1-Methyl-1H-pyrazole-5-carboxylic acid

Product Name: 1-Methyl-1H-pyrazole-5-carboxylic acid
CAS No.: 16034-46-1
Chemical Name: 1-Methyl-1H-pyrazole-5-carboxylic acid
Synonyms: SKL263;AKOS B000141;AKOS PAO-0505;CHEMBRDG-BB 4401287;ART-CHEM-BB B000141;TIMTEC-BB SBB000007;1-Methyl-1H-pyrazole-5-ca...;1-Methyl-pyrazole-5-carboxylicacid;2-Methylpyrazole-3-carboxylic acid;1-Methyl-5-pyrazolecarboxylic acid
CBNumber: CB8467029
Molecular Formula: C5H6N2O2
Formula Weight: 126.11
MOL File: 16034-46-1.mol

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1-Methyl-1H-pyrazole-5-carboxylic acid Property

Melting point:: 220-225 °C
Boiling point:: 306.9±15.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 3.03±0.25(Predicted)
color: White to Almost white
λmax: 259nm(MeOH)(lit.)
InChIKey: JREJQAWGQCMSIY-UHFFFAOYSA-N
CAS DataBase Reference: 16034-46-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
RIDADR: 2811
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 722138
Product name: 1-Methyl-1H-pyrazole-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $197
Updated: 2025/07/31

TCI Chemical

Product number: M2494
Product name: 1-Methylpyrazole-5-carboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: M2494
Product name: 1-Methylpyrazole-5-carboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $90
Updated: 2025/07/31

TRC

Product number: M320925
Product name: 1-Methyl-1H-pyrazole-5-carboxylic acid
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR5218
Product name: 1-Methyl-1H-pyrazole-5-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $53
Updated: 2021/12/16

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1-Methyl-1H-pyrazole-5-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to yellow solid

Uses

1-Methyl-5-pyrazolecarboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Definition

ChEBI: 1-methyl-pyrazole-5-carboxylic acid is a member of the class of pyrazoles that is N-methylpyrazole substituted by a carboxy group substituents at position 5. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It is functionally related to a N-methylpyrazole.

Synthesis

930-36-9

124-38-9

16034-46-1

1-Methyl-1H-pyrazole (2.0 g, 24.4 mmol) was dissolved in tetrahydrofuran (THF, 30 mL) at room temperature. The reaction mixture was cooled to -78 °C under nitrogen protection, followed by slow dropwise addition of n-butyllithium (n-BuLi, 10.72 mL, 26.8 mmol). The reaction temperature of -78 °C was maintained and the reaction mixture was stirred for 2 h. Subsequently, it was gradually warmed up to room temperature and stirring was continued for 1 h. The reaction temperature was maintained at -78 °C. Under the condition of maintaining the reaction temperature, dry carbon dioxide gas was passed into the reaction solution for about 5 minutes. The reaction mixture continued to be stirred at room temperature for 1 hour. Subsequently, water (30 mL) was added to the reaction mixture to quench the reaction and dilute the mixture. The reaction mixture was extracted with dichloromethane. After precipitation of a large amount of solid from the acidic aqueous phase, the separation was carried out by filtration. The resulting filter cake was dried to give a final 1.5 g of white solid product 1-methyl-1H-pyrazole-5-carboxylic acid in 48.8% yield.

References

[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 6, p. 650 - 654
[2] Patent: CN105384739, 2016, A. Location in patent: Paragraph 0345; 0346; 0347
[3] Patent: WO2009/71705, 2009, A1. Location in patent: Page/Page column 39
[4] Patent: WO2009/71706, 2009, A1. Location in patent: Page/Page column 48
[5] Patent: US2008/242661, 2008, A1. Location in patent: Page/Page column 25

1-Methyl-1H-pyrazole-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Diethyl ether 1-Methylpyrazole n-Butyllithium

Preparation Products

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View Lastest Price from 1-Methyl-1H-pyrazole-5-carboxylic acid manufacturers

Career Henan Chemical Co

Product: 1-Methyl-1H-pyrazole-5-carboxylic acid 16034-46-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-19

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SKL263

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16034-46-1

CARBOXYLIC ACID

Carboxylic Acids

Pyrazoles & Triazoles

Carboxy

Building Blocks

Pyrazole

Carboxylic Acids

Pyrazoles & Triazoles