2-Iodo-4-nitroanisole
- Product Name
- 2-Iodo-4-nitroanisole
- CAS No.
- 5399-03-1
- Chemical Name
- 2-Iodo-4-nitroanisole
- Synonyms
- 2-Iodo-4-nitroanisol;2-Iodo-4-ntiroanisole;2-IODO-4-NITROANISOLE;2-iodo-4-nitrobenzyl ether;3-Iodo-4-methoxynitrobenzene;1-Iodo-2-Methoxy-5-nitrobenzene;2-IODO-1-METHOXY-4-NITROBENZENE;Benzene, 2-iodo-1-methoxy-4-nitro-;1,2-diaza-4-azanidacyclopenta-2,5-diene;3-Iodo-4-Methoxynitrobenzene[2-Iodo-4-nitroanisole]
- CBNumber
- CB9199754
- Molecular Formula
- C7H6INO3
- Formula Weight
- 279.03
- MOL File
- 5399-03-1.mol
2-Iodo-4-nitroanisole Property
- Melting point:
- 96-98°C
- Boiling point:
- 343.3±27.0 °C(Predicted)
- Density
- 1.893±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C7H6INO3/c1-12-7-3-2-5(9(10)11)4-6(7)8/h2-4H,1H3
- InChIKey
- KBQBNJHOTNIGDD-UHFFFAOYSA-N
- SMILES
- C1(OC)=CC=C([N+]([O-])=O)C=C1I
- CAS DataBase Reference
- 5399-03-1(CAS DataBase Reference)
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S362816
- Product name
- 2-IODO-4-NITROANISOLE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- S362816
- Product name
- 2-IODO-4-NITROANISOLE
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $179
- Updated
- 2024/03/01
- Product number
- I737190
- Product name
- 2-Iodo-4-nitroanisole
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- I737190
- Product name
- 2-Iodo-4-nitroanisole
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- X8330
- Product name
- 2-Iodo-4-nitroanisole
- Packaging
- 25g
- Price
- $77
- Updated
- 2021/12/16
2-Iodo-4-nitroanisole Chemical Properties,Usage,Production
Uses
2-Iodo-4-nitroanisole is commonly used in organic synthesis, especially as a synthetic intermediate in the fields of medicine and chemical research.
Synthesis
99-59-2
5399-03-1
Step A. Synthesis of 2-iodo-1-methoxy-4-nitrobenzene 2-Methoxy-5-nitroaniline (10.0 g, 0.060 mol) was suspended in water (150 mL) and concentrated sulfuric acid (12 mL, 0.22 mol) was added slowly. The temperature of the reaction mixture was maintained below 5 °C under cooling in an ice-salt bath, and a solution of sodium nitrite (4.8 g, 0.070 mol) in water (40 mL) was added dropwise. Subsequently, potassium iodide (16.8 g, 0.101 mol) was added and the mixture was heated to 90 °C and kept for 1 hour. Upon completion of the reaction, it was cooled to 0 °C and deep red crystals were precipitated, which were filtered, washed with water and dried. Purification by silica gel column chromatography (eluent: ethyl acetate/hexane) afforded the target compound 2-iodo-1-methoxy-4-nitrobenzene (13.6 g, 75% yield). 1H NMR (300 MHz, DMSO-d6): δ 8.57 (s, 1H), 8.28 (d, 1H), 7.19 (d, 1H), 3.98 (s, 3H). LCMS (M + H)+: m/z = 280.1 (C7H7INO3).
References
[1] Canadian Journal of Chemistry, 2005, vol. 83, # 3, p. 213 - 219
[2] Patent: US2009/286778, 2009, A1. Location in patent: Page/Page column 79
[3] Chem. News J. Ind. Sci., 1901, vol. 83, p. 285
[4] Journal of the Chemical Society, 1901, vol. 79, p. 1076,1077
[5] P. Ch. S., p. 238
2-Iodo-4-nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Iodo-4-nitroanisole manufacturers
- Product
- 2-Iodo-1-methoxy-4-nitrobenzene 5399-03-1
- Price
- US $2.00-5.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons
- Release date
- 2025-07-10