ChemicalBook > CAS DataBase List > 1-Hydroxybenzotriazole hydrate

1-Hydroxybenzotriazole hydrate

Product Name
1-Hydroxybenzotriazole hydrate
CAS No.
123333-53-9
Chemical Name
1-Hydroxybenzotriazole hydrate
Synonyms
1-HYDROXYBENZOTRIAZOLE MONOHYDRATE;HOBT H2O;HOBT HYDRATE;HOBT.H20;1H-benzo[d][1,2,3]triazol-1-ol hydrate;N-HYDROXYBENZOTRIAZOLE HYDRATE;HOBTM;e hydrate;CAS:123333-53-9;HOBT MONOHYDRATE
CBNumber
CB8775919
Molecular Formula
C6H7N3O2
Formula Weight
153.14
MOL File
123333-53-9.mol
More
Less

1-Hydroxybenzotriazole hydrate Property

Melting point:
155-158 °C(lit.)
Boiling point:
248.8°C (rough estimate)
Density 
1.065 g/cm
refractive index 
1.6910 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMF: 100 mg/mL, clear
form 
Solid
color 
White to Off-White
Water Solubility 
slightly soluble
BRN 
4515
Stability:
Hygroscopic
InChI
InChI=1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
InChIKey
PJUPKRYGDFTMTM-UHFFFAOYSA-N
SMILES
ON1N=NC2C=CC=CC1=2.O
CAS DataBase Reference
123333-53-9(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
F
Risk Statements 
5-11-R5-R11-44-1
Safety Statements 
15-16-35-7/9-33-S7/9-S33-S16-60-37-26
RIDADR 
UN 3380 4.1/PG 1
WGK Germany 
-
F 
4.10-8
Hazard Note 
Highly Flammable
HazardClass 
4.1
HS Code 
29339980
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P230Keep wetted with …

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P380+P375in case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
157260
Product name
1-Hydroxybenzotriazole hydrate
Purity
wetted with not less than 14 wt. % water, 97%
Packaging
25g
Price
$83.6
Updated
2025/07/31
Sigma-Aldrich
Product number
157260
Product name
1-Hydroxybenzotriazole hydrate
Purity
wetted with not less than 14 wt. % water, 97%
Packaging
100g
Price
$187.15
Updated
2025/07/31
Sigma-Aldrich
Product number
711489
Product name
1-Hydroxybenzotriazole hydrate
Purity
wetted with not less than 20 wt. % water, 97%
Packaging
50g
Price
$137
Updated
2025/07/31
Sigma-Aldrich
Product number
711489
Product name
1-Hydroxybenzotriazole hydrate
Purity
wetted with not less than 20 wt. % water, 97%
Packaging
250g
Price
$464
Updated
2025/07/31
Sigma-Aldrich
Product number
711489
Product name
1-Hydroxybenzotriazole hydrate
Purity
wetted with not less than 20 wt. % water, 97%
Packaging
1kg
Price
$1440
Updated
2025/07/31
More
Less

1-Hydroxybenzotriazole hydrate Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:

  • Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
  • Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.

Uses

A common additive for peptide coupling.

Uses

1-Hydroxybenzotriazole hydrate is used as an additive for oligonucleotide couplings and in racemization-free peptide couplings.

General Description

1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.

reaction suitability

reaction type: Addition Reactions

Toxics Screening Level

The ITSL 1-Hydroxy benzotriazole has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.

1-Hydroxybenzotriazole hydrate Preparation Products And Raw materials

Raw materials

4-Methylmorpholine

Preparation Products

Cefodizime
More
Less

1-Hydroxybenzotriazole hydrate Suppliers

Austria 1 Belgium 2 Canada 2 China 344 Europe 4 France 2 Germany 6 India 25 Israel 2 Japan 7 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 The Netherlands 1 United Kingdom 19 United States 50 Global 471
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Anisyn, Inc.
Tel
--
Fax
--
Email
sales@anisyn.com
Country
United States
ProdList
863
Advantage
0
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
AAPPTEC
Tel
--
Fax
--
Email
info@aapptec.com
Country
United States
ProdList
533
Advantage
0
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Magical Scientific LLC
Tel
--
Fax
--
Country
United States
ProdList
703
Advantage
0
CreoSalus Inc.
Tel
--
Fax
--
Email
ckalmer@creosalus.com
Country
United States
ProdList
310
Advantage
30
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Jupiter Bioscience Limited
Tel
--
Fax
--
Email
vksaipriya@jupiterbioscience.com
Country
United States
ProdList
247
Advantage
68
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Peptides International, Inc.
Tel
--
Fax
--
Email
peptides@pepnet.com
Country
United States
ProdList
555
Advantage
72
Amber Synthetics, Amsyn Inc.
Tel
--
Fax
--
Email
mail@amsyn.com
Country
United States
ProdList
194
Advantage
46
Dudley Chemical Corp.
Tel
--
Fax
--
Email
dudley@dudley-chem.com
Country
United States
ProdList
687
Advantage
64
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
Advanced Scientific Internatiional,LLC
Tel
--
Fax
--
Email
webmaster@adscientific.net
Country
United States
ProdList
133
Advantage
30
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Fisher Scientific
Tel
--
Fax
--
Email
sales@fishersci.com
Country
United States
ProdList
2337
Advantage
86
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
AcceleDev Chemical LLC
Tel
--
Fax
--
Email
info@acceledev.com
Country
United States
ProdList
632
Advantage
42
Advanced Asymmetrics, Inc.
Tel
--
Fax
--
Email
sales@advancedasymmetrics.com
Country
United States
ProdList
521
Advantage
42
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Magical Scientific LLP
Tel
--
Fax
--
Country
United States
ProdList
750
Advantage
43
Lacamas Laboratories
Tel
--
Fax
--
Email
sales@lacamaslaboratories.com
Country
United States
ProdList
17
Advantage
54
Advanced ChemTech
Tel
--
Fax
--
Country
United States
ProdList
1606
Advantage
69
PE Biosystems
Tel
--
Fax
--
Country
United States
ProdList
173
Advantage
58
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Davos Chemical Corporation
Tel
--
Fax
--
Email
info@davos.com
Country
United States
ProdList
1640
Advantage
65
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
More
Less

