(-)-Gossypol
- Product Name
- (-)-Gossypol
- CAS No.
- 90141-22-3
- Chemical Name
- (-)-Gossypol
- Synonyms
- CS-619;C:C&B61;(R)-Gossypol;(-)-Gossypol;AT 101, >=98%;GOSSYPOL，AT101;(R)-(-)-Gossypol;GOSSYPOL 90141-22-3;(-)-Gossypol USP/EP/BP;DL-gossypol acetic acid
- CBNumber
- CB91437592
- Molecular Formula
- C30H30O8
- Formula Weight
- 518.55
- MOL File
- 90141-22-3.mol
(-)-Gossypol Property
- Melting point:
- 166-167℃
- alpha
- D28 -386 to -390° (c = 0.5 g/100 g soln in CHCl3)
- Boiling point:
- 707.9±55.0 °C(Predicted)
- Density
- 1.403
- storage temp.
- -20°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 7.15±0.50(Predicted)
- form
- powder
- color
- white to light brown
- optical activity
- [α]/D -350 to -365°, c = 0.3 (CDCl3)
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A790545
- Product name
- AT101
- Packaging
- 5mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- BP-25397
- Product name
- AT101
- Purity
- 98%
- Packaging
- 25mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- A3196
- Product name
- AT-101
- Packaging
- 10mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- BP-25397
- Product name
- AT101
- Purity
- 98%
- Packaging
- 50mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- A3196
- Product name
- AT-101
- Packaging
- 50mg
- Price
- $330
- Updated
- 2021/12/16
(-)-Gossypol Chemical Properties,Usage,Production
Description
AT-101 (90141-22-3) is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.
Uses
AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.
Biological Activity
R-(-)-enantiomer of gossypol (Gossypol). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo .
Biochem/physiol Actions
AT101 [R-(-)-enantiomer of gossypol] is an orally available and well-tolerated natural BH3-mimetic that activates Bax and also induces mitochondrial Smac release. AT101 has shown anti-tumor activity as a single agent and in combination with standard anticancer drugs in a variety of tumor models. AT101 induced apoptosis in chemoresistant ovarian cancer cells.
storage
Store at -20°C
References
1) Kline et al. (2008), R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells; Exp. Hematol., 36 568 2) Balakrishnan et al. (2009), AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance; Blood, 113 149
(-)-Gossypol Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-Gossypol Suppliers
View Lastest Price from (-)-Gossypol manufacturers
- Product
- (-)-Gossypol 90141-22-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- (-)-Gossypol 90141-22-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- (-)-Gossypol 90141-22-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100Tons min
- Release date
- 2021-06-11