4-Chloro-6-iodoquinazoline
- Product Name
- 4-Chloro-6-iodoquinazoline
- CAS No.
- 98556-31-1
- Chemical Name
- 4-Chloro-6-iodoquinazoline
- Synonyms
- oro-6-iodoquinazoL;4-Chloro-6-iodiquinazoline;6-Iodo-4-chloroquinazoline;4-CHLORO-6-IODOQUINAZOLINE;4-chloro-6-iodo-qulinazoline;Quinazoline, 4-chloro-6-iodo-;4-Chloro-6-iodoquinazoline 95+%;4-Chloro-6-iodoquinazoline USP/EP/BP;6 - iodine - 4 - chloroquine thiazole Moiety;4-Chloro-6-iodoquinazoline 6-Iodo-4-chloroquinazoline
- CBNumber
- CB9208456
- Molecular Formula
- C8H4ClIN2
- Formula Weight
- 290.49
- MOL File
- 98556-31-1.mol
4-Chloro-6-iodoquinazoline Property
- Melting point:
- 175.0 to 179.0 °C
- Boiling point:
- 363.2±22.0 °C(Predicted)
- Density
- 2.017±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- pka
- 0.15±0.30(Predicted)
- form
- Solid
- color
- Light Brown to Dark Grey
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C8H4ClIN2/c9-8-6-3-5(10)1-2-7(6)11-4-12-8/h1-4H
- InChIKey
- BDAIUOPDSRAOKI-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C(I)C=C2)=C(Cl)N=C1
- CAS DataBase Reference
- 98556-31-1(CAS DataBase Reference)
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C2775
- Product name
- 4-Chloro-6-iodoquinazoline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- C367295
- Product name
- 4-Chloro-6-iodoquinazoline
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FC32925
- Product name
- 4-Chloro-6-iodoquinazoline
- Packaging
- 1g
- Price
- $195.4
- Updated
- 2021/12/16
- Product number
- 44892
- Product name
- 4-Chloro-6-iodoquinazoline,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 25G
- Price
- $97.88
- Updated
- 2021/12/16
- Product number
- FC32925
- Product name
- 4-Chloro-6-iodoquinazoline
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
4-Chloro-6-iodoquinazoline Chemical Properties,Usage,Production
Chemical Properties
Dark Grey Solid
Uses
4-Chloro-6-iodoquinazoline is an intermediate in the synthesis of Lapatinib (L175800).
Synthesis
16064-08-7
98556-31-1
Step B: Synthesis of 4-chloro-6-iodoquinazoline. Anhydrous dimethylformamide (DMF, 3.20 ml) was added to a stirred solution of 1,2-dichloroethane (DCE, 10 ml) under nitrogen protection and subsequently cooled in an ice water bath. A solution of oxalyl chloride (5.2 ml, 60 mmol) in DCE (25 ml) was slowly added dropwise. Formation of white precipitate was observed during dropwise addition. After completion of dropwise addition, the ice water bath was removed and the reaction mixture was continued to be stirred at room temperature for 5 minutes. Under nitrogen atmosphere, 6-iodo-4(H)-quinazolinone (5.0 g, 18 mmol) was added in batches, followed immediately by heating the mixture to reflux. After maintaining the reflux reaction for 4.5 h, it was cooled to room temperature. The reaction mixture was poured into an excess of ice-water mixture (about 300 ml) and extracted with dichloromethane (DCM, about 500 ml). The aqueous layer was further extracted with DCM (2 x 50 ml). All organic extracts were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 5.2 g (99% yield) of 4-chloro-6-iodoquinazoline as a brown solid.
References
[1] Patent: US2005/101617, 2005, A1. Location in patent: Page/Page column 6
[2] Patent: WO2011/2523, 2011, A1. Location in patent: Page/Page column 43
[3] Patent: KR2017/15848, 2017, A. Location in patent: Paragraph 0067; 0071; 0072
[4] Patent: CN106317026, 2017, A. Location in patent: Paragraph 0075; 0076; 0077; 0078
[5] Patent: CN103772411, 2016, B. Location in patent: Paragraph 0017; 0027; 0028
4-Chloro-6-iodoquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-6-iodoquinazoline Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from 4-Chloro-6-iodoquinazoline manufacturers
- Product
- 6-Iodo-4-Chloroquinazoline 98556-31-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-16
- Product
- 4-Chloro-6-iodoquinazoline 98556-31-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
- Product
- 4-Chloro-6-iodoquinazoline 988556-31-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2020-10-28