Trigonelline hydrochloride

Product Name: Trigonelline hydrochloride
CAS No.: 6138-41-6
Chemical Name: Trigonelline hydrochloride
Synonyms: SKL600;Trigoneline HCl;TRIGONELLINE HCL;EINECS 228-119-5;TIMTEC-BB SBB000182;Trigonelline hydroch;Trigonelline chloride;Gynesine Hydrochloride;Fenugreek hydrochloride;Coffearine Hydrochloride
CBNumber: CB9168394
Molecular Formula: C7H8ClNO2
Formula Weight: 173.6
MOL File: 6138-41-6.mol

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Trigonelline hydrochloride Property

Melting point:: ~260 °C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: Methanol (Slightly), Water
form: Solid
color: White to Off-White
Merck: 14,9694
BRN: 3734169
Stability:: Hygroscopic
InChI: InChI=1S/C7H7NO2.ClH/c1-8-4-2-3-6(5-8)7(9)10;/h2-5H,1H3;1H
InChIKey: TZSYLWAXZMNUJB-UHFFFAOYSA-N
SMILES: C1=[N+](C)C=CC=C1C([O-])=O.[H]Cl
CAS DataBase Reference: 6138-41-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S414255
Product name: TRIGONELLINE HYDROCHLORIDE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL80548
Product name: Trigonelline chloride
Purity: phyproof? Reference Substance
Packaging: 25MG
Price: $292
Updated: 2025/07/31

Sigma-Aldrich

Product number: 61407
Product name: Trigonelline hydrochloride
Purity: analytical standard
Packaging: 100mg
Price: $114
Updated: 2025/07/31

Sigma-Aldrich

Product number: S414255
Product name: TRIGONELLINE HYDROCHLORIDE
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: T1429
Product name: Trigonelline Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $199
Updated: 2025/07/31

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Trigonelline hydrochloride Chemical Properties,Usage,Production

Description

Trigonelline hydrochloride (N-methylnicotinic acid betaine hydrochloride) is a betaine type pyrimidine alkaloid found in various seeds, including coffee beans. Trigonelline is synthesized from nicotinic acid in many plant species. It has been reported that trigonelline has diverse biological activities, such as hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities. (The product is for research purpose only.)

Chemical Properties

It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from fenugreek.

Uses

Trigonelline (chloride) is an alkaloid found in plants and coffee. Trigonelline is a product of niacin metabolism that is excreted in urine.

in vivo

Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats^[2].

target

Beta Amyloid

IC 50

HSV-1

References

Trigonelline: a plant alkaloid with therapeutic potential for diabetes and central nervous system disease (a review)
J. Zhou, L. Chan, S. Zhou, Curr. Med. Chem. 2012, 19, 3523.
A Review on Biosynthesis, Analytical Techniques, and Pharmacological Activities of Trigonelline as a Plant Alkaloid
N. Mohamadi, F. Sharififar, M. Pournamdari, M. Ansari, J. Dietary Suppl. 2018, 15, 207.

Trigonelline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Trigonelline hydrochloride Suppliers

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View Lastest Price from Trigonelline hydrochloride manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Trigonelline chloride 6138-41-6
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-21

Xi an Biohorlden Industry Trade Co Ltd

Product: Trigonelline hydrochloride 6138-41-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000 kg
Release date: 2025-04-18

Shanghai Standard Technology Co., Ltd.

Product: Trigonelline Hydrochloride 6138-41-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-23

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6138-41-6

C7H8NO2Cl

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