ChemicalBook > CAS DataBase List > Pyrazole-3-boronic acid

Pyrazole-3-boronic acid

Product Name
Pyrazole-3-boronic acid
CAS No.
376584-63-3
Chemical Name
Pyrazole-3-boronic acid
Synonyms
1H-PYRAZOLE-3-BORONIC ACID;1H-Pyrazole-5-boronic acid;e-5-boronic acid;CHEMBRDG-BB 4201615;3-Pyrazoleboronicacid;Pyrazole-3-boronicaci;Pyrazole-5-boronic acid;Pyrazole-2-boronic acid;Pyrazole-3-boronic acid;Pyrazol-3-ylboronic acid
CBNumber
CB8704890
Molecular Formula
C3H5BN2O2
Formula Weight
111.89
MOL File
376584-63-3.mol
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Pyrazole-3-boronic acid Property

Melting point:
85-88°C
Boiling point:
430.4±37.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
solid
pka
8.58±0.53(Predicted)
color 
Off-white
Water Solubility 
Soluble in water.
InChI
InChI=1S/C3H5BN2O2/c7-4(8)3-1-2-5-6-3/h1-2,7-8H,(H,5,6)
InChIKey
NEUWPDLMDVINSN-UHFFFAOYSA-N
SMILES
N1C=CC(B(O)O)=N1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B529883
Product name
1h-Pyrazole-3-boronicAcid
Packaging
100mg
Price
$45
Updated
2021/12/16
Usbiological
Product number
287935
Product name
1H-Pyrazol-3-yl boronic acid
Packaging
500mg
Price
$360
Updated
2021/12/16
AK Scientific
Product number
W5854
Product name
(1H-Pyrazol-3-yl)boronicacid
Packaging
5g
Price
$201
Updated
2021/12/16
AK Scientific
Product number
J92698
Product name
(1H-Pyrazol-3-yl)boronicacid
Packaging
10g
Price
$250
Updated
2021/12/16
Apolloscientific
Product number
OR8413
Product name
1H-Pyrazole-5-boronicacid
Packaging
10g
Price
$279
Updated
2021/12/16
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Pyrazole-3-boronic acid Chemical Properties,Usage,Production

Uses

Significantly used as synthetic intermediates. They are widely used in the production of optics.

Synthesis

449758-17-2

376584-63-3

General procedure for the synthesis of 1H-pyrazole-3-boronic acid from 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole: To a solution of 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole (7.6 g, 52 mmol) in tetrahydrofuran (THF, 50 mL) was added slowly at -78 °C n-butyllithium (n-BuLi, 33 mL, 2.5 M hexane solution, 82.5 mmol), followed by the addition of triisopropylborane (12.7 mL, 55 mmol) dropwise, keeping the reaction temperature at -70 °C. The reaction mixture was stirred at -70 °C for 1 hour and then slowly warmed to room temperature over 4 hours. After completion of the reaction, the reaction was quenched with 2M hydrochloric acid (HCl) and the solvent was removed under vacuum. The pH of the reaction mixture was adjusted to 6 with 1M sodium hydroxide (NaOH) solution, at which time a precipitate was formed. The precipitate was collected by filtration, washed sequentially with toluene and petroleum ether, and finally ground with ethyl acetate to afford 1H-pyrazole-3-boronic acid as a white solid (2.7 g, 48% yield), and the product could be used in subsequent reactions without further purification.

References

[1] Patent: WO2007/138072, 2007, A2. Location in patent: Page/Page column 55
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 12, p. 2995 - 3008

Pyrazole-3-boronic acid Preparation Products And Raw materials

Raw materials

Sodium hydride Trifluoroacetic acid 3,4-Dihydro-2H-pyran Pyrazole Tetrahydrofuran Hydrochloric acid Triisopropyl borate n-Butyllithium

Preparation Products

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View Lastest Price from Pyrazole-3-boronic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1H-Pyrazol-3-ylboronic acid 376584-63-3
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-07-05
Career Henan Chemical Co
Product
Pyrazole-3-boronic acid 376584-63-3
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-22

376584-63-3, Pyrazole-3-boronic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Pyraclostrobin Pyrazole Folic acid Glycine Zolpidem tartrate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE Dimethyl 1H-pyrazole-3,5-dicarboxylate 5-Pyrazolecarboxylic acid 4-CYANOPYRAZOLE Methyl Pyrazole-3-carboxylate DIETHYL 3,5-PYRAZOLEDICARBOXYLATE 1H-PYRAZOLE-3-CARBONITRILE Pyrazinoic acid hydrazide Boric acid 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester 5-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)-1-METHYL-1H-PYRAZOLE

  • 2H-pyrazol-3-ylboronic acid
  • 3-Pyrazoleboronicacid
  • Pyrazole-5-boronic acid
  • Pyrazol-3-ylboronic acid
  • CHEMBRDG-BB 4201615
  • 1H-Pyrazole-3-boronic acid hydrate, 95%
  • 1H-PYRAZOL-3-YL BORONIC ACID
  • 1H-PYRAZOLE-3-YL BORONIC ACID
  • 1H-PYRAZOLE-3-BORONIC ACID
  • Pyrazole-3-boronic acid
  • Pyrazole-2-boronic acid
  • boronic acid, 1H-pyrazol-5-yl-
  • 1H-Pyrazole-5-boronic acid
  • 1H-Pyrazol-3-yl boronic acid ,97%
  • 1H-pyrazol-3-ylboronic acid(SALTDATA: 2H2O)
  • 2H-Pyrazole-3-boronic acid, 5-Borono-1H-pyrazole
  • 1H-Pyrazole-3(5)-boronic acid
  • 1H-Pyrazol-5-boronic acid
  • 1H-PYRAZOLE-3-BORONIC ACID; 1H-PYRAZOLE-5-BORONIC ACID
  • 1H-pyrazol-5-yl-5-boronic acid
  • Pyrazole-3-boronic acid 1H-Pyrazole-3-boronic acid
  • e-5-boronic acid
  • Boronic acid, B-1H-pyrazol-3-yl-
  • Pyrazole-3-boronicaci
  • 1H-Pyrazole-3-boronic acid hydrate, 95%,
  • (1H-Pyrazol-3-yl)boronic acid - [P10050]
  • 376584-63-3
  • C3H4BBrN2O2
  • C3H5BN2O2H2O
  • C3H5BN2O2xH2O
  • Boronic acid
  • Organoborons
  • Pyrazole
  • Boric Acid| Boric Acid Ester| Potassium Trifluoroborate