ChemicalBook > CAS DataBase List > Estradiol benzoate

Estradiol benzoate

Product Name
Estradiol benzoate
CAS No.
50-50-0
Chemical Name
Estradiol benzoate
Synonyms
ODB;MEE;Oestradiol benzoate;EBZ;folone;17β-Estradiol benzoate;(17beta)-Estra-1,3,5(10)-triene-3,17-diol 3-benzoate;diogynb;ESTON-B;Diogyn B
CBNumber
CB9131644
Molecular Formula
C25H28O3
Formula Weight
376.5
MOL File
50-50-0.mol
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Estradiol benzoate Property

Melting point:
191-198 °C(lit.)
alpha 
D25 +58 to +63° (c = 2 in dioxane)
Boiling point:
465.03°C (rough estimate)
Density 
1.0493 (rough estimate)
refractive index 
1.5460 (estimate)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in methanol.
pka
15.06±0.40(Predicted)
form 
Solid
color 
White
Water Solubility 
0.4mg/L(25 ºC)
Merck 
3703
BRN 
3107526
CAS DataBase Reference
50-50-0(CAS DataBase Reference)
NIST Chemistry Reference
Estradiol benzoate(50-50-0)
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Safety

Hazard Codes 
T
Risk Statements 
60-61-40
Safety Statements 
53-22-36/37/39-45
WGK Germany 
3
RTECS 
KG4050000
F 
8
HS Code 
29372319
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E8515
Product name
β-Estradiol 3-benzoate
Purity
≥97%
Packaging
1g
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2858
Product name
Estradiol Benzoate
Purity
certified reference material, pharmaceutical secondary standard
Packaging
500MG
Price
$286
Updated
2024/03/01
Sigma-Aldrich
Product number
BP396
Product name
Estradiol benzoate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
50MG
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
1251000
Product name
Estradiol benzoate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
10006487
Product name
Estradiol Benzoate
Purity
≥98%
Packaging
500mg
Price
$32
Updated
2024/03/01
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Estradiol benzoate Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

antiacne, antineoplastic

Uses

Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the treatment of lesions produced by diminution of bodily production of estrogens.

Definition

ChEBI: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.

Clinical Use

Estradiol is a semisynthetic estrogen compound. Its effects will mimic that of estrogen in animals. The most common use in small animals has been to terminate pregnancy.
Estradiol benzoate also has been used to terminate pregnancy (5-10 mg/kg divided into two or three SQ injections). Estradiol cypionate formulation had high efficacy (95%), but it had serious adverse effects and is not recommended. Estradiol cypionate is longer acting and more potent than other estrogen formulations. Estradiol valerate injection (20 mg/mL) is also available for human medicine to treat hypoestrogenism.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human reproductive effects by intramuscular route: menstrual cycle changes and disorders. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.

Estradiol benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Estradiol benzoate Suppliers

Belgium 2 Brazil 2 Canada 2 China 323 Czech Republic 1 Europe 3 France 5 Germany 6 India 31 Japan 3 Slovakia 1 Spain 2 Switzerland 3 United Kingdom 8 United States 41 Uruguay 1 Venezuela 1 Global 435
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View Lastest Price from Estradiol benzoate manufacturers

Sinoway Industrial co., ltd.
Product
estradiol benzoate 50-50-0
Price
US $0.00-0.00/Kg/Bag
Min. Order
0.10000000149011612Kg/Bag
Purity
USP, GMP
Supply Ability
2tons
Release date
2024-06-27
Wuhan Haorong Biotechnology Co.,Ltd
Product
Estradiol benzoate 50-50-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2023-07-31
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Estradiol benzoate 50-50-0
Price
US $0.00/g/Bag
Min. Order
100g
Purity
97.0~103.0%; USP43
Supply Ability
800kg/month
Release date
2021-06-03

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