3-METHYL-2-PYRROLIDINONE

Product Name: 3-METHYL-2-PYRROLIDINONE
CAS No.: 2555-05-7
Chemical Name: 3-METHYL-2-PYRROLIDINONE
Synonyms: 3-methylpyrrolidin-2-one;α-Methylbutyrolactam;3-Methyl-2-pyrrolidone;3-METHYL-2-PYRROLIDINONE;alpha-Methylbutyrolactame;2-Pyrrolidinone,3-methyl-;(R,S)-3-Methyl-pyrrolidin-2-one;alpha-Methylbutyrolactam~3-Methyl-2-pyrrolidone
CBNumber: CB8756738
Molecular Formula: C5H9NO
Formula Weight: 99.13
MOL File: 2555-05-7.mol

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3-METHYL-2-PYRROLIDINONE Property

Melting point:: 55°C
Boiling point:: 118-120 °C(Press: 10 Torr)
Density: 0.979±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 16.66±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Y8455
Product name: 3-Methylpyrrolidin-2-one
Packaging: 100mg
Price: $109
Updated: 2021/12/16

Matrix Scientific

Product number: 085718
Product name: 3-Methylpyrrolidin-2-one
Purity: 97%
Packaging: 1g
Price: $249
Updated: 2021/12/16

AK Scientific

Product number: Y8455
Product name: 3-Methylpyrrolidin-2-one
Packaging: 10g
Price: $1432
Updated: 2021/12/16

Matrix Scientific

Product number: 085718
Product name: 3-Methylpyrrolidin-2-one
Purity: 97%
Packaging: 10g
Price: $1932
Updated: 2021/12/16

CHESS

Product number: 3564
Product name: 3-Methyl-pyrrolidin-2-one
Purity: 98
Packaging: 1g
Price: $12000
Updated: 2021/12/16

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3-METHYL-2-PYRROLIDINONE Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron, 43, p. 1811, 1987 DOI: 10.1016/S0040-4020(01)81492-7

Synthesis

108303-99-7

2555-05-7

1-Benzyl-3-methylpyrrolidin-2-one (0.323 g, 1.7 mmol, 1.0 eq.) was used as a starting material and dissolved in toluene (2 mL, 1 M). Trifluoromethanesulfonic acid (0.604 mL, 6.8 mmol, 4.0 eq.) was added to this solution. The reaction mixture was placed in a microwave reactor and heated at 195°C for 25 minutes. Upon completion of the reaction, the mixture was poured into a small amount of saturated aqueous sodium bicarbonate solution for neutralization. The aqueous phase was extracted with ethyl acetate and the organic phase was again washed with saturated aqueous sodium chloride solution. The combined aqueous phases were again extracted with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by silica gel column chromatography with a gradient of dichloromethane solution of 0-10% methanol as eluent to give 3-methyl-2-pyrrolidinone (0.087 g). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.49 (br s, 1H), 3.37-3.26 (m, 2H), 2.53-2.28 (m, 2H), 1.80-1.65 (m, 1H), 1.21-1.19 (d, 3H, J = 6.6 Hz).

References

[1] Patent: US2015/284362, 2015, A1. Location in patent: Paragraph 0299
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 3, p. 293 - 297

3-METHYL-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-METHYL-2-PYRROLIDINONE Suppliers

China 67 Germany 2 India 2 United Kingdom 6 United States 8 Global 85

MOLEKULA Ltd.

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Atlantic Research Chemicals Ltd.

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CARBONE SCIENTIFIC CO.,LTD

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ETA SCIENTIFIC Co.,Ltd

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UK GREEN SCIENTIFIC CO.,LIMITED

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VWR International

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View Lastest Price from 3-METHYL-2-PYRROLIDINONE manufacturers

Shanghai Rlavie Technology Co ltd

Product: 3-Methyl-2-pyrrolidinon 2555-05-7
Price: US $0.00/KG
Min. Order: 0.0001KG
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-05-10

2555-05-7, 3-METHYL-2-PYRROLIDINONERelated Search:

CAPTAFOL DIHYDROCYTOCHALASIN B CYTOCHALASIN E CYTOCHALASIN C 1-methyl-3-pyrrolidinone ALPHA-METHYL-ALPHA-PROPYLSUCCINIMIDE CYTOCHALASIN A 1,2-Cyclohexanedicarboximide Cytochalasin H CIS-1,2,3,6-TETRAHYDROPHTHALIMIDE 3-METHYL-2-PYRROLIDINONE N-Methyl-2-pyrrolidone L-Pyroglutaminol (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate 1-METHYL-3-TRIFLUOROMETHYL-2-PYRAZOLIN-5-ONE 5-METHYL-2-PYRROLIDINONE 4-methyl-2-Pyrrolidinone 3-AMINO-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXY

(R,S)-3-Methyl-pyrrolidin-2-one

2-Pyrrolidinone,3-methyl-

3-methylpyrrolidin-2-one

α-Methylbutyrolactam

3-METHYL-2-PYRROLIDINONE

alpha-Methylbutyrolactam~3-Methyl-2-pyrrolidone

alpha-Methylbutyrolactame

3-Methyl-2-pyrrolidone

2555-05-7

Pyrrolidines