Triphenylmethyl Chloride

Product Name: Triphenylmethyl Chloride
CAS No.: 76-83-5
Chemical Name: Triphenylmethyl Chloride
Synonyms: TRT-CL;TRITYL CHLORIDE;(ChloroMethanetriyl)tribenzene;CHLOROTRIPHENYLMETHANE;TRIPHENYLCHLOROMETHANE;[Chloro(diphenyl)methyl]benzene;TRITY CHLORIDE;TRIPHENYLCHLORMETHANE;chlorotriphenyl-methan;NSC 435
CBNumber: CB8669405
Molecular Formula: C19H15Cl
Formula Weight: 278.78
MOL File: 76-83-5.mol

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Triphenylmethyl Chloride Property

Melting point:: 109-112 °C(lit.)
Boiling point:: 230-235 °C20 mm Hg(lit.)
Density: 1.1088 (rough estimate)
refractive index: 1.6281 (estimate)
Flash point:: 230-235°C/20mm
storage temp.: Store below +30°C.
solubility: chloroform: 0.1 g/mL, clear
form: Powder or Crystals
color: White to off-white or light yellow-beige
Water Solubility: Insoluble in water. Soluble in chloroform, hexane, benzene, ether, acetone and tetrahydrofuran.
Sensitive: Lachrymatory
BRN: 397363
CAS DataBase Reference: 76-83-5(CAS DataBase Reference)
NIST Chemistry Reference: Triphenylmethyl chloride(76-83-5)
EPA Substance Registry System: Chlorotriphenylmethane (76-83-5)

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Safety

Hazard Codes: C,N
Risk Statements: 34-50/53-14-36/37
Safety Statements: 26-36/37/39-45-61-27
RIDADR: UN 3261 8/PG 3
WGK Germany: 3
RTECS: PA6450000
F: 10-19-21
Hazard Note: Irritant
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29036990
Hazardous Substances Data: 76-83-5(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: > 5000 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 93000
Product name: Trityl chloride
Purity: purum, ≥97.0% (HPLC), ≥97.0% (AT)
Packaging: 100g
Price: $50.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 93000
Product name: Trityl chloride
Purity: purum, ≥97.0% (HPLC), ≥97.0% (AT)
Packaging: 5kg
Price: $1520
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08348
Product name: Chlorotriphenylmethane
Purity: for synthesis
Packaging: 250g
Price: $67.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08348
Product name: Chlorotriphenylmethane
Purity: for synthesis
Packaging: 1kg
Price: $264
Updated: 2024/03/01

TCI Chemical

Product number: C0308
Product name: Trityl Chloride
Purity: >98.0%(T)
Packaging: 25g
Price: $23
Updated: 2024/03/01

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Triphenylmethyl Chloride Chemical Properties,Usage,Production

Chemical Properties

Triphenylmethyl chloride or trityl chloride (TrCl) is a white to yellow solid. Insoluble in water, easily soluble in benzene, carbon disulfide, petroleum ether, slightly soluble in alcohol and ether, and becomes trityl alcohol after absorbing water. It is an alkyl halide, sometimes used to introduce the trityl protecting group.

Uses

Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-bindin g inhibitor of Eg5 that prevents mitotic progression.

Application

Triphenylmethyl Chloride acts as a protecting reagent for amines, alcohols, and thiols. It can be used as a catalyst:
Efficient method of tritylation of sensitive compounds and their subsequent detritylation.
In Ritter type synthesis of 1-amidoalkyl-2-naphtols through a one-pot three-component reaction of naphthol, aryl aldehydes and acetonitrile.
In the synthesis of 1,2,4,5-tetrasubstituted imidazoles via a one-pot multi-component reaction of benzil with aldehydes, primary amines, and ammonium acetate.
In the preparation of amido alkyl phenols via one-pot, multi-component reaction of phenols, aromatic aldehydes, and amides under solvent-free conditions.
In one-pot, multi-component synthesis of substituted piperidines using aromatic aldehydes, amines, and β-ketoesters.

Preparation

Triphenylmethyl Chloride may be prepared by the reaction of triphenylmethanol with acetyl chloride, or by the Friedel–Crafts alkylation of benzene with carbon tetrachloride to give the trityl chloride-aluminium chloride adduct, which is then hydrolyzed.

