3-Cyanobenzene-1-sulfonyl chloride
- Product Name
- 3-Cyanobenzene-1-sulfonyl chloride
- CAS No.
- 56542-67-7
- Chemical Name
- 3-Cyanobenzene-1-sulfonyl chloride
- Synonyms
- 3-CYANOBENZENESULFONYL CHLORIDE;AKOS BB-9463;BUTTPARK 33\11-95;3-Cyanobenzene-1-;3-Cyanobenzene-1-sul;3-Cyanobenzenesulfonylchlorid;3-(Chlorosulfonyl)benzonitrile;3-cyanophenylsulfonyl chloride;M-Cyanobenzenesulfonyl chloride;3-(Chlorosulphonyl)benzonitrile
- CBNumber
- CB1126817
- Molecular Formula
- C7H4ClNO2S
- Formula Weight
- 201.63
- MOL File
- 56542-67-7.mol
3-Cyanobenzene-1-sulfonyl chloride Property
- Melting point:
- 49-53 °C (lit.)
- Boiling point:
- 148 °C
- Density
- 1.53±0.1 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- color
- White to Light yellow to Dark green
- Sensitive
- Moistute Sensitive
- BRN
- 2832925
- CAS DataBase Reference
- 56542-67-7(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-43-20/21/22
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3261 8/PG 3
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 638358
- Product name
- 3-Cyanobenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $310
- Updated
- 2022/05/15
- Product number
- C1812
- Product name
- 3-Cyanobenzenesulfonyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $153
- Updated
- 2025/07/31
- Product number
- C1812
- Product name
- 3-Cyanobenzenesulfonyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $610
- Updated
- 2025/07/31
- Product number
- C962280
- Product name
- 3-Cyanobenzenesulfonyl Chloride
- Packaging
- 10g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- 007157
- Product name
- 3-Cyanobenzenesulfonyl Chloride
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
3-Cyanobenzene-1-sulfonyl chloride Chemical Properties,Usage,Production
Uses
A benzenesulfonamide derivative as potential kinase inhibitors.
Synthesis
2237-30-1
56542-67-7
General procedure for the synthesis of 3-cyanobenzenesulfonyl chloride from 3-aminobenzonitrile: 3-aminobenzonitrile (2.5 g, 21 mmol) was dissolved in concentrated hydrochloric acid. The mixture of hydrochloric acid (20 mL) and water (20 mL) was cooled to 0 °C and a solution of sodium nitrite (1.5 g, 22 mmol) in water (5 mL) was added slowly and dropwise. The reaction mixture was stirred at 0 °C for 10 min to ensure complete formation of the diazonium salt. In another flask, copper (I) chloride (0.2 g) was added to a solution of acetic acid (25 mL) pre-saturated with sulfur dioxide and stirred at 0°C for 10 minutes. This solution was slowly added dropwise to the above diazonium salt solution, kept at 0°C and stirred for 1 hour. After completion of the reaction, the mixture was poured into ice water and the product was extracted with tert-butyl methyl ether. The organic layers were combined and washed sequentially with water and brine. The crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 5% ethyl acetate in petroleum ether solution) to give pure 3-cyanobenzenesulfonyl chloride (1.9 g, 45% yield) as an off-white solid.1H NMR (300 MHz, CDCl3) δ 8.35 (t, J=1.5 Hz, 1H), 8.31-8.27 (m, 1H), and 8.06-8.02 (m, 1H), 7.82 (t, J=7.9Hz, 1H).
References
[1] Collection of Czechoslovak Chemical Communications, 1999, vol. 64, # 11, p. 1833 - 1848
[2] Patent: EP2533783, 2015, B1. Location in patent: Paragraph 0335-0336
[3] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 5, p. 1182 - 1192
[4] Patent: US2002/128480, 2002, A1
[5] Patent: EP1258252, 2002, A1
3-Cyanobenzene-1-sulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Cyanobenzene-1-sulfonyl chloride manufacturers
- Product
- 3-Cyanobenzene-1-sulfonyl chloride 56542-67-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 3-Cyanobenzene-1-sulfonyl chloride 56542-67-7
- Price
- US $10.00/KG/Tin
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2019-06-28