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2'-Deoxy-2'-fluorocytidine

Product Name
2'-Deoxy-2'-fluorocytidine
CAS No.
10212-20-1
Chemical Name
2'-Deoxy-2'-fluorocytidine
Synonyms
2'-FC;2'-FdC;RO-8013;2'-F-dC;2'-FANA-C;NSC 529432;2’-F-2’-dC;2'-FLUORO-D-CYTIDINE;2'-Fluoro-d-Cytidine;2'-F-2'-deoxyCytidine
CBNumber
CB8670324
Molecular Formula
C9H12FN3O4
Formula Weight
245.21
MOL File
10212-20-1.mol
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2'-Deoxy-2'-fluorocytidine Property

Melting point:
167 °C
Boiling point:
500.1±60.0 °C(Predicted)
Density 
1.82±0.1 g/cm3(Predicted)
refractive index 
80 ° (C=1, MeOH)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Soluble in DMSO, Methanol.
pka
12.84±0.70(Predicted)
form 
Powder
color 
White to Off-white
Water Solubility 
Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
InChI
InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
InChIKey
NVZFZMCNALTPBY-XVFCMESISA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference
10212-20-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3614
Product name
2'-Deoxy-2'-fluorocytidine Hydrate
Purity
>98.0%(T)
Packaging
1g
Price
$68
Updated
2024/03/01
Alfa Aesar
Product number
J65632
Product name
2'-Fluoro-2'-deoxycytidine, 99%
Packaging
1g
Price
$52.65
Updated
2024/03/01
TRC
Product number
D232945
Product name
2’-Deoxy-2’-fluoroCytidine
Packaging
2g
Price
$145
Updated
2021/12/16
TRC
Product number
D232945
Product name
2’-Deoxy-2’-fluoroCytidine
Packaging
10g
Price
$525
Updated
2021/12/16
AK Scientific
Product number
AMTA037
Product name
2'-Fluoro-2'-deoxycytidine
Packaging
1g
Price
$25
Updated
2021/12/16
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2'-Deoxy-2'-fluorocytidine Chemical Properties,Usage,Production

Description

2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.

Chemical Properties

White Solid

Uses

2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.

in vitro

2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.

References

[1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.

2'-Deoxy-2'-fluorocytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Deoxy-2'-fluorocytidine Suppliers

Americas 1 Canada 2 China 242 Europe 3 Germany 3 India 7 Japan 1 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 11 United States 41 Global 314
CHEMICAL LAND21
Tel
--
Fax
--
Email
sales21@chemicalland21.com
Country
South Korea
ProdList
6303
Advantage
74
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View Lastest Price from 2'-Deoxy-2'-fluorocytidine manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
2'-Deoxy-2'-fluorocytidine 10212-20-1
Price
US $0.00/g
Min. Order
100g
Purity
≥98%
Supply Ability
20t
Release date
2023-05-11
Zhejiang Hengkang Pharmaceutical Co., Ltd.
Product
2'-FLUORO-D-CYTIDINE 10212-20-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg per month
Release date
2022-12-27
SHANGHAI NOVRIBO BIOTECH
Product
2'-F-2'-deoxyCytidine；2‘-F-dC 10212-20-1
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21

10212-20-1, 2'-Deoxy-2'-fluorocytidineRelated Search:

Cytidine 4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 5'-Deoxy-5-fluorocytidine Dmt-2'-f-dc(ac) amidite 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate Gemcitabine hydrochloride 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2''-DEOXY-2''-FLUORO-5-IODOCYTIDINE 2'-FLUORO-5'-O-DIMETHOXYTRITYL-N4-ACETYL-D-CYTIDINE 2'-DEOXY-3',5'-DI-O-BENZOYL-2',2'-DIFLUOROCYTIDINE-13C,15N2 DTBS-GEMCITABINE gemcitabine 2'-DEOXY-2'-FLUOROCYTIDINE, [3H]- 2'-FLUORO-2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT GEMCITABINE, [5-3H]- N4-Benzyl-2'-deoxy-2'-fluoro-5'-O-tritylcytidine-3'-O-cyanoethyldiisopropropylphosphoramidite

  • 4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • 4-AMINO-1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDIN-2-ONE
  • 2'-FLUORO-D-CYTIDINE
  • 2'-DEOXY-2'-FLUOROCYTIDINE
  • 2'-FC
  • 2'-FLUORO-2'-DEOXYCYTIDINE
  • 2'-FdC
  • 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine
  • 1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine
  • RO-8013
  • 2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'- DEOXYCYTIDINE, 2'-FC)
  • 2'-Deoxy-2'-fluoro-D-cytidine
  • 2''-DEOXY-2''-FLUOROCYTIDINE,99+%
  • 2'-Deoxy-2'-fluorocytidine Hydrate
  • 2'-Deoxy-2'-fluorocytidine ,98%
  • 2'-Fluoro-2'-deoxy-β-D-ribofuranosylcytosine
  • FN-009 2'-Fluoro-2'-deoxy-cytidine
  • Cytidine, 2'-deoxy-2'-fluoro-
  • 2'-FANA-C
  • NSC 529432
  • 2'-Deoxy-2'-fluorocytidine&nbsp
  • 2'-Deoxy-2'-fluorocytidine≥ 99% (HPLC)
  • Fludarabine Phosphate Impurity 18
  • 2'-Fluoro-2'-deoxycytidine, >98.0%(T)
  • 2'-Deoxy-2'-fluorocytidineHydrate&gt
  • 2’-F-2’-dC
  • 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one USP/EP/BP
  • 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl...
  • 2'-F-2'-deoxyCytidine
  • Crimean-Congo hemorrhagic fever,2' Deoxy 2' fluorocytidine,Inhibitor,nucleoside analog,inhibit,Influenza Virus,2'Deoxy2'fluorocytidine,Antiviral,CCHFV
  • 2'-Fluoro-2'-Deoxycytidine (FdC)
  • 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
  • 2'-Fluoro-2'-Deoxycytidine
  • 2'-Deoxy-2"-fuorocytidine
  • 2'-F-2'-deoxycytidine
  • 2'-Deoxy-2'-fluorocytidine
  • 2'-F-dC
  • Cytidine, 2'-deoxy-2'-fluoro-
  • 2'-Fluoro-d-Cytidine
  • 10212-20-1
  • 110212-20-1
  • C9H12FN3O4xH2O
  • C9H12N3O4F
  • C9H12FN3O4
  • Biochemistry
  • Nucleosides and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • 10212-20-1
  • Nucleosides
  • Modified（deoxy）nucleoside
  • Nucleosides-2'-F Nucleosides