ChemicalBook > CAS DataBase List > 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE

Product Name
4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
CAS No.
171745-13-4
Chemical Name
4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
Synonyms
EGFR-IN-80;COMPOUND 56;N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine;N-(3-broMophenyl)-6,7-diethoxyquinazolin-4-aMine;4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE;4-Quinazolinamine, N-(3-bromophenyl)-6,7-diethoxy-
CBNumber
CB8784430
Molecular Formula
C18H18BrN3O2
Formula Weight
388.26
MOL File
Mol file
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4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Property

storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form 
White to off-white powder.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
17254
Product name
Compound 56
Purity
≥95%
Packaging
500μg
Price
$238
Updated
2024/03/01
Cayman Chemical
Product number
17254
Product name
Compound 56
Purity
≥95%
Packaging
1mg
Price
$452
Updated
2024/03/01
AK Scientific
Product number
0335CA
Product name
N-(3-Bromophenyl)-6,7-diethoxyquinazolin-4-amine
Packaging
1mg
Price
$600
Updated
2021/12/16
ApexBio Technology
Product number
A8197
Product name
Compound56
Packaging
1unit
Price
$28
Updated
2021/12/16
ApexBio Technology
Product number
A8197
Product name
Compound56
Packaging
500ug
Price
$50
Updated
2021/12/16
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4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Chemical Properties,Usage,Production

Uses

Compound 56 is a potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor.

Biological Activity

compound 56, 4-[(3-bromophenyl)amino]-6,7-diethoxyquinazoline, is a potent and specific inhibitor of the tyrosine kinase of the epidermal growth factor receptor (egfr) showing an ic50 of 0.006 nm. it competitively binds at the adenosine-triphosphate (atp) site of egfr. compound 56 is capable of inhibiting the phosphorylation of egf-dependent egfr, suppressing the proliferation and clonogenicity of a wide panel of egfr-overexpressing human cancer lines, and blocking egf-mediated mitogenesis and oncogenic transformation in fibroblasts overexpressing egfr. besides inhibiting egfr tyrosine kinase, it also inhibits the tyrosine kinase of human epidermal growth factor receptor 2 (her2/neu) but with a less potency.bridges aj, zhou h, cody dr, rewcastle gw, mcmichael a, showalter hd, fry dw, kraker aj, and denny wa. tyrosine kinase inhibitors. 8. an unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (pd 153035), a potent inhibitor of the epidermal growth factor receptor.j med chem 1966; 39 (1): 267-276monique bos, jhn mendelsohn, young-mee kim, joan albanell, david w. fry, and jose baelga. pd153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. clin cancer res 1997;3:2099-2106

target

EGFR

IC 50

EGFR: 10.6 (pIC50)

4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Suppliers

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171745-13-4, 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINERelated Search:

TYRPHOSTIN B48 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- PD168393 TYRPHOSTIN A51 AG 213 CIVENTICHEM CV-409 AG 1478 HYDROCHLORIDE DAPH AG 18 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH AG 825 TYRPHOSTIN A25 Canertinib

  • COMPOUND 56
  • 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
  • N-(3-broMophenyl)-6,7-diethoxyquinazolin-4-aMine
  • N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine
  • 4-Quinazolinamine, N-(3-bromophenyl)-6,7-diethoxy-
  • EGFR-IN-80
  • 171745-13-4
  • Inhibitor