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LY3143921

Product Name
LY3143921
CAS No.
1627696-53-0
Chemical Name
LY3143921
Synonyms
LY3143921;LY3143921 hydrate;LY3143921 hydrate ，S9650;LY-3143921 hydrate,LY3143921 hydrate
CBNumber
CB85867383
Molecular Formula
C16H14FN5O2
Formula Weight
327.32
MOL File
1627696-53-0.mol
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LY3143921 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 65 mg/mL (198.59 mM);Ethanol: 32 mg/mL (97.77 mM)
form 
Solid
color 
White to off-white
Water Solubility 
Water: Insoluble
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Hazard and Precautionary Statements (GHS)

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LY3143921 Chemical Properties,Usage,Production

Uses

LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer[1][2].

Biological Activity

LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.

in vivo

LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].

Animal Model:Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells[1]
Dosage:10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration:Oral gavage; twice a day for 2 weeks
Result:Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.

IC 50

Cdc7: 3.3 nM (IC50); pMCM2: 290 nM (IC50)

References

[1] Peter F. Gallagher, et al. Journal of Clinical Oncology. Volume 37, Issue 15_suppl.

LY3143921 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY3143921 Suppliers

China 16 United States 3 Global 19
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58

1627696-53-0, LY3143921Related Search:

LY 294002 Hydrochloride 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY-404039 LY 2606368 LY 379268 LY-2940094 LY2109761

  • LY3143921
  • LY3143921 hydrate
  • LY-3143921 hydrate,LY3143921 hydrate
  • LY3143921 hydrate ，S9650
  • 1627696-53-0