ChemicalBook > CAS DataBase List > 2,6-Dimethoxypyridine-3-boronic acid
2,6-Dimethoxypyridine-3-boronic acid
- Product Name
- 2,6-Dimethoxypyridine-3-boronic acid
- CAS No.
- 221006-70-8
- Chemical Name
- 2,6-Dimethoxypyridine-3-boronic acid
- Synonyms
- 3-Borono-2,6-dimethoxypyridine;2,6-Dimethoxypyridine-3-Boroni;2,6-DIMETHOXYPYRIDINE-3-BORONIC ACID;2,6-DIMETHOXY-3-PYRIDINEBORONIC ACID;2,6-DIMETHOXY-3-PYRIDYL BORONIC ACID;2,6-DIMETHOXYPYRIDINE-5-BORONIC ACID;2,6-DIMETHOXYL-5-PYRIDINEBORONIC ACID;(2,6-dimethoxypyridin-3-yl)boronicaci;(2,6-DIMETHOXYPYRIDIN-3-YL)BORONIC ACID;(2,6-dimethoxy-3-pyridinyl)boronic acid
- CBNumber
- CB9192391
- Molecular Formula
- C7H10BNO4
- Formula Weight
- 182.97
- MOL File
- 221006-70-8.mol
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2,6-Dimethoxypyridine-3-boronic acid Property
- Melting point:
- 128-130°C
- Boiling point:
- 341.2±52.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- form
- powder or crystals
- pka
- 7.28±0.58(Predicted)
- color
- White to Almost white
- BRN
- 9391039
- CAS DataBase Reference
- 221006-70-8(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36/38
- Safety Statements
- 26-36
- WGK Germany
- 2
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 706086
- Product name
- 2,6-Dimethoxy-3-pyridineboronic acid
- Packaging
- 250mg
- Price
- $51.8
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 706086
- Product name
- 2,6-Dimethoxy-3-pyridineboronic acid
- Packaging
- 1g
- Price
- $100
- Updated
- 2023/01/07
TCI Chemical
- Product number
- D4690
- Product name
- 2,6-Dimethoxypyridine-3-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $86
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D4690
- Product name
- 2,6-Dimethoxypyridine-3-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $297
- Updated
- 2025/07/31
TRC
- Product number
- D479238
- Product name
- 2,6-Dimethoxypyridine-3-boronicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
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2,6-Dimethoxypyridine-3-boronic acid Chemical Properties,Usage,Production
Uses
Reactant for:
- Preparation of benzopyranone derivatives as positive GABAA receptor modulators
- Preparation of pyrazine derivatives as orally active corticotropin releasing factor-1 receptor antagonists
- Microwave-enhanced synthesis of trisubstituted pyridazines
- Preparation of biaryl derivatives via palladium-catalyzed Suzuki-Miyaura cross-coupling reaction with aryl- or heteroaryl halides
- Preparation of 3-arylpyridines via palladium-P Phos catalyzed Suzuki cross coupling
Synthesis
6231-18-1
5419-55-6
221006-70-8
Under nitrogen protection, 2,6-dimethoxypyridine (10 g, 71.84 mmol) and N,N-diisopropylethylamine (0.50 mL, 3.59 mmol) were dissolved in dry tetrahydrofuran (200 mL), and cooled to -40°C. The solution of n-butyl lithium (43.10 mL, 86.21 mmol) was added to the solution. At this temperature, n-butyllithium solution (43.10 mL, 86.21 mmol) was added slowly and dropwise. The reaction solution was stirred at -40 °C for 5 min and then slowly warmed to 0 °C and continued to be stirred at this temperature for 3 hours. Subsequently, the reaction solution was cooled again to -40 °C and triisopropyl borate (24.87 mL, 107.76 mmol) was slowly added. After addition, the reaction mixture was brought to room temperature and stirred for 1 hour. Upon completion of the reaction, the reaction was terminated by the addition of water (50 mL), followed by concentration under reduced pressure to remove the organic solvent. To the residue was added 1 M sodium hydroxide solution (100 mL) and the aqueous phase was washed with ethyl acetate (2 x 100 mL). The aqueous phase was adjusted to pH 3 with hydrochloric acid and a solid was precipitated. The solid was collected by filtration and dried to give 2,6-dimethoxypyridine-3-boronic acid (8.10 g, 61% yield). The product was characterized by 1H NMR (DMSO-d6): δ 7.87 (1H, d, J = 7.9 Hz), 6.36 (1H, d, J = 7.9 Hz), 3.90 (3H, s), 3.87 (3H, s).
References
[1] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0111
2,6-Dimethoxypyridine-3-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dimethoxypyridine-3-boronic acid manufacturers
Career Henan Chemical Co
- Product
- 2,6-Dimethoxypyridine-3-boronic acid 221006-70-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-12
221006-70-8, 2,6-Dimethoxypyridine-3-boronic acidRelated Search:
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2,6-DIMETHOXYPYRIDINE-3-BORONIC ACID PINACOL ESTER,2,6-DIMETHOXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER
2,6-Dimethoxypyridine
2-Methoxy-5-pyridineboronic acid
2-Methoxypyridine-3-boronic acid
2-HYDROXY-6-METHOXYPYRIDINE
6-HYDROXY-3-PYRIDINEBORONIC ACID
2,6-Dimethoxypyridine-3-boronic acid