ChemicalBook > CAS DataBase List > 2-Chloro-5-thiophenecarboxaldehyde

2-Chloro-5-thiophenecarboxaldehyde

Product Name
2-Chloro-5-thiophenecarboxaldehyde
CAS No.
7283-96-7
Chemical Name
2-Chloro-5-thiophenecarboxaldehyde
Synonyms
BUTTPARK 29\08-47;TIMTEC-BB SBB004100;2-Chloro-5-thiophene;oro-2-thiophenecarboxaL;Rivaroxaban Impurity 125;Rivaroxaban Impurity 100;Chlorothiophene Aldehyde;Rivaroxaban Impurity RC30;2-CHLORO-5-FORMYLTHIOPHENE;5-CHLORO-2-FORMYLTHIOPHENE
CBNumber
CB8737416
Molecular Formula
C5H3ClOS
Formula Weight
146.59
MOL File
7283-96-7.mol
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2-Chloro-5-thiophenecarboxaldehyde Property

Boiling point:
99 °C/21 mmHg (lit.)
Density 
1.376 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.604(lit.)
Flash point:
208 °F
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Crystalline Powder or Solid
color 
White to tan
Sensitive 
Air Sensitive
InChI
InChI=1S/C5H3ClOS/c6-5-2-1-4(3-7)8-5/h1-3H
InChIKey
VWYFITBWBRVBSW-UHFFFAOYSA-N
SMILES
C1(C=O)SC(Cl)=CC=1
CAS DataBase Reference
7283-96-7(CAS DataBase Reference)
NIST Chemistry Reference
2-Thiophenecarboxaldehyde, 5-chloro-(7283-96-7)
EPA Substance Registry System
2-Thiophenecarboxaldehyde, 5-chloro- (7283-96-7)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-43-36-36/37/38
Safety Statements 
36-36/37/39-26-24-37/39
RIDADR 
2810
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29124990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
443239
Product name
5-Chloro-2-thiophenecarboxaldehyde
Purity
97%
Packaging
1g
Price
$36
Updated
2023/06/20
Sigma-Aldrich
Product number
443239
Product name
5-Chloro-2-thiophenecarboxaldehyde
Purity
97%
Packaging
5g
Price
$96.5
Updated
2023/06/20
TCI Chemical
Product number
C1722
Product name
5-Chlorothiophene-2-carboxaldehyde
Purity
>95.0%(GC)
Packaging
1g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
C1722
Product name
5-Chlorothiophene-2-carboxaldehyde
Purity
>95.0%(GC)
Packaging
5g
Price
$105
Updated
2025/07/31
TRC
Product number
C428782
Product name
5-Chloro-2-thiophenecarboxaldehyde
Packaging
1g
Price
$55
Updated
2021/12/16
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2-Chloro-5-thiophenecarboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

5-Chloro-2-thiophenecarboxaldehyde is used in the evaluation of 2-benzylidene-1-tetralone derivative as antagonists of A1 and A2A adenosine receptors.

Uses

5-Chloro-2-thiophenecarboxaldehyde may be used for synthesis of 2-heteroaryl-α-methyl-5-benzoxazoleacetic acids and N,N′-bis[(E)-(5-chloro-2-thienyl)methylidene]ethane-1,2-diamine

General Description

5-Chloro-2-thiophenecarboxaldehyde is a thiophene derivative.

Synthesis

17249-82-0

7283-96-7

GENERAL METHOD: 2-chloro-5-methylthiophene (200 mmol) was dissolved in anhydrous DMF (43.86 g, 600 mmol) under anhydrous conditions, cooled in an ice-water bath and stirred. POCl3 (46.00 g, 300 mmol) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was continued to be stirred at the temperature of the ice-water bath for 30 min, and then warmed up to 100 °C for 5 h. The reaction was carried out at the temperature of the ice-water bath. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water (300 mL). The aqueous phase was extracted with dichloromethane (300 mL × 3) and the organic phase was combined. The organic phase was washed sequentially with 5% brine (200 mL), 10% aqueous K2CO3 (200 mL), and 5% brine (200 mL), and then dried with anhydrous Na2SO4. The solvent was evaporated under reduced pressure to obtain the crude product. Purification of the crude product by column chromatography afforded the target compound 5-chlorothiophene-2-carbaldehyde (10ha): a colorless oil in 22.00 g (75%) yield.1H-NMR (DMSO-d6, 400 MHz) δ: 9.82 (s, 1H), 7.95 (d, J = 4.0 Hz, 1H), 7.39 (d, J = 4.0 Hz, 1H). The obtained 1H-NMR data are in agreement with literature reports [53].

References

[1] Molecules, 2018, vol. 23, # 2,
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 988

2-Chloro-5-thiophenecarboxaldehyde Preparation Products And Raw materials

Raw materials

2-Chlorothiophene N,N-Dimethylformamide Phosphorus oxitrichloride N-Methylformanilide

Preparation Products

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2-Chloro-5-thiophenecarboxaldehyde Suppliers

Americas 1 Belgium 5 Canada 1 China 208 Europe 3 France 1 Germany 6 India 11 Japan 4 Slovakia 2 Switzerland 4 The Netherlands 1 Ukraine 2 United Kingdom 20 United States 48 Global 317
BIOSYNTH AG
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welcome@biosynth.ch
Country
Switzerland
ProdList
1308
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60
Matrix Fine Chemicals GmbH
Tel
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Fax
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Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
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Chemodex Ltd.
Tel
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Email
info@chemodex.com
Country
Switzerland
ProdList
1549
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50
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 2-Chloro-5-thiophenecarboxaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-5-thiophenecarboxaldehyde 7283-96-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000tons
Release date
2025-04-10
Henan Aochuang Chemical Co.,Ltd.
Product
2-Chloro-5-thiophenecarboxaldehyde 7283-96-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Rivaroxaban Impurity 91 7283-96-7
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-08

7283-96-7, 2-Chloro-5-thiophenecarboxaldehydeRelated Search:

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  • 5-CHLOROTHIOPHENE-2-CARBALDEHYDE
  • 5-CHLOROTHIOPHENE-2-CARBOXALDEHYDE
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  • CHIRAL CHEMICALS
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