View Lastest Price from 1-Hydroxybenzotriazole hydrate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-Hydroxybenzotriazole hydrate 123333-53-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20T
Release date
2025-08-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-Hydroxybenzotriazole hydrate 123333-53-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-03
Hebei Chuanghai Biotechnology Co., Ltd
Product
1-Hydroxybenzotriazole hydrate 123333-53-9
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-23

123333-53-9, 1-Hydroxybenzotriazole hydrateRelated Search:

2'-Hydroxy-3-phenylpropiophenone 4-Hydroxy-D-(-)-2-phenylglycine 2-Hydroxyphenylacetic acid Triclosan Methylparaben 4-Hydroxybenzaldehyde 4-Methoxyphenol 4'-Hydroxyacetophenone 4-Hydroxybenzoic acid Chloral hydrate 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate BIS(HYDROXYBENZOTRIAZOLYL) CARBONATE 6-Chloro-1-hydroxibenzotriazol (Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate 1-HYDROXY-6-(TRIFLUOROMETHYL)BENZOTRIAZOLE TBTU 1-Hydroxybenzotriazole

  • HOBTM
  • HOBT HYDRATE
  • HOBT H2O
  • 1H-1,2,3-benzotriazol-1-ol hydrate solution
  • 1-HYDROXYBENZOTRIAZOLE 15 WT. % SOLUTI&
  • 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate
  • 1H-benzo[d][1,2,3]triazol-1-ol hydrate
  • HOBT.H2O1-Hydroxybenzotriazole hydrate
  • 1-Hydroxybenzotriazole hydrate wetted with not less than 20 wt. % water, 97%
  • 1-Hydroxybenzotriazole hydrate HOBT hydrate
  • 1-Hydroxybenzotriazole hydrate >=97.0% (T)
  • HOBT monohydrate (1-hydroxybenzotriazole.H2O)
  • 1-Hydroxybenzotriazole hydrate(< 5 ppm hydrazine)wetted with not less than 20 wt. % water≥ 99% (HPLC)
  • HOBt hydrate (<5 ppm hydrazine)
  • N-HYDROXYBENZOTRIAZOL MONOHYDRATE
  • N-HYDROXYBENZOTRIAZOLE MONOHYDRATE
  • N-HYDROXYBENZOTRIAZOLE HYDRATE
  • N-HYDROXYBENZOTRIAZOLE H2O
  • TIMTEC-BB SBB000114
  • e hydrate
  • 1-Hydroxybenzotriazole99%Puriss
  • 1-Hydroxybenzotriazole hydrate, ca. 6% water, 98%
  • Hydroxy-1,2,3-Benzotriazole 2592-95-2
  • 1-HYDROXY BENZOTRIAZOLE MONOHYDATE
  • HOBt(hydrate) N-Hydroxybenzotnazole Hydrate
  • 1-HYDROXYBENZOTRIAZOLE HYDRATE (WATER CONTENT BETWEEN 10-13%)
  • 1-Hydroxybenzotriazole Monohydrous
  • 1-Hydroxybenzotriazole Hyrate
  • 1-Hydroxybenzotriazole hydrate, contains 11-16% water, 98%
  • 1-Hydroxybenzotriazole (HOBt) hydrate
  • 1-Hydroxybenzotriazole hydrate (HOBt)
  • N-Hydroxybenzotriazole monohydrate (HOBt)
  • 1-Hydroxy-1H-benzotriazole Hydrate
  • 1-Oxy-benztriazol Hydrate
  • Benzotriazol-1-ol Hydrate
  • 1-Hydroxybenzotriazole hydrate, 98% (dry wt), water >20%
  • 1-Hydroxybenzotriazole hydrate ,99%
  • 1-HYDROXYBENZOTRIAZOLE HYDRATE, 98%, CONTAINS 11-16% WATER
  • HOBT.H20
  • 1-Hydroxybenzotriazole hydrate ,98%
  • N-Hydroxybenzotrizole Monohydrate
  • 1H-1,2,3-benzotriazole-1,4-diol
  • 1H-1,2,3-BENZOTRIAZOL-1-OL HYDRATE
  • 1H-BENZOTRIAZOLE, 1-HYDROXY-, HYDRATE
  • 1-HYDROXYBENZOTRIAZOL MONOHYDRATE
  • 1-HYDROXYBENZOTRIAZOLE N-HYDRATE
  • 1-HYDROXYBENZOTRIAZOLE MONOHYDRATE
  • 1-HYDROXYBENZOTRIAZOLE HYDRATE
  • HOBT MONOHYDRATE
  • HOBT hydrate [1-Hydroxybenzotriazole hydrate]
  • 1-Hydroxybenzotriazole Hydrat
  • HOBT.H20 1-Hydroxybenzotriazole hydrate
  • 1,2,3-BENZOTRIAZOL-1-OL MONOHYDRATE
  • HOBT.H20 1-Hydroxybenzotriazole hydrate,≥97.0%
  • 1-Hydroxybenzotriazole hydrate USP/EP/BP
  • HoBt.H2O [ 123333-53-9
  • HOBT,1-Hydroxybenzotriazole hydrate
  • HOBT Monohydrate pure, 99%