ChemicalBook > CAS DataBase List > 2-Fluoro-5-nitroaniline

2-Fluoro-5-nitroaniline

Product Name
2-Fluoro-5-nitroaniline
CAS No.
369-36-8
Chemical Name
2-Fluoro-5-nitroaniline
Synonyms
2-Fluoro-5-nitrobenzenamine;uoro-5-nitroaniL;Fluoronitroaniline1;2-Fluoro-5-nitroanil;5-Nitro-2-fluoroaniline;2-FLUORO-5-NITROANILINE;6-fluoro-3-nitroaniline;Aniline, 2-fluoro-5-nitro-;2-Fluoro-5-nitroaniline98%;2-Fluoro-5-nitroaniline>
CBNumber
CB9226014
Molecular Formula
C6H5FN2O2
Formula Weight
156.11
MOL File
369-36-8.mol
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2-Fluoro-5-nitroaniline Property

Melting point:
97-100 °C (lit.)
Boiling point:
295.5±20.0 °C(Predicted)
Density 
1.3822 (estimate)
Flash point:
196 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Crystalline Powder
pka
1.13±0.10(Predicted)
color 
Ochre-yellow to light brown
Water Solubility 
Slightly soluble
BRN 
2803491
InChI
InChI=1S/C6H5FN2O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,8H2
InChIKey
KJVBJICWGQIMOZ-UHFFFAOYSA-N
SMILES
C1(N)=CC([N+]([O-])=O)=CC=C1F
CAS DataBase Reference
369-36-8(CAS DataBase Reference)
NIST Chemistry Reference
2-Fluoro-5-nitroaniline(369-36-8)
EPA Substance Registry System
Benzenamine, 2-fluoro-5-nitro- (369-36-8)
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38
Safety Statements 
16-26-36
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29214210
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
155853
Product name
2-Fluoro-5-nitroaniline
Purity
98%
Packaging
25g
Price
$42.1
Updated
2025/07/31
Sigma-Aldrich
Product number
155853
Product name
2-Fluoro-5-nitroaniline
Purity
98%
Packaging
100g
Price
$281
Updated
2023/06/20
TCI Chemical
Product number
F0267
Product name
2-Fluoro-5-nitroaniline
Purity
>99.0%(GC)
Packaging
25g
Price
$62
Updated
2025/07/31
TRC
Product number
F593505
Product name
2-Fluoro-5-nitroaniline
Packaging
2.5g
Price
$65
Updated
2021/12/16
TRC
Product number
F593505
Product name
2-Fluoro-5-nitroaniline
Packaging
1g
Price
$55
Updated
2021/12/16
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2-Fluoro-5-nitroaniline Chemical Properties,Usage,Production

Chemical Properties

ochre-yellow to light brown crystalline powder

Uses

It is employed as pharmaceutical intermediate.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 6141, 1990 DOI: 10.1016/S0040-4039(00)97008-4

Synthesis

70-34-8

369-36-8

The general procedure for the synthesis of 2-fluoro-5-nitroaniline from 2,4-dinitrofluorobenzene is as follows: 18.61 g (0.10 mol) of 2,4-dinitrofluorobenzene, 0.5 g of 5% palladium-carbon catalyst, 100 mL of glacial acetic acid, and 100 mL of anhydrous ethanol were added to a 500 mL Parr hydrogenation unit. The device was equipped with a thermocouple and a cooling jacket. During the reaction, the temperature of the reaction mixture was maintained at 20-25°C, the hydrogen pressure was maintained at 370 psi, and the reaction time was 2.5 hours. Upon completion of the reaction, the reaction mixture was poured into 400 mL of water. It was extracted twice with 200 mL of dichloromethane, the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting residue was filtered through a silica gel pad and eluted with dichloromethane. The eluate was concentrated again under reduced pressure and the residue was further purified by column chromatography using dichloromethane:heptane (80:20, v/v) as eluent. Finally, the solvent was evaporated under reduced pressure to give 2.75 g of 2-fluoro-5-nitroaniline in 17.6% yield.

References

[1] Patent: US5105012, 1992, A
[2] Recueil des Travaux Chimiques des Pays-Bas, 1916, vol. 35, p. 142
[3] Chem. Zentralbl., 1913, vol. 84, # II, p. 760
[4] Patent: US5105012, 1992, A
[5] Patent: US5105012, 1992, A

2-Fluoro-5-nitroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-5-nitroaniline Suppliers

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View Lastest Price from 2-Fluoro-5-nitroaniline manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Fluoro-5-nitroaniline 369-36-8
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-04
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Fluoro-5-nitroaniline 369-36-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Henan Aochuang Chemical Co.,Ltd.
Product
2-Fluoro-5-nitroaniline 369-36-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17

369-36-8, 2-Fluoro-5-nitroanilineRelated Search:

4-NITRODIAZOAMINOBENZENE 4'-Nitroacetanilide N-Methyl-4-nitroaniline 2-Nitroaniline 4-NITRO-2-SULFOANILINE 2-Fluoroaniline 2,4-Dinitrofluorobenzene FDNP-VAL-NH2 1,5-Difluoro-2,4-dinitrobenzene 2,4-DINITRO-5-FLUOROTOLUENE N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE 4-Nitroaniline Fluorine 2-FLUORO-5-NITROPHENYL ISOCYANATE (S)-2-(5-fluoro-2,4-dinitrophenylaMino)propanaMide 2,4-DINITRO-5-FLUOROANILINE 2-FLUORO-4-NITROANILINE 5-FLUORO-2-NITROANILINE

  • 1-Amino-2-fluoro-5-nitrobenzene
  • Aniline, 2-fluoro-5-nitro-
  • Benzenamine, 2-fluoro-5-nitro-
  • 2-FLUORO-5-NITROANILINE
  • F03860 2-Fluoro-5-nitroaniline
  • Fluoronitroaniline1
  • 2-Fluoro-5-nitroaniline 96%
  • 2-Fluoro-5-nitroaniline98%
  • 2-Fluoro-5-nitrobenzenamine
  • 5-Nitro-2-fluoroaniline
  • 2-Fluoro-5-nitroaniline, 98% 25GR
  • 2-Fluoro-5-nitroaniline, 98% 5GR
  • 2-Fluoro-5-nitroaniline, 97+%
  • 2-Fluoro-5-nitroanil
  • 3-Amino-4-fluoronitrobenzene
  • 6-fluoro-3-nitroaniline
  • 2-Fluoro-5-nitroaniline&gt
  • uoro-5-nitroaniL
  • 369-36-8 (2-FLUORO-5-NITROANILINE )
  • 2-Fluoro-5-nitroaniline ISO 9001：2015 REACH
  • 369-36-8
  • FC6H3NO2NH2
  • Building Blocks
  • Amines
  • C2 to C6
  • Nitrogen Compounds
  • Organic Building Blocks
  • Aniline series
  • Amines
  • C2 to C6
  • Nitrogen Compounds
  • Anilines, Aromatic Amines and Nitro Compounds
  • API intermediates