3-Hydroxy-2-methylbenzoic acid

Product Name: 3-Hydroxy-2-methylbenzoic acid
CAS No.: 603-80-5
Chemical Name: 3-Hydroxy-2-methylbenzoic acid
Synonyms: HMBA;NSC 73133;3,2-Cresotic Acid;Hydroxytoluicacid,98%;3-HYDROXY-2-TOLUIC ACID;3-HYDROXY-O-TOLUIC ACID;2-Methyl-3-Hydroxybenzoic;3-Hydroxy-2-methylbenzoicaci;2-Methyl-3-hydroxybenzoicacid;3-HYDROXY-2-METHYLBENZOIC ACID
CBNumber: CB9179596
Molecular Formula: C8H8O3
Formula Weight: 152.15
MOL File: 603-80-5.mol

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3-Hydroxy-2-methylbenzoic acid Property

Melting point:: 143-148°C
Boiling point:: 336.6±30.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.83±0.10(Predicted)
color: Light Yellow
BRN: 2613791
InChI: InChI=1S/C8H8O3/c1-5-6(8(10)11)3-2-4-7(5)9/h2-4,9H,1H3,(H,10,11)
InChIKey: RIERSGULWXEJKL-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC(O)=C1C
CAS DataBase Reference: 603-80-5(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 29182900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PH005167
Product name: 3-hydroxy-2-methylbenzoic acid
Purity: AldrichCPR
Packaging: 5mg
Price: $172
Updated: 2023/06/20

TCI Chemical

Product number: H0885
Product name: 3-Hydroxy-2-methylbenzoic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: H0885
Product name: 3-Hydroxy-2-methylbenzoic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: H0885
Product name: 3-Hydroxy-2-methylbenzoic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $117
Updated: 2025/07/31

Usbiological

Product number: 278679
Product name: 3-Hydroxy-2-methylbenzoic acid
Packaging: 5g
Price: $305
Updated: 2021/12/16

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3-Hydroxy-2-methylbenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Crystalline Solid

Uses

3-Hydroxy-2-methylbenzoic Acid (cas# 603-80-5) is a compound useful in organic synthesis.

Synthesis

52130-17-3

603-80-5

General procedure for the synthesis of 2-methyl-3-hydroxybenzoic acid from 3-amino-2-methylbenzoic acid: to 5 mL of water containing 0.65 mL of concentrated sulfuric acid, a cold (0°C) suspension of 0.54 g (3.3 mmol) of 2-methyl-3-aminobenzoic acid was added, followed by 0.25 g (3.6 mmol) of solid sodium nitrite. After about 15 minutes of reaction, the mixture was poured into 20 mL of warm water containing 4 mL of concentrated sulfuric acid. The reaction mixture was slowly heated to 90°C and gas was observed to escape. When gas release ceased, the solution was cooled to room temperature and extracted with ethyl acetate. The organic layers were combined, washed with 0.5 N hydrochloric acid, dried and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 5% dichloromethane solution in methanol) to give 350 mg of white solid (melting point: 137-138°C) in 69% yield.1H NMR (CDCl3) data: δ 8.18 (br.s, 1H), 7.42 (d, J = 7.7 Hz, 1H), 7.13 (t, J = 7.9 Hz, 1H) , 6.93 (d, J = 7.9 Hz, 1H), 2.46 (s, 3H). Elemental analysis (C8H8O3) results: calculated values: C, 63.15; H, 5.29; measured values: C, 63.32; H, 5.36.

References

[1] Patent: US6335/459, 2002, B1. Location in patent: Page column 29
[2] Patent: US6335459, 2002, B1. Location in patent: Page column 29
[3] Tetrahedron Letters, 2000, vol. 41, # 11, p. 1741 - 1745
[4] Patent: US5952343, 1999, A
[5] Patent: US5484926, 1996, A

3-Hydroxy-2-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Sodium nitrite 3-Amino-2-methylbenzoic acid Ethyl acetate Hydrochloric acid Dichloromethane Methanol Sulfuric acid

Preparation Products

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3-Hydroxy-2-methylbenzoic acid Suppliers

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View Lastest Price from 3-Hydroxy-2-methylbenzoic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Hydroxy-2-methylbenzoic acid 603-80-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-12

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Hydroxy-2-methylbenzoic acid 603-80-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Hebei Yanxi Chemical Co., Ltd.

Product: 3-Hydroxy-2-methylbenzoic acid 603-80-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.00%
Supply Ability: 20tons
Release date: 2023-09-12

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