5-METHOXY-PYRIDINE-3-CARBALDEHYDE

Uses

Product Name: 5-METHOXY-PYRIDINE-3-CARBALDEHYDE
CAS No.: 113118-83-5
Chemical Name: 5-METHOXY-PYRIDINE-3-CARBALDEHYDE
Synonyms: 5-METHOXYNICOTINALDEHYDE;3-FORMYL-5-METHOXYPYRIDINE;3-ForMyl-5-Methoxypyridin...;5-Methoxynicotinaldehyde 97%;5-Methoxypyridin-3-carbaldehyde;5-Methoxy-pyridinecarboxaldehyde;5-Methoxy-3-pyridinecarbaldehyde;5-methxoypyridine-3-carbaldehyde;5-METHOXY-PYRIDINE-3-CARBALDEHYDE;-Methoxy-3-pyridinecarboxaldehyde
CBNumber: CB8764353
Molecular Formula: C7H7NO2
Formula Weight: 137.14
MOL File: 113118-83-5.mol

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5-METHOXY-PYRIDINE-3-CARBALDEHYDE Property

Melting point:: 28-32 °C
Boiling point:: 262.1±20.0 °C(Predicted)
Density: 1.159±0.06 g/cm3(Predicted)
Flash point:: 100 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 2.52±0.10(Predicted)
Appearance: Colorless to light yellow <28°C Solid,>32°C Liquid
InChI: InChI=1S/C7H7NO2/c1-10-7-2-6(5-9)3-8-4-7/h2-5H,1H3
InChIKey: YOVIXSRXKCZJRN-UHFFFAOYSA-N
SMILES: C1=NC=C(OC)C=C1C=O

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-43
Safety Statements: 36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M332958
Product name: 5-Methoxy-3-pyridinecarboxaldehyde
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 026164
Product name: 5-Methoxy-pyridine-3-carbaldehyde
Packaging: 250mg
Price: $13
Updated: 2021/12/16

Matrix Scientific

Product number: 026164
Product name: 5-Methoxy-pyridine-3-carbaldehyde
Packaging: 500mg
Price: $20
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: F10272
Product name: 3-Formyl-5-methoxypyridine
Purity: 98%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: F10272
Product name: 3-Formyl-5-methoxypyridine
Purity: 98%
Packaging: 5g
Price: $70
Updated: 2021/12/16

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5-METHOXY-PYRIDINE-3-CARBALDEHYDE Chemical Properties,Usage,Production

Uses

5-Methoxy-pyridine-3-carboxaldehyde is mainly used as an organic synthesis intermediate and can be used to synthesize various organic molecules containing a pyridine skeleton. Its highly reactive aldehyde group makes it an important starting material for synthesizing complex molecules.

Chemical Properties

White to yellow to orange to brown solid

Synthesis

50720-12-2

68-12-2

113118-83-5

3-Bromo-5-methoxypyridine (100 mg, 0.53 mmol) was placed in an oven-dried round-bottomed flask equipped with a magnetic stir bar and dissolved in anhydrous tetrahydrofuran (1 mL). Subsequently, isopropylmagnesium chloride (0.3 mL) was added at 0 °C and the resulting mixture was stirred at room temperature for 2 h (the solution turned light brown). Then, anhydrous tetrahydrofuran (0.1 mL) solution of N,N-dimethylformamide (0.1 mL) was slowly added. The initially formed solid gradually dissolved and the color of the solution changed from light brown to light yellow. after 1 h, the reaction mixture was cooled to 0 °C and the reaction was quenched with deionized water (2 mL). The organic layer was separated and the aqueous layer was further extracted with dichloromethane (3 x 3 mL). The organic layers were combined and dried over anhydrous sodium sulfate and subsequently concentrated in vacuum on a rotary evaporator. The crude product was purified by gradient silica gel column chromatography with the eluent being a solvent mixture of hexane and ethyl acetate (ratio from 20:1 to 1:1) to afford the target product 5-methoxy-pyridine-3-carbaldehyde as a colorless slurry (45 mg, 63% yield).1H NMR (500 MHz, CDCl3): δ 10.09 (s, 1H), 8.65 (d, J = 0.9 Hz, 1H), 8.54 (d, J = 3.1 Hz, 1H), 7.60 (dd, J = 5.1, 1.5 Hz, 1H).13C NMR (125 MHz, CDCl3): δ 190.6, 156.2, 145.1, 144.8, 132.0, 116.3, 55.7.

