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(R)-1-N-Boc-2-(hydroxymethyl)piperazine

Product Name
(R)-1-N-Boc-2-(hydroxymethyl)piperazine
CAS No.
169448-87-7
Chemical Name
(R)-1-N-Boc-2-(hydroxymethyl)piperazine
Synonyms
Nicotinamide Impurity 202;(R)-1-Boc-2-Hydroxymethyl-piperazine;(R)-1-Boc-2-(hyroxyMethyl)piperazine;(R)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE HCl;(S)-1-Boc-2-Hydroxymethyl-piperazine ,98%;(R)-1-Boc-2-Hydroxymethyl-piperazine ,98%;(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (R)-2-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (2R)-2-(hydroxymethyl)piperazin-1-carboxylate;tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate
CBNumber
CB8948025
Molecular Formula
C10H20N2O3
Formula Weight
216.28
MOL File
169448-87-7.mol
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(R)-1-N-Boc-2-(hydroxymethyl)piperazine Property

Boiling point:
324.0±17.0 °C(Predicted)
Density 
1.085±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
14.97±0.10(Predicted)
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-D0658
Product name
(R)-1-Boc-2-Hydroxymethyl-piperazine
Purity
≥97.0%
Packaging
250mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-D0658
Product name
(R)-1-Boc-2-Hydroxymethyl-piperazine
Purity
≥97.0%
Packaging
1g
Price
$87
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140933
Product name
(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate
Packaging
250mg
Price
$100
Updated
2021/12/16
Activate Scientific
Product number
AS3136
Product name
(R)-1-Boc-2-(Hydroxymethyl)piperazine
Purity
97+% ee
Packaging
1g
Price
$146
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140933
Product name
(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate
Packaging
500mg
Price
$160
Updated
2021/12/16
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(R)-1-N-Boc-2-(hydroxymethyl)piperazine Chemical Properties,Usage,Production

Uses

(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof.

Synthesis

Lithium aluminum hydride (1M in THF, 26 ml) was added to a solution of L-TERT- butyl 2-methyl (2R)-piperazine-1, 2-dicarboxylate (2. 55 g) in THF (70 ml) at-40°C, and then the reaction was warmed to room temperature. After stirring for 1 h, this reaction system was cooled to 0°C and quenched by sequential addition of water (1 ml), sodium hydroxide (2N, 1 ml), and then water (2 ml). The resulting slurry was filtered and concentrated in vacuo to give (R)-1-N-Boc-2-(hydroxymethyl)piperazine.

(R)-1-N-Boc-2-(hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-N-Boc-2-(hydroxymethyl)piperazine Suppliers

China 103 Europe 1 Germany 2 India 1 United Kingdom 3 United States 15 Global 125
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View Lastest Price from (R)-1-N-Boc-2-(hydroxymethyl)piperazine manufacturers

Career Henan Chemical Co
Product
(R)-1-N-Boc-2-(hydroxymethyl)piperazine 169448-87-7
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2019-12-26

169448-87-7, (R)-1-N-Boc-2-(hydroxymethyl)piperazineRelated Search:

3-(tert-Butoxycarbonylamino)cyclobutanecarboxylic acid 1-N-Boc-3-Azetidinecarboxylic acid (S)-4-Boc-Piperazine-3-carboxylic acid 1-Boc-3-(Aminomethyl)azetidine 1-Boc-3-(Amino)azetidine tert-butyl (R)-2-(2-bromophenyl)-1,4-oxazepane-4-carboxylate (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE tert-butyl (R)-2-(4-bromophenyl)-1,4-oxazepane-4-carboxylate tert-butyl (R)-2-((methylamino)methyl)morpholine-4-carboxylate tert-butyl (R)-2-(4-cyanophenyl)-1,4-oxazepane-4-carboxylate 1-N-BOC-2-N'-METHYL-AMINO PIPERIDINE tert-butyl (R)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate tert-butyl (R)-2-(aminomethyl)-4,4-difluoropiperidine-1-carboxylate tert-butyl (R)-2-(aminomethyl)-5-bromoindoline-1-carboxylate (S)-1-Boc-2-Hydroxymethyl-piperazine (R)-1-BOC-3-(Hydroxymethyl)piperazine (R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID (R)-N-Boc-piperazine-2-carboxylic acid methyl ester

  • (R)-1-Boc-2-Hydroxymethyl-piperazine
  • 1-Piperazinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)-
  • tert-butyl (R)-2-(hydroxymethyl)piperazine-1-carboxylate
  • (R)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE HCl
  • 2-Methyl-2-propanyl(2R)-2-(hydroxymethyl)-1-piperazinecarboxylate
  • (R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate
  • (R)-1-Boc-2-Hydroxymethyl-piperazine ,98%
  • (S)-1-Boc-2-Hydroxymethyl-piperazine ,98%
  • tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate
  • (R)-1-Boc-2-(hyroxyMethyl)piperazine
  • (R)-1-N-Boc-2-(hydroxymethyl)piperazine###(R)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • (2R)-2-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester
  • tert-Butyl (2R)-2-(hydroxymethyl)piperazin-1-carboxylate
  • Nicotinamide Impurity 202
  • 169448-87-7
  • 16944-87-7
  • 169448-87-8
  • Piperaizine