ChemicalBook > CAS DataBase List > Triphenylmethyl Chloride

Triphenylmethyl Chloride

Product Name
Triphenylmethyl Chloride
CAS No.
76-83-5
Chemical Name
Triphenylmethyl Chloride
Synonyms
TRT-CL;TRITYL CHLORIDE;(ChloroMethanetriyl)tribenzene;CHLOROTRIPHENYLMETHANE;TRIPHENYLCHLOROMETHANE;[Chloro(diphenyl)methyl]benzene;TRITY CHLORIDE;TRIPHENYLCHLORMETHANE;chlorotriphenyl-methan;NSC 435
CBNumber
CB8669405
Molecular Formula
C19H15Cl
Formula Weight
278.78
MOL File
76-83-5.mol
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Triphenylmethyl Chloride Property

Melting point:
109-112 °C(lit.)
Boiling point:
230-235 °C20 mm Hg(lit.)
Density 
1.1088 (rough estimate)
refractive index 
1.6281 (estimate)
Flash point:
230-235°C/20mm
storage temp. 
Store below +30°C.
solubility 
chloroform: 0.1 g/mL, clear
form 
Powder or Crystals
color 
White to off-white or light yellow-beige
Water Solubility 
Insoluble in water. Soluble in chloroform, hexane, benzene, ether, acetone and tetrahydrofuran.
Sensitive 
Lachrymatory
BRN 
397363
CAS DataBase Reference
76-83-5(CAS DataBase Reference)
NIST Chemistry Reference
Triphenylmethyl chloride(76-83-5)
EPA Substance Registry System
Chlorotriphenylmethane (76-83-5)
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Safety

Hazard Codes 
C,N
Risk Statements 
34-50/53-14-36/37
Safety Statements 
26-36/37/39-45-61-27
RIDADR 
UN 3261 8/PG 3
WGK Germany 
3
RTECS 
PA6450000
F 
10-19-21
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29036990
Hazardous Substances Data
76-83-5(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
93000
Product name
Trityl chloride
Purity
purum, ≥97.0% (HPLC), ≥97.0% (AT)
Packaging
100g
Price
$50.7
Updated
2024/03/01
Sigma-Aldrich
Product number
93000
Product name
Trityl chloride
Purity
purum, ≥97.0% (HPLC), ≥97.0% (AT)
Packaging
5kg
Price
$1520
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08348
Product name
Chlorotriphenylmethane
Purity
for synthesis
Packaging
250g
Price
$67.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08348
Product name
Chlorotriphenylmethane
Purity
for synthesis
Packaging
1kg
Price
$264
Updated
2024/03/01
TCI Chemical
Product number
C0308
Product name
Trityl Chloride
Purity
>98.0%(T)
Packaging
25g
Price
$23
Updated
2024/03/01
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Triphenylmethyl Chloride Chemical Properties,Usage,Production

Chemical Properties

Triphenylmethyl chloride or trityl chloride (TrCl) is a white to yellow solid. Insoluble in water, easily soluble in benzene, carbon disulfide, petroleum ether, slightly soluble in alcohol and ether, and becomes trityl alcohol after absorbing water. It is an alkyl halide, sometimes used to introduce the trityl protecting group.

Uses

Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-bindin g inhibitor of Eg5 that prevents mitotic progression.

Application

Triphenylmethyl Chloride acts as a protecting reagent for amines, alcohols, and thiols. It can be used as a catalyst:
Efficient method of tritylation of sensitive compounds and their subsequent detritylation.
In Ritter type synthesis of 1-amidoalkyl-2-naphtols through a one-pot three-component reaction of naphthol, aryl aldehydes and acetonitrile.
In the synthesis of 1,2,4,5-tetrasubstituted imidazoles via a one-pot multi-component reaction of benzil with aldehydes, primary amines, and ammonium acetate.
In the preparation of amido alkyl phenols via one-pot, multi-component reaction of phenols, aromatic aldehydes, and amides under solvent-free conditions.
In one-pot, multi-component synthesis of substituted piperidines using aromatic aldehydes, amines, and β-ketoesters.

