ChemicalBook > CAS DataBase List > Clobetasol

Clobetasol

Product Name
Clobetasol
CAS No.
25122-41-2
Chemical Name
Clobetasol
Synonyms
CLOBETASOLE PROPIONATE;CLOBETASOL-17-PROPIONATE;Clobetasol;ClobetasolBase;Clobetasol USP/EP/BP;Clobetasol Impurity G;CLOBESTASOL PROPIONATE;Betamethasone Impurity B;Clobetasol impurity G (PhEur);Clobetasol Propionate EP IMP G
CBNumber
CB8715108
Molecular Formula
C22H28ClFO4
Formula Weight
410.91
MOL File
25122-41-2.mol
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Clobetasol Property

Melting point:
220-222°C
Boiling point:
555.1±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
12.03±0.70(Predicted)
color 
White to Light Brown
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Safety

Hazard Codes 
T
Risk Statements 
61-48/20/21-53-62
Safety Statements 
53-36/37-45
Hazardous Substances Data
25122-41-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
C583490
Product name
Clobetasol
Packaging
100mg
Price
$1210
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024630
Product name
CLOBETASOL
Purity
95.00%
Packaging
100MG
Price
$1758.49
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
68820
Product name
Clobetasol
Packaging
100mg
Price
$2000
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
68820
Product name
Clobetasol
Packaging
10mg
Price
$625
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024630
Product name
CLOBETASOL
Purity
95.00%
Packaging
10MG
Price
$697.34
Updated
2021/12/16
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Clobetasol Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Dermovate,Glaxo,UK,1973

Uses

Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory.

Uses

Atorvastatin Intermediate

Definition

ChEBI: A 3-oxo-Delta1,Delta4-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha posit ons, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis.

Manufacturing Process

A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide (25 ml) was treated with lithium chloride (4 g) and the mixture heated on the steam bath for 30 minutes. Dilution with water gave the crude product which was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by reaction with propionic anhydride.

brand name

Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).

Therapeutic Function

Corticosteroid, Antiinflammatory

Clobetasol Preparation Products And Raw materials

Raw materials

Preparation Products

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Clobetasol Suppliers

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View Lastest Price from Clobetasol manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Betamethasone EP Impurity B 25122-41-2
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-01
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Betamethasone EP Impurity B 25122-41-2
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-01
Hebei Yanxi Chemical Co., Ltd.
Product
Clobetasol 25122-41-2
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-16

25122-41-2, ClobetasolRelated Search:

Betamethasone-17-ketone Betamethasone EP Impurity D Betamethasone Impurity 35 11-Oxo-betaMethasone Dipropionate Mometasone furoate Trimethyl borate Dexamethasone 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione Ethanone, 2-chloro-1-cyclopentyl- (9CI) CLOBETASOL PROPIONATE RELATED COMPOUND A (50 MG) (9-ALPHA-FLUORO-11-BETA-HYDROXY-16-BETA-METHYL-3-OXO-ANDROSTA-1,4-DIENE-17(R)-SPIRO-2'-[4'-CHLORO-5'-ETHYLFURAN-3'(2'H)-ONE]) Halobetasol propionate Clobetasol propionate CLOBETASOL FOR PEAK IDENTIFICATION,CLOBETASOL FOR PEAK IDENTIFICATION CLOBETASOL IMPURITY J,CLOBETASOL IMPURITY J HALOBETASOL Clobetasol fluoro jade

  • ClobetasolBase
  • Clobetasol Propionate 25122-46-7 / Base
  • 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • CLOBETASOLE PROPIONATE
  • CLOBETASOL-17-PROPIONATE
  • CLOBESTASOL PROPIONATE
  • Clobetasol (Betamethasone Impurity B)
  • (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • Clobetasol impurity G (PhEur)
  • Clobetasol Propionate Impurity 7(Clobetasol Propionate EP Impurity G)
  • 17-(2-Chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8, 11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • Clobetasol
  • Clobetasol (Betamethasone EP Impurity B)
  • Clobetasol Propionate EP Impurity G
  • Clobetasol Impurity G
  • Betamethasone Impurity 2（Betamethasone EP Impurity B）
  • Betamethasone impurity 1/Betamethasone EP Impurity B/Clobetasol/21-Chloro-9-fluoro-11?,17-dihydroxy-16?-methylpregna-1,4-diene-3,20-dione
  • Clobetasol Propionate EP IMP G
  • 21-Chloro-9-fluoro-11beta,17-dihydr
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16β)-
  • Clobetasol Propionate EP Impurity G/Betamethasone EP Impurity B
  • Clobetasol USP/EP/BP
  • Clobetasol (1.0 mg/mL in Methanol)
  • Betamethasone Impurity B
  • Clobetasol Propionate Impurity-G (EP)/ Betamethasone Impurity B (EP)
  • Betamethasone Impurity B (EP)/ Clobetasol Propionate Impurity-G (EP)
  • Clobetasol D5Q: What is Clobetasol D5 Q: What is the CAS Number of Clobetasol D5 Q: What is the storage condition of Clobetasol D5 Q: What are the applications of Clobetasol D5
  • 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Clobetasol Propionate Impurity G
  • Betamethasone EP Impurity B（Clobetasol Propionate EP Impurity G）
  • Clobetasol (Betamethasone EP Impurity B, Clobetasol Propionate EP Impurity G)
  • 1, 4-PREGNADIEN-21-CHLORO-9α-FLUORO-16β-METHYL-11β, 17α-DIOL-3, 20-DIONE
  • 21-chloro-9-uoro-11β,17-dihydroxy-16β-methylpregna- 1,4-diene-3,20-dione
  • 25122-41-2
  • C22H28ClFO4
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