ChemicalBook > CAS DataBase List > 4'-Hydroxy-3'-nitroacetophenone

4'-Hydroxy-3'-nitroacetophenone

Product Name
4'-Hydroxy-3'-nitroacetophenone
CAS No.
6322-56-1
Chemical Name
4'-Hydroxy-3'-nitroacetophenone
Synonyms
1-(4-hydroxy-3-nitrophenyl)ethan-1-one;NSC 32113;2-Nitro-4-acetylphenol;Formoterol Impurity 68;4-ACETYL-2-NITRO-PHENOL;Acetophenone Impurity 8;-Hydroxy-3-nitroacetophenone;4-HYDROXY-3-NITROACETOPHENONE;3-NITRO-4-HYDROXY ACETOPHENONE;3'-NITRO-4'-HYDROXYACETOPHENONE
CBNumber
CB9114043
Molecular Formula
C8H7NO4
Formula Weight
181.15
MOL File
6322-56-1.mol
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4'-Hydroxy-3'-nitroacetophenone Property

Melting point:
132-135 °C(lit.)
Boiling point:
314.24°C (rough estimate)
Density 
1.4283 (rough estimate)
refractive index 
1.5468 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Chloroform, Dichloromethane, DMSO, Ethyl Acetate
form 
powder to crystal
pka
5.18±0.14(Predicted)
color 
Light yellow to Amber to Dark green
BRN 
1959078
CAS DataBase Reference
6322-56-1(CAS DataBase Reference)
NIST Chemistry Reference
4-Hydroxy-3-nitroacetophenone(6322-56-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
330256
Product name
4′-Hydroxy-3′-nitroacetophenone
Purity
98%
Packaging
1g
Price
$42.9
Updated
2023/01/07
TCI Chemical
Product number
H0968
Product name
4'-Hydroxy-3'-nitroacetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$42
Updated
2025/07/31
TRC
Product number
H948610
Product name
4’-Hydroxy-3’-nitroacetophenone,>95%
Packaging
100mg
Price
$85
Updated
2021/12/16
TRC
Product number
H948610
Product name
4’-Hydroxy-3’-nitroacetophenone,>95%
Packaging
2g
Price
$800
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK117789
Product name
4'-Hydroxy-3'-nitroacetophenone
Purity
98%
Packaging
1g
Price
$26
Updated
2021/12/16
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4'-Hydroxy-3'-nitroacetophenone Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

4’-Hydroxy-3’-nitroacetophenone, >95% (cas# 6322-56-1) is a compound useful in organic synthesis.

Uses

4′-Hydroxy-3′-nitroacetophenone may be used in chemical synthesis.

Preparation

Preparation by nitration of 4-hydroxyacetophenone.

Synthesis

99-93-4

6322-56-1

The general procedure for the synthesis of 4'-hydroxy-3'-nitroacetophenone from p-hydroxyacetophenone was as follows: phenol (94 mg, 1 mmol) was dissolved in 3 mL of glacial acetic acid in a 50 mL test tube. Solid Y(NO3)3-6H2O (383 mg, 1 mmol) was then added and the reaction mixture was shaken continuously for 10 min at room temperature. The reaction process was monitored by thin layer chromatography (TLC) in petroleum ether with 10% ethyl acetate. After completion of the reaction, 30 mL of ice-cold water was added to the reaction mixture and allowed to stand for 15 min. The solid product was collected by filtration and washed with distilled water. The resulting solid product was used for analysis without further purification. The experimental methods for synthesizing compounds 2a-2e are detailed in Supporting Information.

References

[1] Synthetic Communications, 1997, vol. 27, # 19, p. 3301 - 3311
[2] Synlett, 2003, # 2, p. 191 - 194
[3] Synthetic Communications, 2008, vol. 38, # 19, p. 3366 - 3374
[4] Chinese Chemical Letters, 2011, vol. 22, # 7, p. 827 - 830
[5] Synthetic Communications, 1998, vol. 28, # 15, p. 2773 - 2781

4'-Hydroxy-3'-nitroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-Hydroxy-3'-nitroacetophenone Suppliers

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View Lastest Price from 4'-Hydroxy-3'-nitroacetophenone manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4'-Hydroxy-3'-nitroacetophenone 6322-56-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-28
Henan Fengda Chemical Co., Ltd
Product
4'-Hydroxy-3'-nitroacetophenone 6322-56-1
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Shaanxi Dideu Medichem Co. Ltd
Product
4'-Hydroxy-3'-nitroacetophenone 6322-56-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
100 tons
Release date
2020-01-10

6322-56-1, 4'-Hydroxy-3'-nitroacetophenoneRelated Search:

2'-Hydroxyacetophenone CHLOROPHOSPHONAZO III 2-Nitroacetophenone 4-Nitroacetophenone 2-Bromoacetophenone 2',4'-Dichloroacetophenone 3-Aminoacetophenone 3-Nitroacetophenone 4'-Bromoacetophenone Acetophenone 2-HYDROXYACETOPHENONE 4'-Hydroxyacetophenone NITROGEN DIOXIDE Tolcapone 4-METHOXY-3-NITROACETOPHENONE 4-HYDROXY-3-NITROBENZOPHENONE 2-HYDROXY-5-NITROACETOPHENONE,2'-HYDROXY-5'-NITROACETOPHENONE 5'-Chloro-2'-hydroxy-3'-nitroacetophenone

  • 1-(4-HYDROXY-3-NITRO-PHENYL)-ETHANONE
  • 4-HYDROXY-3-NITROACETOPHENONE
  • 4-ACETYL-2-NITRO-PHENOL
  • 3-NITRO-4-HYDROXY ACETOPHENONE
  • 3'-NITRO-4'-HYDROXYACETOPHENONE
  • 4'-Hydroxy-3'-Nitro Acetophenone 3'-Nitro-4'-Hydroxyacetophenone 4'-Hydroxy-3'-Nitroacetophenone
  • 4'-hydroxy-3'-nitroacetophenone,1-(4-hydroxy-3-nitrophenyl)ethanone
  • 1-(4-hydroxy-3-nitrophenyl)-1-ethanone
  • 1-(4-hydroxy-3-nitrophenyl)ethan-1-one
  • 2-Nitro-4-acetylphenol
  • NSC 32113
  • 4-hydroxy-3-nitrobenzeneethylketone
  • Ethanone, 1-(4-hydroxy-3-nitrophenyl)-
  • 4’-Hydroxy-3’-nitroacetophenone, &gt
  • -Hydroxy-3-nitroacetophenone
  • 4'-Hydroxy-3'-nitroacetophenone ISO 9001：2015 REACH
  • 4’-Hydroxy-3’-Nitroacetophenone 98%
  • Acetophenone Impurity 8
  • 4'-Hydroxy-3'-nitroacetophenone
  • Formoterol Impurity 68
  • 6322-56-1
  • 6322-51-9
  • C8H7NO4
  • HOC6H3NO2COCH3
  • Building Blocks
  • C7 to C8
  • Carbonyl Compounds
  • Organic Building Blocks
  • Ketones
  • Building Blocks
  • C7 to C8
  • Carbonyl Compounds
  • Aromatics
  • Aromatic Acetophenones & Derivatives (substituted)
  • C7 to C8
  • Carbonyl Compounds
  • Ketones
  • Chemical Synthesis
  • Organic Building Blocks