4-CHLORO-6-IODOQUINOLINE
- Product Name
- 4-CHLORO-6-IODOQUINOLINE
- CAS No.
- 40107-07-1
- Chemical Name
- 4-CHLORO-6-IODOQUINOLINE
- Synonyms
- BUTTPARK 89\01-03;4-CHLORO-6-IODOQUINOLINE;Quinoline, 4-chloro-6-iodo-
- CBNumber
- CB8446844
- Molecular Formula
- C9H5ClIN
- Formula Weight
- 289.5
- MOL File
- 40107-07-1.mol
4-CHLORO-6-IODOQUINOLINE Property
- Melting point:
- 138-140℃
- Boiling point:
- 338℃
- Density
- 1.919
- Flash point:
- 158℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.81±0.16(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C9H5ClIN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H
- InChIKey
- XPXHGYKMODLJBY-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(I)=CC=2)C(Cl)=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- FC57757
- Product name
- 4-Chloro-6-iodoquinoline
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FC57757
- Product name
- 4-Chloro-6-iodoquinoline
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FC57757
- Product name
- 4-Chloro-6-iodoquinoline
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 133547
- Product name
- 4-Chloro-6-iodoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $432
- Updated
- 2021/12/16
- Product number
- HCH0366148
- Product name
- 4-CHLORO-6-IODOQUINOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.14
- Updated
- 2021/12/16
4-CHLORO-6-IODOQUINOLINE Chemical Properties,Usage,Production
Uses
4-Chloro-6-iodoquinoline is a commonly used synthetic intermediate in the fields of medicine and materials science, and can be used for cross-coupling reactions to synthesize different diarylquinoline compounds.
Synthesis
342617-07-6
40107-07-1
The general procedure for the synthesis of 4-chloro-6-iodoquinoline from 6-iodo-4-hydroxyquinoline was as follows: 6-iodo-4-hydroxyquinoline (100 g, 369 mmol) was suspended in phosphorus oxychloride (POCl3, 340 mL, 3.7 mol) at room temperature. After 1 hour of reaction, the reaction mixture was concentrated. The concentrated residue was carefully placed in an ice water bath and neutralized with saturated sodium bicarbonate solution. The resulting brown suspension was filtered and the solid was washed with water (2 x 500 mL) and subsequently dried under vacuum overnight to afford 4-chloro-6-iodoquinoline as a brown solid (103 g, 92% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.88 (d, J = 4.8 Hz, 1H), 8.54 (d, J = 1.8 Hz, 1H), 8.15 (dd, J = 8.8, 2.0 Hz, 1H), 7.88 (d, J = 8.8 Hz, 1H), 7.82 (d, J = 4.8 Hz, 1H); mass spectrum (MS) showed m/z of 289.9 ([M + H]+).
References
[1] Patent: US2012/41024, 2012, A1. Location in patent: Page/Page column 8; 10; 16
[2] Patent: EP2566477, 2015, B1. Location in patent: Paragraph 0157; 0160
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 4867 - 4880
[4] Patent: WO2005/63739, 2005, A1. Location in patent: Page/Page column 64
4-CHLORO-6-IODOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-6-IODOQUINOLINE Suppliers
- Tel
- --
- Fax
- --
- info@activate-scientific.com
- Country
- Germany
- ProdList
- 2856
- Advantage
- 61
View Lastest Price from 4-CHLORO-6-IODOQUINOLINE manufacturers
- Product
- 4-CHLORO-6-IODOQUINOLINE 40107-07-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2020-10-28