ChemicalBook > CAS DataBase List > Ethyl N-piperazinecarboxylate

Ethyl N-piperazinecarboxylate

Product Name
Ethyl N-piperazinecarboxylate
CAS No.
120-43-4
Chemical Name
Ethyl N-piperazinecarboxylate
Synonyms
ETHYL PIPERAZINE-1-CARBOXYLATE;1-CARBETHOXYPIPERAZINE;AKOS BC-0597;RARECHEM AH CK 0098;TIMTEC-BB SBB003993;LABOTEST-BB LT00138086;N-CARBETHOXYPIPERAZINE;ethylcarbonylpiperazine;1-CARBOETHOXYPIPERAZINE;Ethylcarbonyl piperazine
CBNumber
CB8698856
Molecular Formula
C7H14N2O2
Formula Weight
158.2
MOL File
120-43-4.mol
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Ethyl N-piperazinecarboxylate Property

Melting point:
120 °C
Boiling point:
273 °C (lit.)
Density 
1.08 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.477(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Oily Liquid
pka
8.50±0.10(Predicted)
color 
Clear light yellow
Water Solubility 
soluble
BRN 
125780
CAS DataBase Reference
120-43-4(CAS DataBase Reference)
NIST Chemistry Reference
1-Piperazinecarboxylic acid, ethyl ester(120-43-4)
EPA Substance Registry System
1-Piperazinecarboxylic acid, ethyl ester (120-43-4)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
23-24/25-37/39-26-36
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
RTECS 
TL1378000
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E45600
Product name
Ethyl 1-piperazinecarboxylate
Purity
99%
Packaging
25g
Price
$62.6
Updated
2025/07/31
Sigma-Aldrich
Product number
E45600
Product name
Ethyl 1-piperazinecarboxylate
Purity
99%
Packaging
100g
Price
$135
Updated
2023/01/07
TCI Chemical
Product number
P1349
Product name
Ethyl 1-Piperazinecarboxylate
Purity
>96.0%(GC)
Packaging
25g
Price
$28
Updated
2025/07/31
TCI Chemical
Product number
P1349
Product name
Ethyl 1-Piperazinecarboxylate
Purity
>96.0%(GC)
Packaging
500g
Price
$282
Updated
2021/12/16
TRC
Product number
E922500
Product name
Ethyl 1-Piperazinecarboxylate
Packaging
5g
Price
$70
Updated
2021/12/16
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Ethyl N-piperazinecarboxylate Chemical Properties,Usage,Production

Chemical Properties

clear light yellow oily liquid

Uses

Intermediate.

Synthesis

110-85-0

541-41-3

120-43-4

Piperazine (2 g, 23.2 mmol) and deionized water (10 mL) were added to a reaction flask and stirred at 25 °C until completely dissolved, then cooled to 0 °C. A methanol solution (20 mL) of ethyl chloroformate (1.26 g, 11.6 mmol) was slowly added dropwise with stirring. After the dropwise addition was completed, the reaction system was warmed to 25 °C and stirring was continued for 4 hours. Upon completion of the reaction, saturated aqueous sodium chloride solution (30 mL) and dichloromethane (200 mL) were added to the reaction solution for extraction and separation. The organic layer was collected and dried with anhydrous sodium sulfate. The organic solvent was removed by distillation under reduced pressure, and the resulting crude product was purified by column chromatography (eluent: dichloromethane/methanol, 40:1, v/v/v/v) to give ethyl N-piperazinecarboxylate (0.62 g, 33.7% yield) as a white solid.

References

[1] Patent: CN103664899, 2017, B. Location in patent: Paragraph 0465-0469
[2] Patent: CN103664925, 2018, B. Location in patent: Paragraph 0458; 0461; 0462
[3] Journal of the Chemical Society, 1929, p. 50
[4] Journal of Organic Chemistry, 1948, vol. 13, p. 134,138
[5] Chemische Berichte, 1933, vol. 66, p. 113,116

Ethyl N-piperazinecarboxylate Preparation Products And Raw materials

Raw materials

Ethanol Piperazine Ethyl chloroformate Isopropyl acetate Hydrochloric acid Sodium hydroxide Magnesium Carbon

Preparation Products

7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER 1-Piperonylpiperazine Amoxapine
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View Lastest Price from Ethyl N-piperazinecarboxylate manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Ethyl N-piperazinecarboxylate 120-43-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08
Hebei Yanxi Chemical Co., Ltd.
Product
Ethyl N-piperazinecarboxylate 120-43-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08
Dideu Industries Group Limited
Product
Ethyl N-piperazinecarboxylate 120-43-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-23

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