References

[1] Tetrahedron Letters, 2005, vol. 46, # 11, p. 1867 - 1871
[2] Tetrahedron, 2001, vol. 57, # 20, p. 4447 - 4454
[3] Biochemistry, 2010, vol. 49, # 49, p. 10421 - 10439
[4] Patent: US2014/309427, 2014, A1. Location in patent: Paragraph 0157; 0158
[5] Patent: WO2007/84560, 2007, A2. Location in patent: Page/Page column 164

5-METHOXY-PYRIDINE-3-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

3,5-Dibromopyridine N,N-Dimethylformamide Sodium Methoxide Tetrahydrofuran n-Butyllithium

Preparation Products

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5-METHOXY-PYRIDINE-3-CARBALDEHYDE Suppliers

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View Lastest Price from 5-METHOXY-PYRIDINE-3-CARBALDEHYDE manufacturers

Dideu Industries Group Limited

Product: 5-METHOXY-PYRIDINE-3-CARBALDEHYDE 113118-83-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-METHOXY-PYRIDINE-3-CARBALDEHYDE 113118-83-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 5-METHOXY-PYRIDINE-3-CARBALDEHYDE 113118-83-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-14

113118-83-5, 5-METHOXY-PYRIDINE-3-CARBALDEHYDERelated Search:

5-METHOXYPICOLINALDEHYDE 5-METHOXYPYRIDINE-2-CARBOXYLIC ACID 5-METHOXY-PYRIDIN-3-OL (5-METHOXYPYRIDIN-2-YL)METHANOL 5-Methoxypyridine-3-boronic acid 5-Methoxy-3-pyridinemethanamine 4-Iodo-2-methoxypyridine-3-carboxaldehyde 2,6-DIMETHOXYISONICOTINALDEHYDE 5-METHOXY-PYRIDINE-3-CARBALDEHYDE 3-METHOXY-PYRIDINE-2-CARBALDEHYDE 3-CHLORO-2-METHOXYBENZALDEHYDE 2-BROMO-3-METHOXYPYRIDINE-4-CARBOXALDEHYDE 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE 6-METHOXY-PYRIDINE-3-CARBALDEHYDE 2-Methoxy-pyridine-4-carbaldehyde 6-Methoxypyridine-2-carbaldehyde 5-BROMO-2-METHOXY-PYRIDINE-3-CARBALDEHYDE 2-METHOXY-PYRIDINE-3-CARBALDEHYDE

3-FORMYL-5-METHOXYPYRIDINE

5-METHOXY-3-PYRIDINECARBOXALDEHYDE

5-METHOXYNICOTINALDEHYDE

5-METHOXY-PYRIDINE-3-CARBALDEHYDE

5-Methoxypyridine-3-carboxaldehyde

3-Pyridinecarboxaldehyde,5-methoxy-(9CI)

3-METHOXY-5-PYRIDINECARBOXALDEHYDE

5-methoxy-3-pyridinecorbaxaldehyde

BP1106 3-Methoxy-5-pyridinecarboxaldehyde

5-Methoxy-3-pyridinecarboxaldehyde ,98%

3-ForMyl-5-Methoxypyridin...

5-Methoxynicotinaldehyde 97%

5-Methoxypyridine-3-carboxaldehyde, 3-Formyl-5-methoxypyridine

5-Methoxy-pyridinecarboxaldehyde

5-Methoxy-3-pyridinecarbaldehyde

5-Methoxypyridin-3-carbaldehyde

5-methxoypyridine-3-carbaldehyde

3-Pyridinecarboxaldehyde, 5-methoxy-

5-METHOXY-PYRIDINE-3-CARBALDEHYDE ISO 9001：2015 REACH

-Methoxy-3-pyridinecarboxaldehyde

113118-83-5

Heterocycle-Pyridine series

Building Blocks

C7 and C8

Heterocyclic Building Blocks

Aldehydes

Pyridines

Heterocyclic Compounds

PYRIDINE