ChemicalBook > CAS DataBase List > MMP-2/MMP-9 INHIBITOR IV

MMP-2/MMP-9 INHIBITOR IV

Product Name: MMP-2/MMP-9 INHIBITOR IV
CAS No.: 292605-14-2
Chemical Name: MMP-2/MMP-9 INHIBITOR IV
Synonyms: CS-860;SB-3CT;SB−SB-3CT (SB 3CT;SB-3CT, 10 mM in DMSO;MMP-2/MMP-9 INHIBITOR IV;MMP-2/MMP-9 INHIBITITOR IV;SB-3CT, MMP-2 and MMP-9 inhibitor;[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane;2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane
CBNumber: CB9223336
Molecular Formula: C15H14O3S2
Formula Weight: 306.4
MOL File: 292605-14-2.mol

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MMP-2/MMP-9 INHIBITOR IV Property

Melting point:: 92-96°C
Boiling point:: 501.4±46.0 °C(Predicted)
Density: 1.329±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >20mg/mL
form: powder
color: white to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S1326
Product name: SB?3CT
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $364
Updated: 2025/07/31

Sigma-Aldrich

Product number: 444274
Product name: MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem
Packaging: 500μg
Price: $189
Updated: 2025/07/31

TCI Chemical

Product number: B5630
Product name: SB-3CT
Packaging: 25MG
Price: $253
Updated: 2025/07/31

TCI Chemical

Product number: B5630
Product name: SB-3CT
Packaging: 100MG
Price: $787
Updated: 2025/07/31

Cayman Chemical

Product number: 16337
Product name: SB-3CT
Purity: ≥95%
Packaging: 500μg
Price: $37
Updated: 2024/03/01

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MMP-2/MMP-9 INHIBITOR IV Chemical Properties,Usage,Production

Uses

SB 3CT is a selective and potent gelatinase inhibitor which may be used for the treatment of brain metastasis.

Uses

SB?3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation.

Definition

ChEBI: 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane is an aromatic ether.

Biochem/physiol Actions

SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM).

in vivo

SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) inhibits intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice^[3].

Animal Model:	Five-week-old male C.B.-17.SCID mice^[3]
Dosage:	50 mg/kg
Administration:	IP; every other day; five weeks
Result:	Inhibited intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice.

IC 50

MMP-2: 13.9 nM (Ki); MMP-9: 600 nM (Ki)

storage

Store at -20°C

MMP-2/MMP-9 INHIBITOR IV Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MMP-2/MMP-9 INHIBITOR IV manufacturers

Career Henan Chemical Co

Product: 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane 292605-14-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

292605-14-2, MMP-2/MMP-9 INHIBITOR IVRelated Search:

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SB-3CT

MMP-2/MMP-9 INHIBITITOR IV

MMP-2/MMP-9 INHIBITOR IV

2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane

[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane

SB-3CT (This product is only available in Japan.)

CS-860

MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem

Thiirane, [[(4-phenoxyphenyl)sulfonyl]methyl]-

Thiirane, 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-

SB&minus

SB-3CT, MMP-2 and MMP-9 inhibitor

SB-3CT, 10 mM in DMSO

2-[(4-PHENOXYBENZENE SULFONYL)METHYL] THIIRANE, 98%min

SB-3CT (SB 3CT

292605-14-2

2922605-14-2

Inhibitors