Alacepril

Product Name: Alacepril
CAS No.: 74258-86-9
Chemical Name: Alacepril
Synonyms: du1219;Alapri;cetapril;Cetapfil;ALACEPRIL;Alacepril API;(s)-l-phenylalanin;Alacepril USP/EP/BP;N-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH;1-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH
CBNumber: CB9198959
Molecular Formula: C20H26N2O5S
Formula Weight: 406.5
MOL File: 74258-86-9.mol

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Alacepril Property

Melting point:: 155-156°
alpha: D25 -81.3° (c = 1.02 in ethanol)
Boiling point:: 679.1±55.0 °C(Predicted)
Density: 1.281±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.56±0.10(Predicted)
form: Solid
color: White to off-white
CAS DataBase Reference: 74258-86-9(CAS DataBase Reference)

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Safety

Toxicity: LD50 in rats, mice (mg/kg): >5000, >5000 orally; >3000, >3000 s.c.; ~2000, ~3000 i.p. (Iida, pp 7033-40)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FA158541
Product name: Alacepril
Packaging: 10mg
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0001937
Product name: ALACEPRIL
Purity: 95.00%
Packaging: 1MG
Price: $152.25
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA158541
Product name: Alacepril
Packaging: 1mg
Price: $40
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0001937
Product name: ALACEPRIL
Purity: 95.00%
Packaging: 1G
Price: $1428
Updated: 2021/12/16

Arctom

Product number: AS566841
Product name: Alacepril
Purity: ≥95%
Packaging: 5mg
Price: $44
Updated: 2021/12/16

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Alacepril Chemical Properties,Usage,Production

Description

Alacepril is an angiotensin-converting enzyme (ACE) inhibitor useful in the treatment of essential and renal hypertension. Compared with captopril, alacepril is a weaker ACE inhibitor in vino, yet clinically it has a longer duration of action and appears to be more active due to an added component of norepinephrine antagonism.

Originator

Dainippon (Japan)

Definition

ChEBI: Alacepril is a thioacetate ester and a dipeptide. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor.

Manufacturing Process

N-Methylmorpholine (1.03 g) was added to a solution of 1-(D-3-acetylthio-2- methylpropanoyl)-L-proline (2.65 g) in dry tetrahydrofuran (50 ml). The resulting solution was stirred and cooled at -20° to -15°C. Phenyl chloroformate (1.61 g) was added, and after 5 min, a solution of Lphenylalanine t-butyl ester hydrochloride (2.4 g) and N-methylmorpholine (1.03 g) in dry tetrahydrofuran (30 ml) was added. The mixture was stirred at -20° to -15°C for 1 h and then at room temperature overnight.
After removal of insoluble materials by filtration, the filtrate was concentrated under reduced pressure and the residue was dissolved in chloroform.
The chloroform solution was washed successively with 1 N sodium hydroxide, water, 10% citric acid, and water, dried and concentrated under reduced pressure. The residue was chromatographed on silica gel with chloroformmethanol (99:1) to give 4.2 g the 1-(D-3-acetylthio-2-methylpropanoyl)-Lprolyl- L-phenylalanine tert-butyl ester.
1-(D-3-Acetylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanine tert-butyl ester (2.5 g) was dissolved in a mixture of anisole (18 ml) and trifluoroacetic acid (37 ml). The solution was allowed to stand at room temperature for 1 h and then concentrated to dryness under reduced pressure. The residue was crystallized from diethyl ether. The 1-(D-3-acetylthio-2-methylpropanoyl)-Lprolyl- L-phenylalanine was obtained (1.8 g), melting point 155°-156°C (recrystallization from ethanol/n-hexane).

brand name

Cetapril

Therapeutic Function

Antihypertensive

Alacepril Preparation Products And Raw materials

Raw materials

4-Methylmorpholine Anisole Trifluoroacetic acid Amyl acetate

Preparation Products

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Alacepril Suppliers

Canada 1 China 42 Europe 2 Germany 1 Japan 1 United Kingdom 7 United States 13 Global 67

LGM Pharma

Tel: 1-(800)-881-8210
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
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TargetMol Chemicals Inc.

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Alfa Chemistry

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3B Scientific Corporation

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Waterstone Technology, LLC

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2A PharmaChem USA

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HONEST JOY HOLDINGS LIMITED

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3B Scientific Corporation

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AK Scientific, Inc.

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APAC Pharmaceutical, LLC

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Beta Pharma, Inc.

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BOSCHE SCIENTIFIC, LLC

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View Lastest Price from Alacepril manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Alacepril 74258-86-9
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Month
Release date: 2022-11-23

Shijiazhuang Gantuo Biotechnology Co., Ltd

Product: Alacepril 74258-86-9
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000 Kilogram/Kilograms per Week
Release date: 2023-03-10

Shaanxi Dideu Medichem Co. Ltd

Product: Alacepril 74258-86-9
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

74258-86-9, AlaceprilRelated Search:

Enalapril Benazepril Irbesartan ALTRENOGEST PYRAZOPHOS Acetaminophen Pyrrolidine Glycine Levulinic acid AMINO ACIDS ACETAMINOPHENOL BP/USP (2-ISOBUTYRYLAMINO-ACETYLAMINO)-ACETIC ACID (S)-N-(1-(2-Methyl-1-oxo-3-((1-oxopropyl)thio)propyl)-L-prolyl)-L-phen ylalanine Alacepril

(s)-l-phenylalanin

1-(d-3-acetylthio-2-methylpropanoyl)-l-prolyl-l-phenylalanine

cetapril

du1219

ALACEPRIL

L-Phenylalanine, 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl-

L-Phenylalanine, N-[1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl]-, (S)-

2-[[1-(3-Acetylsulfanyl-2-methylpropanoyl)pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

(S)-N-[1-[3-(Aeetylthio)-2-methyl-1-oxopropyl]-L-prolyl]-L-phenylalanine

1-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH

N-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH

N-[1-[(S)-3-(Acetylthio)-2-methyl-1-oxopropyl]-L-prolyl]-L-phenylalanine

Alacepril API

Cetapfil

Alacepril USP/EP/BP

(S)-2-((S)-1-((S)-3-(Acetylthio)-2-methylpropanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanoic acid

antihypertensive effect,DU 1219,DU1219,Inhibitor,oral,long lasting,inhibit,Angiotensin-converting Enzyme (ACE),Alacepril

Alapri

74258-86-9

C2OH26N2O5S

C20H26N2O5S

Active Pharmaceutical Ingredients