ChemicalBook > CAS DataBase List > 2,4-Dichloropyridine-3-carboxylic acid

2,4-Dichloropyridine-3-carboxylic acid

Product Name
2,4-Dichloropyridine-3-carboxylic acid
CAS No.
262423-77-8
Chemical Name
2,4-Dichloropyridine-3-carboxylic acid
Synonyms
2,4-Dichloronicotinic acid;2,4-Dichloronicotinc Acid;2,4-DichloronicotinicAcid>2,4-DICHLORONICOTINIC ACID,98%;2,4- twochlorine nicotinic acid;2,4-Dichloropyridine-3-carboxylicaci;2,4-Dichloropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2,4-dichloro-;262423-77-8;2,4-Dichloropyridine-3-carboxylic acid, CAS 262423-77-8
CBNumber
CB91459491
Molecular Formula
C6H3Cl2NO2
Formula Weight
192
MOL File
262423-77-8.mol
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2,4-Dichloropyridine-3-carboxylic acid Property

Melting point:
166-167°
Boiling point:
325.2±37.0 °C(Predicted)
Density 
1.612±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
0.79±0.25(Predicted)
color 
White to Almost white
InChI
InChI=1S/C6H3Cl2NO2/c7-3-1-2-9-5(8)4(3)6(10)11/h1-2H,(H,10,11)
InChIKey
ZFGZNVSNOJPGDV-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(Cl)=C1C(O)=O
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
710830
Product name
2,4-Dichloropyridine-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$25
Updated
2023/01/07
TCI Chemical
Product number
D4901
Product name
2,4-Dichloronicotinic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
D4901
Product name
2,4-Dichloronicotinic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$95
Updated
2025/07/31
TRC
Product number
D437153
Product name
2,4-Dichloropyridine-3-carboxylic acid
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD142970
Product name
2,4-Dichloronicotinic acid
Packaging
25g
Price
$360
Updated
2021/12/16
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2,4-Dichloropyridine-3-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

2,4-Dichloropyridine-3-carboxylic Acid is useful for the preparation of prolyl hydroxylase inhibitors or erythropoietin inducing agents.

Synthesis

26452-80-2

124-38-9

262423-77-8

GENERAL STEPS: A THF solution (28.4 mL, 56.8 mmol) of 2M lithium diisopropylammonium (LDA) was slowly added to a tetrahydrofuran (THF, 70 mL) solution of 2,4-dichloropyridine (7 g, 47.3 mmol) at -78 °C, maintaining the temperature at -78 °C and stirring for 30 min. Upon completion of the reaction, the reaction mixture was quenched with excess dry ice, followed by warming to room temperature and continued stirring for 30 min. After neutralizing the reaction mixture with 1.5 N hydrochloric acid (HCl), it was diluted with ethyl acetate (100 mL) and washed sequentially with saturated brine (2 x 50 mL) and deionized water (100 mL). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford 2,4-dichloronicotinic acid (4.5 g, 23.44 mmol, 50% yield) as a brown solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.47 (d, 1H), 7.74 (d, 1H).

References

[1] Patent: WO2016/149393, 2016, A1. Location in patent: Paragraph 0426
[2] Patent: US2011/77267, 2011, A1. Location in patent: Page/Page column 27
[3] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 386 - 390
[5] Patent: WO2015/116060, 2015, A1. Location in patent: Page/Page column 92

2,4-Dichloropyridine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloropyridine-3-carboxylic acid Suppliers

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View Lastest Price from 2,4-Dichloropyridine-3-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2,4-Dichloropyridine-3-carboxylic acid 262423-77-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
PNP Biotech Co. Ltd
Product
2,4-Dichloronicotinic acid 262423-77-8
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-07-13
Dideu Industries Group Limited
Product
2,4-Dichloropyridine-3-carboxylic acid 262423-77-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26

262423-77-8, 2,4-Dichloropyridine-3-carboxylic acidRelated Search:

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  • 2,4-Dichloronicotinc Acid
  • 2,4-Dichloropyridine-3-carboxylic acid
  • 2,4-DICHLORONICOTINIC ACID,98%
  • 2,4-Dichloronicotinic acid
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  • 2,4- twochlorine nicotinic acid
  • 2,4-DichloronicotinicAcid&gt
  • 3-Pyridinecarboxylic acid, 2,4-dichloro-
  • 2,4-Dichloropyridine-3-carboxylicaci
  • 2,4-Dichloropyridine-3-carboxylic acid ISO 9001：2015 REACH
  • <font color="#ff0000">262423-77-8</font>
  • 2,4-Dichloropyridine-3-carboxylic acid, CAS 262423-77-8
  • 262423-77-8
  • Heterocyclic Compounds