ChemicalBook > CAS DataBase List > 3-Cyanobenzene-1-sulfonyl chloride

3-Cyanobenzene-1-sulfonyl chloride

Product Name: 3-Cyanobenzene-1-sulfonyl chloride
CAS No.: 56542-67-7
Chemical Name: 3-Cyanobenzene-1-sulfonyl chloride
Synonyms: 3-CYANOBENZENESULFONYL CHLORIDE;AKOS BB-9463;BUTTPARK 33\11-95;3-Cyanobenzene-1-;3-Cyanobenzene-1-sul;3-Cyanobenzenesulfonylchlorid;3-(Chlorosulfonyl)benzonitrile;3-cyanophenylsulfonyl chloride;M-Cyanobenzenesulfonyl chloride;3-(Chlorosulphonyl)benzonitrile
CBNumber: CB1126817
Molecular Formula: C7H4ClNO2S
Formula Weight: 201.63
MOL File: 56542-67-7.mol

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3-Cyanobenzene-1-sulfonyl chloride Property

Melting point:: 49-53 °C (lit.)
Boiling point:: 148 °C
Density: 1.53±0.1 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
color: White to Light yellow to Dark green
Sensitive: Moistute Sensitive
BRN: 2832925
CAS DataBase Reference: 56542-67-7(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34-43-20/21/22
Safety Statements: 26-36/37/39-45
RIDADR: UN 3261 8/PG 3
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 638358
Product name: 3-Cyanobenzenesulfonyl chloride
Purity: 97%
Packaging: 5g
Price: $310
Updated: 2022/05/15

TCI Chemical

Product number: C1812
Product name: 3-Cyanobenzenesulfonyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $153
Updated: 2025/07/31

TCI Chemical

Product number: C1812
Product name: 3-Cyanobenzenesulfonyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $610
Updated: 2025/07/31

TRC

Product number: C962280
Product name: 3-Cyanobenzenesulfonyl Chloride
Packaging: 10g
Price: $970
Updated: 2021/12/16

Usbiological

Product number: 007157
Product name: 3-Cyanobenzenesulfonyl Chloride
Packaging: 1g
Price: $403
Updated: 2021/12/16

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3-Cyanobenzene-1-sulfonyl chloride Chemical Properties,Usage,Production

Uses

A benzenesulfonamide derivative as potential kinase inhibitors.

Synthesis

2237-30-1

56542-67-7

General procedure for the synthesis of 3-cyanobenzenesulfonyl chloride from 3-aminobenzonitrile: 3-aminobenzonitrile (2.5 g, 21 mmol) was dissolved in concentrated hydrochloric acid. The mixture of hydrochloric acid (20 mL) and water (20 mL) was cooled to 0 °C and a solution of sodium nitrite (1.5 g, 22 mmol) in water (5 mL) was added slowly and dropwise. The reaction mixture was stirred at 0 °C for 10 min to ensure complete formation of the diazonium salt. In another flask, copper (I) chloride (0.2 g) was added to a solution of acetic acid (25 mL) pre-saturated with sulfur dioxide and stirred at 0°C for 10 minutes. This solution was slowly added dropwise to the above diazonium salt solution, kept at 0°C and stirred for 1 hour. After completion of the reaction, the mixture was poured into ice water and the product was extracted with tert-butyl methyl ether. The organic layers were combined and washed sequentially with water and brine. The crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 5% ethyl acetate in petroleum ether solution) to give pure 3-cyanobenzenesulfonyl chloride (1.9 g, 45% yield) as an off-white solid.1H NMR (300 MHz, CDCl3) δ 8.35 (t, J=1.5 Hz, 1H), 8.31-8.27 (m, 1H), and 8.06-8.02 (m, 1H), 7.82 (t, J=7.9Hz, 1H).

References

[1] Collection of Czechoslovak Chemical Communications, 1999, vol. 64, # 11, p. 1833 - 1848
[2] Patent: EP2533783, 2015, B1. Location in patent: Paragraph 0335-0336
[3] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 5, p. 1182 - 1192
[4] Patent: US2002/128480, 2002, A1
[5] Patent: EP1258252, 2002, A1

3-Cyanobenzene-1-sulfonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Cyanobenzene-1-sulfonyl chloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Cyanobenzene-1-sulfonyl chloride 56542-67-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 3-Cyanobenzene-1-sulfonyl chloride 56542-67-7
Price: US $10.00/KG/Tin
Min. Order: 1KG
Purity: 99%
Supply Ability: 100
Release date: 2019-06-28

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56542-67-7

C7H4NO2ClS

C7H4NSCLO2

SULFONYL CHLORIDE

Building Blocks

Organic Building Blocks

Sulfur Compounds

Sulfonyl Halides

Aromatics

Inhibitors

Sulfur & Selenium Compounds

Phenyls & Phenyl-Het

Sulphonyl Chlorides

Benzenesulfonyl chloride

Phenyls & Phenyl-Het

Sulphonyl Chlorides

Organic Building Blocks

Sulfonyl Halides

Sulfur Compounds