Purification Methods

Crystallise trityl chloride from iso-octane. Also crystallise it from 5 parts of pet ether (b 90-100o) and 1 part of acetyl chloride using 1.8g of solvent per g of chloride. Dry it in a desiccator over soda lime and paraffin wax. [Bachman Org Synth Coll Vol III 841 1955, Thomas & Rochow J Am Chem Soc 79 1843 1957, Moisel et al. J Am Chem Soc 108 4706 1986, Beilstein 5 H 750, 5 I 346, 5 II 615, 5 III 2315, 5 IV 2497.] It is moisture sensitive and LACHRYMATORY,

Triphenylmethyl Chloride Preparation Products And Raw materials

Raw materials

TRIPHENYL METHANE CHLORID

Preparation Products

1-Trityl-1H-imidazole-4-carboxylic acid N-Boc-S-Trityl-L-cysteine 1H-Imidazole-4-carbaldehyde 2-(AMINOMETHYL)CYCLOPROPANECARBOXYLIC ACID

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Triphenylmethyl Chloride Suppliers

Americas 1 Austria 1 Belgium 1 Canada 5 China 629 China Hong Kong 1 Europe 7 France 1 Germany 13 India 69 Italy 1 Japan 13 Poland 1 Slovakia 1 South Korea 2 Switzerland 9 United Kingdom 13 United States 60 Global 828

TOKYO CHEMICAL INDUSTRY CO., LTD.

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Fine Corporation

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TCI Chemical Trading Co., Ltd.

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K. Sakai & Co., Ltd.

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TCI Japan

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Japanchem Incorporated

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Watanabe Chemical Industries, Ltd.

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Kanto Chemical Co., Inc.

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Wako Pure Chemical Industries, Ltd.

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Nacalai Tesque, Inc.

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Kokusan Chemical Co., Ltd.

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Junsei Chemical Co., Ltd.

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View Lastest Price from Triphenylmethyl Chloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: TriphenylMethyl chloride 76-83-5
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 10 tons
Release date: 2021-07-22

Jinan Finer Chemical Co., Ltd

Product: Triphenylmethyl chloride 76-83-5
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 200mt
Release date: 2021-12-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: Triphenylmethyl Chloride 76-83-5
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-14

76-83-5, Triphenylmethyl ChlorideRelated Search:

Polyvinyl chloride Ammonium chloride Choline chloride Chloromethane Triphenylmethane Sodium chloride Potassium chloride Diethylstilbestrol Chlorodiphenylmethane Acetyl chloride Calcium chloride Benzyl chloride Benzyltriphenylphosphonium chloride Triphenylsilyl chloride Triphenylsilane TRIS(DIMETHYLSILOXY)ETHOXYSILANE 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester OlMesartan MedoxoMil Methyl Ether IMpurity

[Chloro(diphenyl)methyl]benzene

1,1’,1’’-(chloromethylidyne)tris-benzen

1,1’,1’’(-Chloromethylidyne)trisben-zene

chlorotriphenyl-methan

Methane, chlorotriphenyl-

CHLOROTRIPHENYLMETHANE

BENZENE, 1,1',1''-(CHLOROMETHYLIDYNE)TRIS-

TRT-CL

TRITY CHLORIDE

TRITYL CHLORIDE

TRIPHENYLMETHYL CHLORIDE

TRIPHENYLCHLORMETHANE

TRIPHENYLCHLOROMETHANE

Triphenylmethyl chloride,98%

Triphenylmethyl chloride,99%

alpha-chlorotriphenylmethane

Triphenylchloromethane pure

Chlorotrisphenylmethane

TriphenylMethyl chloride, 98% 100GR

TriphenylMethyl chloride, 98% 500GR

NSC 435

CHLOROTRIPHENYLMETHANE FOR SYNTHESIS

Chlorotriphenylmethane, 1,1',1''-(Chloromethanetriyl)tribenzene

Trityl chloride puruM, >=97.0% (HPLC), >=97.0% (AT)

Trityl chloride, polymer-bound 100-200 mesh, extent of labeling: ~1.1 mmol/g Cl loading

(ChloroMethanetriyl)tribenzene

Trityl Chloride 〔Chlorotriphenylmethane〕

Triphenylmethyl chloride≥ 99% (HPLC)

Trt-Cl Chlorotriphenylmethane Triphenylchloromethane Triphenylmethyl chloride

Chlortriphenylmethan

PH3C-CL

D-(-)-p-Hydroxyphenylglycine Dane Salt(M.K.)

syn. Nae Chlorotriphenylmethane

Trityl chloride (Triphenylchloromethane)

Triphenylmethyl chloride (Trityl chloride)

TryTylchloride

Chlorotriphenylmethane,98%

Triphenyl chloeomethane

Triphenylchloromethan

TRITYL CHLORIDE 98%

TRT-CL(TRITYLCHLORIDE)

Triphenylmethyl chlorideChlorotriphenylmethane

Chlorotriphenylmethane, Triphenylchloromethane, Triphenylmethyl chloride

[Chloro-di(phenyl)methyl]benzen

Trityl chloride ,99%

Chloromethylidynetrisbenzene

Tritylchloride-Assay

Co-Formula CFS-835

CFS-835

TritylChloride&gt

Trityl chloride, 99%, for synthesis

Triphenylmethyl chloride,97%

TriphenylMethyl chloride USP/EP/BP

Boscalid 188425-85-6

Trityl Chloride [TTC

Triphenylmet

Ttityl Chloride

TRITYL CHLORIDE(TTCL)