4-CYANOBENZENESULFONYL CHLORIDE 97
- Product Name
- 4-CYANOBENZENESULFONYL CHLORIDE 97
- CAS No.
- 49584-26-1
- Chemical Name
- 4-CYANOBENZENESULFONYL CHLORIDE 97
- Synonyms
- 4-Cyanobenzenesulfonyl chloride;4-CYANOBENZENESULFON;C-Nitrile, S-chloride;p-Cyanobenzenesulphonylchloride;4-(Chlorosulfonyl)-benzonitrile;p-Cyanobenzenesulfonyl chloride;4-(Chlorosulphonyl)benzonitrile;4-Cyanobenzenesulphonyl chloride;paraCyanobenzene Sulfonyl Chloride;Benzenesulfonyl chloride, 4-cyano-
- CBNumber
- CB8498797
- Molecular Formula
- C7H4ClNO2S
- Formula Weight
- 201.63
- MOL File
- 49584-26-1.mol
4-CYANOBENZENESULFONYL CHLORIDE 97 Property
- Melting point:
- 107-111 °C (lit.)
- Boiling point:
- 90-95 °C(Press: 3-4 Torr)
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- color
- White to Light yellow
- Sensitive
- Moisture Sensitive
- BRN
- 777939
- CAS DataBase Reference
- 49584-26-1(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-43-29-20/21/22-14
- Safety Statements
- 26-36/37/39-45-30-22-8
- RIDADR
- UN 3261 8/PG 3
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 638331
- Product name
- 4-Cyanobenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $43.2
- Updated
- 2023/06/20
- Product number
- 638331
- Product name
- 4-Cyanobenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $78.9
- Updated
- 2023/06/20
- Product number
- C1813
- Product name
- 4-Cyanobenzenesulfonyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- C1813
- Product name
- 4-Cyanobenzenesulfonyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $99
- Updated
- 2025/07/31
- Product number
- C962358
- Product name
- 4-Cyanobenzenesulfonyl Chloride
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
4-CYANOBENZENESULFONYL CHLORIDE 97 Chemical Properties,Usage,Production
Chemical Properties
Light orange solid
Uses
4-Cyanobenzenesulfonyl chloride is a useful research chemical compound used in the preparation of phenyldiazenyl-sulfonamides as aromatase inhibitors.
Synthesis
150993-53-6
49584-26-1
N-Chlorosuccinimide (NCS, 1.778 g, 13.32 mmol) was slowly added to a suspension of 4-(benzylthio)benzonitrile (1 g, 4.44 mmol) dissolved in acetic acid (AcOH, 10 mL) and water (3.5 mL) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc), washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a hexane solution of 15%-20% ethyl acetate as eluent to give a white solid. The resulting solid was washed with hexane and dried under reduced pressure to give 4-cyanobenzenesulfonyl chloride (0.701 g, 3.48 mmol, 78% yield) as a white solid. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.91-7.97 (2H, m), 8.15-8.21 (2H, m).
References
[1] Patent: WO2018/30550, 2018, A1. Location in patent: Paragraph 0605
[2] Tetrahedron Letters, 2017, vol. 58, # 23, p. 2244 - 2247
4-CYANOBENZENESULFONYL CHLORIDE 97 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CYANOBENZENESULFONYL CHLORIDE 97 manufacturers
- Product
- 4-CYANOBENZENESULFONYL CHLORIDE 97 49584-26-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08