Preparation

Triphenylmethyl Chloride may be prepared by the reaction of triphenylmethanol with acetyl chloride, or by the Friedel–Crafts alkylation of benzene with carbon tetrachloride to give the trityl chloride-aluminium chloride adduct, which is then hydrolyzed.

Purification Methods

Crystallise trityl chloride from iso-octane. Also crystallise it from 5 parts of pet ether (b 90-100o) and 1 part of acetyl chloride using 1.8g of solvent per g of chloride. Dry it in a desiccator over soda lime and paraffin wax. [Bachman Org Synth Coll Vol III 841 1955, Thomas & Rochow J Am Chem Soc 79 1843 1957, Moisel et al. J Am Chem Soc 108 4706 1986, Beilstein 5 H 750, 5 I 346, 5 II 615, 5 III 2315, 5 IV 2497.] It is moisture sensitive and LACHRYMATORY,

Triphenylmethyl Chloride Preparation Products And Raw materials

Raw materials

TRIPHENYL METHANE CHLORID

Preparation Products

1-Trityl-1H-imidazole-4-carboxylic acid N-Boc-S-Trityl-L-cysteine 1H-Imidazole-4-carbaldehyde 2-(AMINOMETHYL)CYCLOPROPANECARBOXYLIC ACID
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Triphenylmethyl Chloride Suppliers

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View Lastest Price from Triphenylmethyl Chloride manufacturers

Jinan Finer Chemical Co., Ltd
Product
Triphenylmethyl chloride 76-83-5
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
200mt
Release date
2021-12-13
WUHAN FORTUNA CHEMICAL CO., LTD
Product
TriphenylMethyl chloride 76-83-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
10 tons
Release date
2021-07-22
Hebei Chuanghai Biotechnology Co,.LTD
Product
Triphenylmethyl Chloride 76-83-5
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-14

76-83-5, Triphenylmethyl ChlorideRelated Search:

Polyvinyl chloride Ammonium chloride Choline chloride Chloromethane Triphenylmethane Sodium chloride Potassium chloride Diethylstilbestrol Chlorodiphenylmethane Acetyl chloride Calcium chloride Benzyl chloride Benzyltriphenylphosphonium chloride Triphenylsilyl chloride Triphenylsilane TRIS(DIMETHYLSILOXY)ETHOXYSILANE 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester OlMesartan MedoxoMil Methyl Ether IMpurity

  • [Chloro(diphenyl)methyl]benzene
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  • CHLOROTRIPHENYLMETHANE
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  • CHLOROTRIPHENYLMETHANE FOR SYNTHESIS
  • Chlorotriphenylmethane, 1,1',1''-(Chloromethanetriyl)tribenzene
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  • Trityl chloride, polymer-bound 100-200 mesh, extent of labeling: ~1.1 mmol/g Cl loading
  • (ChloroMethanetriyl)tribenzene
  • Trityl Chloride 〔Chlorotriphenylmethane〕
  • Triphenylmethyl chloride≥ 99% (HPLC)
  • Trt-Cl Chlorotriphenylmethane Triphenylchloromethane Triphenylmethyl chloride
  • Chlortriphenylmethan
  • PH3C-CL
  • D-(-)-p-Hydroxyphenylglycine Dane Salt(M.K.)
  • syn. Nae Chlorotriphenylmethane
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  • Triphenylmethyl chloride (Trityl chloride)
  • TryTylchloride
  • Chlorotriphenylmethane,98%
  • Triphenyl chloeomethane
  • Triphenylchloromethan
  • TRITYL CHLORIDE 98%
  • TRT-CL(TRITYLCHLORIDE)
  • Triphenylmethyl chlorideChlorotriphenylmethane
  • Chlorotriphenylmethane, Triphenylchloromethane, Triphenylmethyl chloride
  • [Chloro-di(phenyl)methyl]benzen
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  • Chloromethylidynetrisbenzene
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  • Co-Formula CFS-835
  • CFS-835
  • TritylChloride&gt
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