BIS(4-HYDROXYCINNAMOYL)METHANE

Product Name: BIS(4-HYDROXYCINNAMOYL)METHANE
CAS No.: 33171-05-0
Chemical Name: BIS(4-HYDROXYCINNAMOYL)METHANE
Synonyms: BISDEMETHOXY CURCUMIN;CURCUMIN 3;Misdemeanour;Didemethoxycurcumin;BIS-DESMETHOXYCURCUMIN;DEMETHOXYCURCUMIN, BIS-;Bisdemethoxycurcumin(b);(E,E)-BisdeMethoxycurcuMin;Bisdemethoxycurcumin(BDMC);BIS(4-HYDROXYCINNAMOYL)METHANE
CBNumber: CB9180475
Molecular Formula: C19H16O4
Formula Weight: 308.33
MOL File: 33171-05-0.mol

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BIS(4-HYDROXYCINNAMOYL)METHANE Property

Melting point:: 221-223 ºC
Boiling point:: 551.3±45.0 °C(Predicted)
Density: 1.285
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 8.50±0.46(Predicted)
form: solid
color: Orange to Dark Orange
BRN: 3149384
Stability:: Light Sensitive
LogP: 3.155 (est)

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Safety

WGK Germany: 3
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B6938
Product name: Bisdemethoxycurcumin
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3434
Product name: Bisdesmethoxycurcumin
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50MG
Price: $222
Updated: 2024/03/01

Sigma-Aldrich

Product number: 90594
Product name: Bisdemethoxycurcumin
Purity: analytical standard
Packaging: 10mg
Price: $322
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1075305
Product name: Bisdesmethoxycurcumin
Purity: UnitedStatesPharmacopeia(USP)ReferenceStandard
Packaging: 30mg
Price: $394
Updated: 2024/03/01

Cayman Chemical

Product number: 10960
Product name: Bisdemethoxycurcumin
Packaging: 10mg
Price: $107
Updated: 2024/03/01

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BIS(4-HYDROXYCINNAMOYL)METHANE Chemical Properties,Usage,Production

Uses

Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflammatory as well as chemotherapeutic activit y. Bisdemethoxycurcumin acts as an inhibitor of human pancreatic α-amylase, a target for type-2 diabetes .

Uses

Bisdemethoxycurcumin has been used:

to test its inhibitory effect on cell cycle and mitochondrial function in gastric adenocarcinoma cells
to test it neuroprotective role against lead (Pb) induced toxicity in dopaminergic and noradrenergic systems of Meriones shawi
as a standard for calibration curve generation to quantify plasma curcuminoids using high-performance liquid chromatography-diode array detection (HPLC-DAD) and ultraviolet (UV)

Definition

ChEBI: Bisdemethoxycurcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups. It has a role as a metabolite and an EC 3.2.1.1 (alpha-amylase) inhibitor. It is a beta-diketone, a polyphenol, an enone and a diarylheptanoid. It is functionally related to a 4-coumaric acid.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.

BIS(4-HYDROXYCINNAMOYL)METHANE Preparation Products And Raw materials

Raw materials

Preparation Products

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BIS(4-HYDROXYCINNAMOYL)METHANE Suppliers

Canada 1 China 178 Germany 1 India 3 Japan 2 United Kingdom 1 United States 16 Global 202

MedChemexpress LLC

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View Lastest Price from BIS(4-HYDROXYCINNAMOYL)METHANE manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: BIS(4-HYDROXYCINNAMOYL)METHANE 33171-05-0
Price: US $55.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-26

BINBO BIOLOGICAL CO.,LTD

Product: Bisdemethoxycurcumin (BDMC) 33171-05-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-02

PNP Biotech Co. Ltd

Product: Bisdemethoxycurcumin 33171-05-0
Price: US $0.00/kg
Min. Order: 25kg
Purity: 6.04%
Supply Ability: Inquiry
Release date: 2022-10-25

33171-05-0, BIS(4-HYDROXYCINNAMOYL)METHANERelated Search:

4-Methoxybenzoic acid Octyl 4-methoxycinnamate 5"-MethoxyhexahydrocurcuMin DihydrocurcuMin FLLL31 ASC-J9 (3S,5S)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTANE-3,5-DIOL HEXAHYDROCURCUMIN Tetrahydrocurcumin DEMETHOXYCURCUMIN 1,4-HEXADIENE BIS(4-HYDROXYCINNAMOYL)METHANE,BIS-(PARA-HYDROXYCINNAMOYL)METHANE DEMETHOXYCURCUMIN Curcumin

(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione

PARAPARADIHYDROXYDICINNAMOYLMETHANE

(E,E)-BisdeMethoxycurcuMin

(E,E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione

CURCUMIN 3

DEMETHOXYCURCUMIN, BIS-

BISDEMETHOXY CURCUMIN

BIS-DESMETHOXYCURCUMIN

BIS(4-HYDROXYCINNAMOYL)METHANE

Bisdemethoxycurcumin, 98%, from Zingiber officinale Rosc.

Didemethoxycurcumin

1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (E,E)-

Bis(p-hydroxycinnamoyl)methane

Deleted CAS No: 22608-12-4, 85801-92-9, 91884-88-7, 104024-29-5

Bisdemethoxycurcumin(BDMC)

Bisdemethoxycurcumin(b)

1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-

BIS(4-HYDROXYCINNAMOYL)METHANE USP/EP/BP

Misdemeanour

(1E,6E)-Bis(demethoxy)curcumin

(E,E)-Curcumin III,Bisdemethoxycurcumin,inhibit,(E,E)-Didemethoxycurcumin,Inhibitor,Apoptosis,Autophagy,(E,E)-Bisdemethoxycurcumin

Bisdemethoxycurcumin/1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-

33171-05-0

34939-16-0

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