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Tricaine methanesulfonate

Product Name
Tricaine methanesulfonate
CAS No.
886-86-2
Chemical Name
Tricaine methanesulfonate
Synonyms
MS-222;TRICAINE;ETHYL 3-AMINOBENZOATE METHANESULFONATE;MS-22;TS 222;TRICAIN;finquel;metacaine;MS-222, Tricaine;MS-22、MS-222、TRICAIN
CBNumber
CB9214426
Molecular Formula
C9H11NO2.CH4O3S
Formula Weight
261.3
MOL File
886-86-2.mol
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Tricaine methanesulfonate Property

Melting point:
146-149 °C(lit.)
Density 
1.3799 (rough estimate)
refractive index 
1.5060 (estimate)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
Fine Powder
color 
White to off-white
Merck 
14,9621
BRN 
3775022
CAS DataBase Reference
886-86-2(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 3-amino-, ethyl ester, methanesulfonate (886-86-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DG2455000
10
HS Code 
29224999
Toxicity
LC50 (96hr) in rainbow trout: 50.50 mg/l (McKim)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A5040
Product name
Ethyl 3-aminobenzoate methanesulfonate salt
Purity
analytical standard
Packaging
25g
Price
$121
Updated
2024/03/01
Sigma-Aldrich
Product number
A5040
Product name
Ethyl 3-aminobenzoate methanesulfonate salt
Purity
analytical standard
Packaging
100g
Price
$321
Updated
2024/03/01
TCI Chemical
Product number
T0941
Product name
Tricaine
Purity
>97.0%(HPLC)(N)
Packaging
25g
Price
$80
Updated
2024/03/01
Cayman Chemical
Product number
20660
Product name
Ethyl 3-Aminobenzoate (methanesulfonate)
Purity
≥98%
Packaging
10g
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
20660
Product name
Ethyl 3-Aminobenzoate (methanesulfonate)
Purity
≥98%
Packaging
25g
Price
$75
Updated
2024/03/01
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Tricaine methanesulfonate Chemical Properties,Usage,Production

Chemical Properties

WHITE TO OFF-WHITE FINE POWDER

Uses

A benzocaine isomer derivative.

Uses

The anesthetic of choice for amphibians is tricaine methanesulfonate (MS - 222, tricaine, FINQUEL, Argent Chemical Laboratories, Redmond, WA) (Wright 2001f ). It is a white crystalline powder that may be mixed with water to anesthetize fi sh and amphibians. Amphibians are immersed in a bath of tricaine methanesulfonate until anesthesia is achieved and then maintained in fresh water for the particular procedure to be performed. For longer procedures, the patient may be immersed in a 50% dilution of the original induction solution or intubated and maintained on isofl urane.

Uses

Ethyl 3-Aminobenzoate Methanesulfonate is used as anesthetic for broodfish such as rainbow trout and red pacu. Ethyl 3-Aminobenzoate Methanesulfonate also acts as the sodium channel blocker which reverses the degenerative effects of fipronil insecticide.

Definition

ChEBI: A methanesulfonate salt obtained by reaction of tricaine with one molar equivalent of methanesulfonic acid. Used as an anaesthetic for fish.

General Description

Ethyl 3-aminobenzoate methanesulfonate is mainly used as an anesthetic for fish. It is also used for the euthanasia of all fish species especially zebrafish, which is commonly used in research.

Biological Activity

ethyl 3-aminobenzoate can block the generation of action potentials via voltage-dependent na+-channels.sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. sodium channels are also of special importance for the history of physiology.

in vitro

the major mode of action for ethyl 3-aminobenzoate was found to be nervous system suppression whereby the entrance of sodium into the nerve was inhibited, therefore limiting nerve membrane excitability. in addition, the nerve inhibition was facilitated by the lipid solubility of ethyl 3-aminobenzoate, which allowed it to move easily into the cell membrane to bind with sodium channels [1].

in vivo

previous study evaluated the potency and dynamics of ethyl 3-aminobenzoate-induced effects on neuronal firing of sensory and motor nerves alongside a defined motor behavior in xenopus laevis tadpoles. electrophysiological recordings of extraocular motor discharge and nerve activity were measured before, during and after administration of drugs. results showed that ethyl 3-aminobenzoate and benzocaine, but not pancuronium could cause a dose-dependent, reversible blockade of extraocular motor and sensory nerve activity. such results indicated that ethyl 3-aminobenzoate was able to block the activity of both sensory and motor nerves compatible with the mechanistic action of effective anesthetics, suggesting that ethyl 3-aminobenzoate was effective as single-drug anesthetic for surgical interventions in anamniotes [2].

References

[1] k. m. carter, c. m. woodley and r. s. brown. a review of tricaine methanesulfonate for anesthesia of fish. rev. fish biol. fisheries 21, 51-59 (2011).
[2] c. ramlochansingh, f. branoner, b. p. chagnaud, et al. efficacy of tricaine methanesulfonate (ms-222) as an anesthetic agent for blocking sensory-motor responses in xenopus laevis tadpoles. plos one 9(7), e101606 (2014).

Tricaine methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tricaine methanesulfonate Suppliers

Hubei SVETO New Material Technology Co., Ltd
Tel
13277095679
Fax
027-65662438
Email
1375175909@qq.com
Country
China
ProdList
609
Advantage
58
Changzhou josenchem Pharmaceutical Chemical Material Co.,Ltd.
Tel
519-519-85286950 13338194135
Fax
0519-85286950
Email
info@josenchem.com
Country
China
ProdList
75
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.
Tel
0519-85195575 15861192208
Fax
85195585
Email
850305@sunkechem.com
Country
China
ProdList
77
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69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7508
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55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
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57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
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57
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View Lastest Price from Tricaine methanesulfonate manufacturers

Hebei Duling International Trade Co. LTD
Product
Tricaine Methanesulfonate 886-86-2
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2023-02-09
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tricaine methanesulfonate 886-86-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-02
Henan Aochuang Chemical Co.,Ltd.
Product
Tricaine methanesulfonate 886-86-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14

886-86-2, Tricaine methanesulfonateRelated Search:


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