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2(3H)-Benzoxazolone,7-amino-(9CI)

Product Name
2(3H)-Benzoxazolone,7-amino-(9CI)
CAS No.
81282-60-2
Chemical Name
2(3H)-Benzoxazolone,7-amino-(9CI)
Synonyms
Pardoprunox Impurity 1;7-Amino-2-benzoxazolone;7-Amino-2-benzoxazolinone;7-Aminobenzoxazol-2(3H)-one;7-Amino-2-benzoxazolinone>7-Amino-2-hydroxybenzoxazole;2(3H)-Benzoxazolone, 7-amino-;7-Aminobenzo[d]oxazol-2(3H)-one;7-amino-3h-1,3-benzoxazol-2-one;7-Amino-1,3-benzoxazol-2(3H)-one
CBNumber
CB91281906
Molecular Formula
C7H6N2O2
Formula Weight
150.13
MOL File
81282-60-2.mol
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2(3H)-Benzoxazolone,7-amino-(9CI) Property

Density 
1.438±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
soluble in Acetone, Chloroform, Ethyl Acetate, Methanol
form 
powder to crystal
pka
9.06±0.70(Predicted)
color 
White to Yellow to Orange
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2806
Product name
7-Amino-2-benzoxazolinone
Purity
>95.0%(GC)(T)
Packaging
250mg
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
A2806
Product name
7-Amino-2-benzoxazolinone
Purity
>95.0%(GC)(T)
Packaging
1g
Price
$110
Updated
2025/07/31
TRC
Product number
A593750
Product name
7-Amino-2(3H)-benzoxazolone
Packaging
250mg
Price
$1100
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0070447
Product name
7-AMINOBENZO[D]OXAZOL-2(3H)-ONE
Purity
95.00%
Packaging
25MG
Price
$721.88
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
6357
Product name
7-Amino-2(3H)-benzoxazolone
Packaging
25mg
Price
$875
Updated
2021/12/16
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2(3H)-Benzoxazolone,7-amino-(9CI) Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

Intermediate for the preparation of bifeprunox mesylate

Synthesis

811810-67-0

81282-60-2

General procedure for the synthesis of 7-amino-2(3H)-benzoxazolone from 5-chloro-7-nitrobenzo[d]oxazol-2(3H)-one: Compound 6 (4 g, 18.56 mmol) was dissolved in a 4:1 MeOH/DMF solvent mixture (50 ml) and 10% Pd/C catalyst (500 mg) was added. The hydrogenation reaction was carried out at 60 psi hydrogen pressure overnight. The progress of the reaction was monitored by TLC (unfolding agent ratio ethyl acetate:petroleum ether = 3:7). After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under vacuum. The crude product was crystallized with ether to give 2.8 g of beige solid in 99% yield. The structure of the product was confirmed by 1HNMR (DMSO-d6, 200 MHz): δ5.31 (2H, bs, NH2), 6.26 (1H, dd, J = 7.6 Hz, J'= 1 Hz, Ar-H), 6.38 (1H, dd, J = 8.4 Hz, J'= 1.2 Hz, Ar-H), 6.80 (1H, t, J = 8 Hz, Ar-H), 11.32 (1H, bs, NH).

References

[1] Patent: EP2377850, 2011, A1. Location in patent: Page/Page column 22
[2] Patent: US2006/194812, 2006, A1. Location in patent: Page/Page column 6
[3] Patent: WO2005/16898, 2005, A2. Location in patent: Page/Page column 11
[4] Patent: US2006/40932, 2006, A1. Location in patent: Page/Page column 5
[5] Patent: US2010/119622, 2010, A1. Location in patent: Page/Page column 17

2(3H)-Benzoxazolone,7-amino-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2(3H)-Benzoxazolone,7-amino-(9CI) Suppliers

Americas 1 Canada 2 China 71 Europe 2 India 3 Japan 1 United Kingdom 2 United States 7 Global 89
Aladdin Scientific
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Alichem Inc.
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OChem Incorporation
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TCI America
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Alfa Chemistry
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Medical Isotopes
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View Lastest Price from 2(3H)-Benzoxazolone,7-amino-(9CI) manufacturers

Career Henan Chemical Co
Product
7-Amino-1,3-benzoxazol-2(3H)-one 81282-60-2
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

81282-60-2, 2(3H)-Benzoxazolone,7-amino-(9CI)Related Search:

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  • 7-Aminobenzo[d]oxazol-2(3H)-one
  • 7-Amino-2-benzoxazolinone&gt
  • 7-Aminobenzoxazol-2(3H)-one
  • Pardoprunox Impurity 1
  • 2(3H)-Benzoxazolone, 7-amino-
  • 7-amino-2,3-dihydro-1,3-benzoxazol-2-one
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  • 81282-60-2
  • Chemical Amines
  • Amines
  • Aromatics
  • Heterocycles
  • AMINEPRIMARY