Uses
ChemicalBook > CAS DataBase List > 2-Methyl-6-nitroaniline

2-Methyl-6-nitroaniline

Uses
Product Name
2-Methyl-6-nitroaniline
CAS No.
570-24-1
Chemical Name
2-Methyl-6-nitroaniline
Synonyms
2-AMINO-3-NITROTOLUENE;6-NITRO-O-TOLUIDINE;2-Amino-3-nitro toulene;NSC 286;NSC 52218;-6-nitroaniL;6-Nitro-o-tol;LABOTEST-BB LTBB000621;3-NITRO-2-AMINOTOLUENE;2-NITRO-6-METHYLANILINE
CBNumber
CB8457596
Molecular Formula
C7H8N2O2
Formula Weight
152.15
MOL File
570-24-1.mol
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2-Methyl-6-nitroaniline Property

Melting point:
93-96 °C (lit.)
Boiling point:
124 °C / 1mmHg
Density 
1.19 g/cm3
refractive index 
1.6276 (estimate)
Flash point:
110 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
<1mg/l
pka
-0.44±0.25(Predicted)
form 
Crystalline Powder
color 
Brownish
Water Solubility 
<0.1 g/100 mL at 23 ºC
BRN 
1868029
CAS DataBase Reference
570-24-1(CAS DataBase Reference)
NIST Chemistry Reference
2-Methyl-6-nitroaniline(570-24-1)
EPA Substance Registry System
2-Methyl-6-nitroaniline (570-24-1)
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Safety

Hazard Codes 
T,N,Xi
Risk Statements 
23/24/25-33-51/53
Safety Statements 
28-36/37-45-61-28A
RIDADR 
UN 2660 6.1/PG 3
WGK Germany 
3
F 
10
Hazard Note 
Toxic
HazardClass 
6.1
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29214300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M59408
Product name
2-Methyl-6-nitroaniline
Purity
99%
Packaging
10g
Price
$77.9
Updated
2025/07/31
Sigma-Aldrich
Product number
M59408
Product name
2-Methyl-6-nitroaniline
Purity
99%
Packaging
100g
Price
$674
Updated
2023/06/20
TCI Chemical
Product number
N0467
Product name
2-Methyl-6-nitroaniline
Purity
>99.0%(GC)
Packaging
25g
Price
$129
Updated
2025/07/31
TCI Chemical
Product number
N0467
Product name
2-Methyl-6-nitroaniline
Purity
>99.0%(GC)
Packaging
250g
Price
$455
Updated
2025/07/31
TRC
Product number
M323560
Product name
2-Methyl-6-nitroaniline
Packaging
5g
Price
$50
Updated
2021/12/16
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2-Methyl-6-nitroaniline Chemical Properties,Usage,Production

Uses

2-Methyl-6-nitroaniline is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing.

Chemical Properties

Redish-Brown Solid

Uses

2-Methyl-6-nitroaniline (cas# 570-24-1) is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing

General Description

Orange-yellow prisms or brown granular powder.

Air & Water Reactions

2-Methyl-6-nitroaniline is sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

2-Methyl-6-nitroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizers.

Fire Hazard

Flash point data for 2-Methyl-6-nitroaniline are not available, but 2-Methyl-6-nitroaniline is probably combustible.

Synthesis

120-66-1

570-24-1

The general procedure for the synthesis of 2-methyl-6-nitroaniline from 2-methylacetanilide was carried out as follows: the modified Howard method [27] was used. Toluidine (1a or 1b; 53.5 mL, 0.5 mol) was slowly added to acetic anhydride (325 mL) in batches while maintaining constant stirring. The reaction solution was cooled to 12-13 °C in an ice-salt bath. Subsequently, 70% nitric acid (63 mL) was slowly added dropwise to the reaction mixture at a rate that maintained the temperature at 10-12 °C with constant stirring. The dropwise addition process took 2.5 h to complete, after which the solution was poured into 1.5 L of ice water. The resulting acetamide (3a, or a mixture of 3b and 3c) precipitate (as a cream-colored solid) was collected on a Brinell's funnel, washed with four 250 mL portions of ice water, and partially dried by suction. The wetted acetamide (3a, or a mixture of 3b and 3c) was mixed with 70% sulfuric acid (100 mL) and stirred at reflux for 3 hours. The acetamide 3b was separated from the reaction mixture by steam distillation to give the hydrolysis product of 2-methyl-6-nitroaniline (4b). After the distiller was cooled, the isolated bright orange needle-like crystals 4b were collected on a Brinell funnel and dried in a vacuum desiccator. If acetamide 3a was hydrolyzed, the warm reaction mixture was diluted with 350 mL of water and alkalized with 10% aqueous sodium hydroxide. After cooling to room temperature, 4-methyl-2-nitroaniline (4a) precipitated as a brown powder, which was separated by vacuum filtration, washed with three parts of 200 mL of water, and dried in a vacuum desiccator. The yields of compounds 4a and 4b were 53.6% (40.73 g) and 52.3% (39.78 g), respectively.

References

[1] Bulletin des Societes Chimiques Belges, 1969, vol. 78, p. 571 - 582
[2] Chemistry Letters, 1989, p. 1849 - 1852
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 13, p. 6047 - 6060
[4] Polyhedron, 2016, vol. 105, p. 137 - 149

2-Methyl-6-nitroaniline Preparation Products And Raw materials

Raw materials

2-METHYLACETANILIDE

Preparation Products

2,1,3-BENZOTHIADIAZOLE-4-CARBOXYLIC ACID 2,1,3-BENZOTHIADIAZOL-4-YLMETHANOL,97% 4-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE 7-Nitroindazole 1H-INDAZOL-7-AMINE 2,1,3-BENZOTHIADIAZOLE-4-CARBALDEHYDE
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View Lastest Price from 2-Methyl-6-nitroaniline manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Methyl-6-nitroaniline 570-24-1
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-17
Asia Chem I and E (Jiangsu) Co Ltd
Product
2-Methyl-6-nitroaniline 570-24-1
Price
US $83.72/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.0%HPLC
Supply Ability
10tons/month
Release date
2021-09-23
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Methyl-6-nitroaniline 570-24-1
Price
US $10.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23

570-24-1, 2-Methyl-6-nitroanilineRelated Search:

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  • Chemical Synthesis
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