H-ALA-TYR-PRO-GLY-LYS-PHE-NH2

Product Name: H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
CAS No.: 352017-71-1
Chemical Name: H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
Synonyms: AY-NH;AY-NH2;PAR4-AP;AYPGKF-NH2;AYPGKFAMIDE;PAR-4 aMide, Mouse;PAR-4 AGONIST AMIDE;Allantoin Impurity 3;ALA-TYR-PRO-GLY-LYS-PHE-NH2;PAR-4 Agonist Peptide, amide
CBNumber: CB9174223
Molecular Formula: C34H48N8O7
Formula Weight: 680.79
MOL File: 352017-71-1.mol

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H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Property

Boiling point:: 1143.1±65.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: Soluble in H2O
form: solid
pka: 9.84±0.15(Predicted)
color: White to off-white
Water Solubility: Soluble in water

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J66921
Product name: Selective Protease-Activated Receptor 4 (PAR4) Agonist
Packaging: 1mg
Price: $65.9
Updated: 2023/06/20

Alfa Aesar

Product number: J66921
Product name: Selective Protease-Activated Receptor 4 (PAR4) Agonist
Packaging: 5mg
Price: $212
Updated: 2021/12/16

Tocris

Product number: 1487
Product name: AY-NH2
Packaging: 1
Price: $309
Updated: 2021/12/16

TRC

Product number: A795103
Product name: AY-NH2
Packaging: 1mg
Price: $280
Updated: 2021/12/16

Usbiological

Product number: 254695
Product name: AY-NH2
Packaging: 1mg
Price: $573
Updated: 2021/12/16

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H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Chemical Properties,Usage,Production

Uses

AY-NH2 is used in the synthetic preparation of PAR4 agonist peptides towards PAR4 receptor activation.

Biological Activity

ay-nh2 is a selective agonist of par4 with ec50 value of 11 μm [1].protease-activated receptor-4 (par4) is a member of pars and plays an important role in mediating cellular effects of thrombin through acting g-proteins i, 12/13 (rho and ras activation) and q (calcium signaling) [2].ay-nh2 is a potent par4 agonist and has a higher (~10 fold) activity than gypgkf-nh2. using rat platelet aggregation assay, it was shown that ay-nh2 had highly platelet aggregation ability than gy-nh2 and gf-nh2 [1]. when tested with platelet-rich plasma harvested from wild-type c57bl6 mice, ay-nh2 treatment exhibited highly agonist activity on par4 while had no effect on other pars [3].in male wistar rats model of paw oedema, i.pl. injection of ay-nh2 markedly reduced the nociceptive score in response to both noxious and non-noxious mechanical stimuli, thus inhibiting carrageenan-induced mechanical hyperalgesia and allodynia [4].

storage

Store at -20°C

References

[1]. hollenberg, m.d., et al., proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. br j pharmacol, 2004. 143(4): p. 443-54.
[2]. yu, g., et al., increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. plos one, 2015. 10(4): p. e0122678.
[3]. faruqi, t.r., et al., structure-function analysis of protease-activated receptor 4 tethered ligand peptides. determinants of specificity and utility in assays of receptor function. j biol chem, 2000. 275(26): p. 19728-34.
[4]. asfaha, s., et al., protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. br j pharmacol, 2007. 150(2): p. 176-85.

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Suppliers

China 64 Europe 1 Germany 2 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 12 Global 84

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View Lastest Price from H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 manufacturers

Career Henan Chemical Co

Product: H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 352017-71-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

Career Henan Chemical Co

Product: H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 352017-71-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

352017-71-1, H-ALA-TYR-PRO-GLY-LYS-PHE-NH2Related Search:

H-GLY-TYR-PRO-GLY-LYS-PHE-NH2 H-SER-LEU-ILE-GLY-ARG-LEU-OH H-GLY-TYR-PRO-GLY-GLN-VAL-OH PAR-4 (1-6) amide (human) H-SER-LEU-ILE-GLY-ARG-LEU-NH2 COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (HUMAN) VKGILS-NH2 COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (MOUSE) PROTEASE Thrombin H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT

PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE

PAR-4 AGONIST AMIDE

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2

AY-NH2

AYPGKFAMIDE

AYPGKF-NH2

(ALA1)-COAGULATION FACTOR II RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE)

(Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt

PAR-4 Agonist Peptide, amide (PAR-4-AP

AY-NH2;PAR4-AP;PROTEINASE-ACTIVATED RECEPTOR 4 ACTIVATING PEPTIDE

Proteinase-Activated Receptor 4 Activating Peptide

(2S)-N-[2-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide

PAR-4 Agonist Peptide, amide(2TFA)

AY-NH

(ALA1)-PROTEINASE ACTIVATED RECEPTOR 4 (1-6) AMIDE (MOUSE)

(ALA1)-PAR-4 (1-6) AMIDE (MOUSE)

(ALA1)-THROMBIN RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE)

ALA-TYR-PRO-GLY-LYS-PHE-NH2

Proteinase activated receptor 4 amide, mouse

AYPGKFaMide, (Ala1)-ThroMbin Receptor-Like 3 (1-6) aMide (Mouse), (Ala1)-Coagulation Factor II Receptor-Like 3 (1-6) aMide (Mouse), (Ala1)-Proteinase Activated Receptor 4 (1-6) aMide (Mouse)

PAR-4 aMide, Mouse

PAR4-AP

PAR-4 Agonist Peptide, amide

AYPGKF-NH2 Selective Protease-Activated Receptor 4 (PAR4) Agonist

Protease-Activated Receptor-4, PAR-4 Agonist, amide

L-Phenylalaninamide, L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-

Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt >=98% (HPLC), solid

352017-71-1/1228078-65-6（TFA）

(Ala?)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt

(Ala1)-PAR-4 (1-6)) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse

AY-NH2 trifluoroacetate salt

Allantoin Impurity 3

352017-71-1

Immunomodulators and Antibiotics

Immune Cell Signaling and Blood

Immune System Regulation

BioChemical

Cell Biology

Cell Signaling and Neuroscience

peptide

Peptide Receptors

Proteinase-activated receptor (PAR)