ChemicalBook > CAS DataBase List > 4'-Hydroxypropiophenone

4'-Hydroxypropiophenone

Product Name
4'-Hydroxypropiophenone
CAS No.
70-70-2
Chemical Name
4'-Hydroxypropiophenone
Synonyms
PHP;b360;B 360;H-365;Mepal;Frenon;Paroxon;VANATONE;Bio-Fren;Hypostat
CBNumber
CB8854142
Molecular Formula
C9H10O2
Formula Weight
150.17
MOL File
70-70-2.mol
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4'-Hydroxypropiophenone Property

Melting point:
36-38 °C(lit.)
Boiling point:
152-154 °C26 mm Hg(lit.)
Density 
1.09 g/cm3 (20℃)
refractive index 
1.5360 (estimate)
FEMA 
2005 | ACETANISOLE
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
methanol: 0.1 g/mL, clear
pka
8.87±0.26(Predicted)
form 
Solid
color 
White
Water Solubility 
0.34 g/l (15 ºC)
Merck 
14,7044
BRN 
907511
LogP
2.030
CAS DataBase Reference
70-70-2(CAS DataBase Reference)
NIST Chemistry Reference
1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2)
EPA Substance Registry System
1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38
Safety Statements 
37-24/25-36-26
WGK Germany 
3
RTECS 
UH1925000
TSCA 
Yes
HS Code 
29145000
Toxicity
LD50 orally in Rabbit: 11800 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H55405
Product name
4′-Hydroxypropiophenone
Purity
98%
Packaging
100g
Price
$39.96
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20692
Product name
4′-Hydroxypropiophenone
Purity
for synthesis
Packaging
100g
Price
$70.4
Updated
2024/03/01
TCI Chemical
Product number
H0299
Product name
4'-Hydroxypropiophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
H0299
Product name
4'-Hydroxypropiophenone
Purity
>98.0%(GC)
Packaging
500g
Price
$161
Updated
2024/03/01
Alfa Aesar
Product number
A15314
Product name
4'-Hydroxypropiophenone, 99%
Packaging
100g
Price
$41.65
Updated
2024/03/01
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4'-Hydroxypropiophenone Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

gonadotropic hormone inhibitor

Uses

Intermediates of Liquid Crystals

Uses

p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product.

Definition

ChEBI: P-Hydroxypropiophenone is a member of acetophenones.

Preparation

Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528

Safety Profile

Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

target

Estrogen receptor

Purification Methods

4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]

4'-Hydroxypropiophenone Preparation Products And Raw materials

Raw materials

Carbon disulfide phenyl propionate

Preparation Products

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4'-Hydroxypropiophenone Suppliers

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View Lastest Price from 4'-Hydroxypropiophenone manufacturers

Dorne Chemical Technology co. LTD
Product
4'-Hydroxypropiophenone 70-70-2
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 ton
Release date
2024-03-26
Hebei Weibang Biotechnology Co., Ltd
Product
4'-Hydroxypropiophenone 70-70-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
Shaanxi Dideu Medichem Co. Ltd
Product
4'-Hydroxypropiophenone 70-70-2
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10
Release date
2024-08-04

70-70-2, 4'-HydroxypropiophenoneRelated Search:

3-(4-Hydroxyphenyl)propionic acid 2-(4-HYDROXYPHENYL)PROPIONIC ACID α-Acetylamino-hydroxy-p-nitropriophenone 4-Hydroxybenzaldehyde 4'-Hydroxyacetophenone 4-Methoxyphenol 4'-Hydroxyvalerophenone Methylparaben Methyl 3-(4-hydroxyphenyl)propionate 4,4'-Oxydiphenol 4-Hydroxyphenethyl alcohol Sodium 4-hydroxybenzenesulfonate 4-Hydroxyphenylacetic acid Tyramine 4-CHLORO-4'-HYDROXYBUTYROPHENONE Methyl 4-hydroxyphenylacetate 4-Hydroxybenzyl alcohol 4-Hydroxyphenylpyruvic acid Para Methoxy Acetophenone

  • PARA-ETHYLKETOPHENOL
  • PARA-PROPIONYLPHENOL
  • 4-HYDROXYPROPIOPHENONE / PAROXYPROPIONE
  • 1-(4-hydroxyphenyl)propan-1-one
  • 4''-HYDROXYPROPRIOPHENONE
  • 4′-Hydroxypropiophen
  • P-acetone
  • 4'-Hydroxypropiophenone, 97+%
  • 4'-Hydroxypropiophenone≥ 99.0% (HPLC)
  • P-HYDROXYPROPIOPHENONE
  • P-HYDROXYL PROPIOPHENONE
  • P-METHOXYACETOPHENONE
  • PAROXYPROPIONE
  • PARA METHOXY ACETOPHENONE
  • VANATONE
  • 1-(4-hydroxyphenyl)-1-propanon
  • 1-(4-Hydroxyphenyl)-1-propanone
  • 1-(p-Hydroxyphenyl)-1-Propanone
  • 4’-hydroxy-propiophenon
  • LABOTEST-BB LT00855519
  • LABOTEST-BB LT01595901
  • ETHYL 4-HYDROXYPHENYL KETONE
  • FEMA 2005
  • AURORA 5371
  • p-Methylbenzoic Acid Methyl Ether
  • ACETANISOLE
  • AKOS 90580
  • AKOS BBS-00003225
  • AKOS BBS-00003216
  • 4-METHOXYPHENYLETHANONE
  • 4-HYDROXYPHENYL ETHYL KETONE
  • 4'-HYDROXYPROPIOPHENONE
  • 4-HYDROXYPROPIOPHENONE
  • 4-ACETOANISOLE
  • 4-ACETYLANISOLE
  • (4-Hydroxyphenyl)-1-propanone
  • 4'-HYDROXY PROPIOPHENONE P-HYDROXYPHENYLETHYLKETONE
  • 4-HydoxyPropiophenone
  • 4'-Hydroxypropiophenone, 98+%
  • P-Hydroxyl
  • 1-Propanone, 1-(4-hydroxyphenyl)-
  • P-HYDROXYPHENYLETHYLKETONE
  • 1-(4-METHOXYPHENYL)ETHANONE
  • hydrolytic polyacrylamide
  • 4-Hydroxypropiophenon
  • 4-Propanoylphenol
  • 4-Propionylphenol
  • B 360
  • b360
  • Bio-Fren
  • Ethyl p-hydroxyphenyl ketone
  • ethylp-hydroxyphenylketone
  • Frenantol
  • Frenohypon
  • Frenon
  • Frenormon
  • H-365
  • Hydroxypropiophenone