2-Methoxyethyl chloride
Uses- Product Name
- 2-Methoxyethyl chloride
- CAS No.
- 627-42-9
- Chemical Name
- 2-Methoxyethyl chloride
- Synonyms
- 1-CHLORO-2-METHOXYETHANE;Ethane, 1-chloro-2-methoxy-;2-CHLOROETHYL METHYL ETHER;JACS-627-42-9;2-Methoxyethyl chlor;2-Methoxyethylchlorid;Chloro-2-methoxyethane;2-Chlorethylmethylether;2-METHOXYETHYL CHLORIDE;CHLOROETHYL METHYL ETHER
- CBNumber
- CB9219188
- Molecular Formula
- C3H7ClO
- Formula Weight
- 94.54
- MOL File
- 627-42-9.mol
2-Methoxyethyl chloride Property
- Melting point:
- -55 °C
- Boiling point:
- 89-90 °C (lit.)
- Density
- 1.035 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.408(lit.)
- Flash point:
- 59 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 80g/l
- form
- Liquid
- color
- Clear colorless to yellow
- Water Solubility
- 60 g/L (20 C)
- BRN
- 1731028
- Stability:
- Volatile
- InChIKey
- XTIGGAHUZJWQMD-UHFFFAOYSA-N
- CAS DataBase Reference
- 627-42-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Chloroethyl methyl ether(627-42-9)
- EPA Substance Registry System
- Ethane, 1-chloro-2-methoxy- (627-42-9)
Safety
- Hazard Codes
- F,Xn
- Risk Statements
- 11-20/21/22-22
- Safety Statements
- 36/37-23-16
- RIDADR
- UN 3271 3/PG 2
- WGK Germany
- 3
- F
- 9
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29091900
- Hazardous Substances Data
- 627-42-9(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 242349
- Product name
- 2-Chloroethyl methyl ether
- Purity
- 98%
- Packaging
- 5g
- Price
- $48.4
- Updated
- 2025/07/31
- Product number
- 242349
- Product name
- 2-Chloroethyl methyl ether
- Purity
- 98%
- Packaging
- 100g
- Price
- $161
- Updated
- 2025/07/31
- Product number
- C1173
- Product name
- 2-Chloroethyl Methyl Ether
- Purity
- >98.0%(GC)
- Packaging
- 25mL
- Price
- $35
- Updated
- 2025/07/31
- Product number
- C1173
- Product name
- 2-Chloroethyl Methyl Ether
- Purity
- >98.0%(GC)
- Packaging
- 100mL
- Price
- $85
- Updated
- 2025/07/31
- Product number
- C1173
- Product name
- 2-Chloroethyl Methyl Ether
- Purity
- >98.0%(GC)
- Packaging
- 500mL
- Price
- $215
- Updated
- 2025/07/31
2-Methoxyethyl chloride Chemical Properties,Usage,Production
Uses
2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly.
Chemical Properties
clear colorless to yellowish liquid
Uses
2-Chloroethyl methyl ether was used in the synthesis of acyclic nucleosides of thieno[2,3-d] pyrimidine derivatives.
Uses
2-Chloroethyl methyl ether (2-Methoxyethyl chloride) was used in the synthesis of acyclic nucleosides of thieno[2,3-d]pyrimidine derivatives.
Synthesis
77-78-1
107-07-3
627-42-9
To a round-bottomed flask equipped with a distillation apparatus, calcium carbonate (27.3 g, 273.2 mmol), dimethyl sulfate (23.5 mL, 248.4 mmol) and 2-chloroethanol (16.6 mL, 248.4 mmol) were added sequentially. The reaction mixture was heated to 120-130°C and the reaction was continued until distillation ceased (about overnight). After completion of the reaction, the distillate was diluted with ether and washed with 2N NaOH solution. The aqueous layer was again extracted with ether, and all ether layers were combined and dried with anhydrous magnesium sulfate (MgSO?). Finally, the target product 2-chloroethyl methyl ether (16) was obtained as a colorless liquid by conventional distillation (collection of fractions with a vapor temperature of 88-90°C). Yield: 10.2 g, 43% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1784 - 1788
[2] Journal of the American Chemical Society, 1924, vol. 46, p. 2530
[3] Journal of the American Chemical Society, 1924, vol. 46, p. 2530
2-Methoxyethyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methoxyethyl chloride manufacturers
- Product
- 1-Chloro-2-methoxyethane 627-42-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-08-21
- Product
- 1-Chloro-2-methoxyethane 627-42-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.01KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-20
- Product
- 1-Chloro-2-methoxyethane 627-42-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-25