3-Fluoro-5-bromobenzyl bromide
- Product Name
- 3-Fluoro-5-bromobenzyl bromide
- CAS No.
- 216755-57-6
- Chemical Name
- 3-Fluoro-5-bromobenzyl bromide
- Synonyms
- 3-Fluoro-5-bromoben bromide;3-Fluoro-5-broMobenl broMide;5-bromo-3-fluorobenzyl bromide;3-Fluoro-5-bromobenzyl bromide;3-Bromo-5-fluorobenzylbromide,95%;3-Fluoride-5-Bromine Bromine Benzyl;1-Bromo-3-(bromomethyl)-5-fluorobenzene;Benzene, 1-bromo-3-(bromomethyl)-5-fluoro-;1-Bromo-3-(bromomethyl)-5-fluorobenzene, alpha,3-Dibromo-5-fluorotoluene
- CBNumber
- CB91139478
- Molecular Formula
- C7H5Br2F
- Formula Weight
- 267.92
- MOL File
- 216755-57-6.mol
3-Fluoro-5-bromobenzyl bromide Property
- Melting point:
- 47 °C
- Boiling point:
- 251℃
- Density
- 1.923
- Flash point:
- 106℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- Slightly soluble in water (2.9 g/L) (25°C).
- Sensitive
- Lachrymatory
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B5338
- Product name
- 3-Bromo-5-fluorobenzyl Bromide
- Packaging
- 5G
- Price
- $90
- Updated
- 2025/07/31
- Product number
- B5338
- Product name
- 3-Bromo-5-fluorobenzyl Bromide
- Packaging
- 25G
- Price
- $314
- Updated
- 2025/07/31
- Product number
- B961523
- Product name
- 3-Bromo-5-fluorobenzyl Bromide
- Packaging
- 10g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- PC9276
- Product name
- 3-Bromo-5-fluorobenzyl Bromide
- Purity
- 98%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 1700-B-80
- Product name
- 3-Bromo-5-fluorobenzyl Bromide
- Purity
- 98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
3-Fluoro-5-bromobenzyl bromide Chemical Properties,Usage,Production
Uses
3-Bromo-5-fluorobenzyl bromide is employed as a intermediate for pharmaceutical and chemical research.
Synthesis
216755-56-5
216755-57-6
General procedure for the synthesis of 3-fluoro-5-bromobenzyl bromide from (3-bromo-5-fluorophenyl)methanol: 3-bromo-5-fluorobenzyl alcohol (1.79 g, 8.39 mmol) and triphenylphosphine (3.65 g, 10.10 mmol) were dissolved in dichloromethane (45 mL), followed by addition of carbon tetrabromide (3.34 g, 10.10 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was treated with diethyl ether (50 mL) and stirred at room temperature to form a white slurry. The slurry was filtered through CeliteTM and the residue was washed with diethyl ether (2 x 50 mL). The filtrate and washings were combined and the crude product was obtained by vacuum evaporation. The crude product was purified by silica gel column chromatography using 2% ethyl acetate/hexane as eluent to afford 3-bromo-5-fluorobenzyl bromide (2.21 g, 98%). The structure of the product was confirmed by 1H NMR, 19F NMR and 13C NMR.1H NMR (400 MHz, CDCl3): δ 7.33 (s, 1H), 7.18 (ddd, JHF 8.2 Hz, JHH = 2.0,2.0 Hz, 1H), 7.05 (ddd, JHF = 9.0 Hz, JHH = 1.8,1.6 Hz. 1H), 4.38 (s, 2H); 19F NMR (377 MHz, CDCl3): δ -110.19 to -110.14 (m, 1F); 13C NMR (101 MHz, CDCl3): δ 162.67 (d, JCF = 252.1 Hz), 141.61 (d, JCF = 8.5 Hz), 128.17 ( d, JCF = 3.1 Hz), 122.94 (d, JCF = 10.0 Hz), 119.39 (d, JCF = 24.6 Hz), 115.34 (d, JCF = 22.3 Hz), 31.31 (d, JCF = 2.3 Hz).
References
[1] Patent: WO2016/54728, 2016, A1. Location in patent: Paragraph 00128
[2] Patent: WO2016/74068, 2016, A1. Location in patent: Paragraph 00122
[3] Patent: CN104447730, 2017, B. Location in patent: Paragraph 0149-0150
[4] Patent: US2007/249607, 2007, A1. Location in patent: Page/Page column 81
[5] Patent: US2002/49204, 2002, A1
3-Fluoro-5-bromobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
3-Fluoro-5-bromobenzyl bromide Suppliers
- Tel
- --
- Fax
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- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
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View Lastest Price from 3-Fluoro-5-bromobenzyl bromide manufacturers
- Product
- 3-Fluoro-5-bromobenzyl bromide 216755-57-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2020-01-16
- Product
- 3-Fluoro-5-bromobenzyl bromide 216755-57-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2023-06-09
- Product
- 3-Fluoro-5-bromobenzyl bromide 216755-57-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-31