQUINOLINERelated Search:

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  • 4-CHLORO-6-IODOQUINOLINE
  • BUTTPARK 89\01-03
  • Quinoline, 4-chloro-6-iodo-
  • 40107-07-1
  • CHIRAL CHEMICALS