ChemicalBook > CAS DataBase List > Melitracen hydrochloride
Melitracen hydrochloride
- Product Name
- Melitracen hydrochloride
- CAS No.
- 10563-70-9
- Chemical Name
- Melitracen hydrochloride
- Synonyms
- Adaptol;Thymeol;U-24973A;Melixeran;Trausabun;Adaptol-d6;Thymeol-d6;Melixeran-d6;Trausabun-d6;Melitracene-d6
- CBNumber
- CB8874744
- Molecular Formula
- C21H26ClN
- Formula Weight
- 327.89084
- MOL File
- 10563-70-9.mol
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Melitracen hydrochloride Property
- Melting point:
- 245-248°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to Off-White
- Water Solubility
- H2O: 2mg/mL, clear (warmed)
- CAS DataBase Reference
- 10563-70-9(CAS DataBase Reference)
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Safety
- Toxicity
- LD50 i.v. in mice: 52 mg/kg (Petersen)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- M215500
- Product name
- MelitracenHydrochloride
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
Usbiological
- Product number
- 015892
- Product name
- Melitracen-d6 Hydrochloride
- Packaging
- 1mg
- Price
- $446
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD71923
- Product name
- Melitracen hydrochloride
- Packaging
- 5G
- Price
- $450
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD71923
- Product name
- Melitracen hydrochloride
- Packaging
- 2g
- Price
- $250
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 18692
- Product name
- MelitracenHCl
- Packaging
- 5mg
- Price
- $950
- Updated
- 2021/12/16
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Melitracen hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Originator
Trausabun,Lusofarma,W. Germany,1965
Uses
Antidepressant
Definition
ChEBI: Melitracen hydrochloride is a member of anthracenes.
Manufacturing Process
24 g of 2-o-benzoylphenylpropanol-2 (MP 116°C) were dissolved in 250 ml of anhydrous ether and the resulting solution was added dropwise while stirring to a suspension of 0.22 mol of dimethylaminopropylmagnesium chloride in 100 ml of ether. The reaction mixture was refluxed for one hour on a steam bath, and water and dilute hydrochloric acid were added until the reaction was pH 4-5. The aqueous phase was separated and 60 ml of concentrated aqueous ammonia were added. The mixture was extracted with ether, and the ether phase was separated, dried and evaporated in a steam bath. The residue was dissolved in hot petroleum ether and the solution left standing to cool for some time, whereupon 4-dimethylamino-1-phenyl-1-[2-(2-hydroxy-2- propyl)phenyl]-butanol-1 crystallized out as white crystals which were sucked off. After drying they melted at 88°C to 90°C.
10 g of this compound were cautiously dissolved in 50 ml of concentrated
sulfuric acid under cooling and the mixture was kept at room temperature for
24 hours, whereupon the reaction mixture was poured into 200 g of finely
crushed ice, and concentrated aqueous ammonia was added to about pH 9,
whereupon the oil which separated out was extracted with ether. The ether
phase was separated, dried and the ether evaporated on a steam bath. The
residue was dissolved in 20 ml of acetone and the solution neutralized with a
solution of dry hydrogen chloride in ether. The white crystals of 9-γdimethylaminopropylidene-10,10-dimethyl-9,10-dihydroanthracene
hydrochloride which separated out was filtered off and dried. Yield 9 g. MP
245°C to 247°C.
Therapeutic Function
Antidepressant
Biological Activity
Melitracen is a tricyclic antidepressant (TCA) th at likely exerts its in vivo efficacy similarly as imipramine and amitriptyline by inhibiting serotonin-norepinephrine reuptake.
Melitracen hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Melitracen hydrochloride manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Melitracen hydrochloride 10563-70-9
- Price
- US $0.00-0.00/Kg/Bag
- Min. Order
- 100g
- Purity
- 99%min
- Supply Ability
- 1000G
- Release date
- 2021-07-02
Hebei Mujin Biotechnology Co.,Ltd
- Product
- Melitracen hydrochloride 10563-70-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19
Hebei Yanxi Chemical Co., Ltd.
- Product
- Melitracen hydrochloride 10563-70-9
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 0.99
- Supply Ability
- 50MT/month
- Release date
- 2024-04-26
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