ChemicalBook > CAS DataBase List > TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

Product Name: TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
CAS No.: 893566-75-1
Chemical Name: TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
Synonyms: N-Boc-8-Bromo-1,2,3,4-tetrahydroisoquinoline;N-BOC-1,2,3,4-tetrahydro-8-broMo-isoquinoline;2-BOC-8-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;2(1H)-Isoquinolinecarboxylic acid, 8-bromo-3,4-dihydro-, 1,1-dimethylethyl ester
CBNumber: CB8784869
Molecular Formula: C14H18BrNO2
Formula Weight: 312.2
MOL File: 893566-75-1.mol

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TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Property

Boiling point:: 382.4±42.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -1.60±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000379019
Product name: Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 98%
Packaging: 100mg
Price: $16
Updated: 2021/12/16

Ark Pharm

Product number: P000379019
Product name: Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 98%
Packaging: 250mg
Price: $26
Updated: 2021/12/16

Ark Pharm

Product number: P000379019
Product name: Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 98%
Packaging: 1g
Price: $53
Updated: 2021/12/16

AK Scientific

Product number: 4762AC
Product name: Tert-butyl8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Packaging: 250mg
Price: $186
Updated: 2021/12/16

Ark Pharm

Product number: P000379019
Product name: Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 98%
Packaging: 5g
Price: $202
Updated: 2021/12/16

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TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Chemical Properties,Usage,Production

Uses

tert-Butyl 8-Bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is an Amide compound; having BET proteolysis-inducing action, and medicinal application thereof.

Synthesis

24424-99-5

75416-51-2

893566-75-1

Di-tert-butyl dicarbonate (Boc2O, 25.73 g, 117.88 mmol) was added slowly and dropwise at 0 °C to dichloromethane (DCM, containing 8-bromo-1,2,3,4-tetrahydroisoquinoline (Intermediate 21, 25.00 g, 117.88 mmol) and triethylamine (TEA, 32.83 mL, 236.00 mmol) in a 300 mL) solution. The reaction mixture was stirred continuously for 30 minutes at room temperature. Upon completion of the reaction, citric acid solution was added to quench the reaction, followed by a layering operation. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 3/1, v/v) to afford N-boc-8-bromo-1,2,3,4-tetrahydroisoquinoline (Intermediate 22, 35 g, 95% yield).

References

[1] Patent: WO2017/216293, 2017, A1. Location in patent: Page/Page column 74; 75

TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Suppliers

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View Lastest Price from TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 893566-75-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-14

893566-75-1, TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATERelated Search:

tert-Butyl 4-methylenepiperidine-1-carboxylate TERT-BUTYL [4-(CHLOROSULFONYL)PHENYL]CARBAMATE tert-butyl 4-phenethylpiperidine-1-carboxylate TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE TERT-BUTYL 8-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE 5-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER (2-BROMO-BENZYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER 8-bromo-1,2,3,4-tetrahydroisoquinoline N-(TERT-BUTOXYCARBONYL)-2-BROMOBENZYLAMINE TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

2-BOC-8-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

N-BOC-1,2,3,4-tetrahydro-8-broMo-isoquinoline

2(1H)-Isoquinolinecarboxylic acid, 8-bromo-3,4-dihydro-, 1,1-dimethylethyl ester

N-Boc-8-Bromo-1,2,3,4-tetrahydroisoquinoline

893566-75-1