2-Fluoro-5-nitroaniline
- Product Name
- 2-Fluoro-5-nitroaniline
- CAS No.
- 369-36-8
- Chemical Name
- 2-Fluoro-5-nitroaniline
- Synonyms
- 2-Fluoro-5-nitrobenzenamine;uoro-5-nitroaniL;Fluoronitroaniline1;2-Fluoro-5-nitroanil;5-Nitro-2-fluoroaniline;2-FLUORO-5-NITROANILINE;6-fluoro-3-nitroaniline;Aniline, 2-fluoro-5-nitro-;2-Fluoro-5-nitroaniline98%;2-Fluoro-5-nitroaniline>
- CBNumber
- CB9226014
- Molecular Formula
- C6H5FN2O2
- Formula Weight
- 156.11
- MOL File
- 369-36-8.mol
2-Fluoro-5-nitroaniline Property
- Melting point:
- 97-100 °C (lit.)
- Boiling point:
- 295.5±20.0 °C(Predicted)
- Density
- 1.3822 (estimate)
- Flash point:
- 196 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Crystalline Powder
- pka
- 1.13±0.10(Predicted)
- color
- Ochre-yellow to light brown
- Water Solubility
- Slightly soluble
- BRN
- 2803491
- InChI
- InChI=1S/C6H5FN2O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,8H2
- InChIKey
- KJVBJICWGQIMOZ-UHFFFAOYSA-N
- SMILES
- C1(N)=CC([N+]([O-])=O)=CC=C1F
- CAS DataBase Reference
- 369-36-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Fluoro-5-nitroaniline(369-36-8)
- EPA Substance Registry System
- Benzenamine, 2-fluoro-5-nitro- (369-36-8)
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- UN 1325 4.1/PG 2
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29214210
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 155853
- Product name
- 2-Fluoro-5-nitroaniline
- Purity
- 98%
- Packaging
- 25g
- Price
- $42.1
- Updated
- 2025/07/31
- Product number
- 155853
- Product name
- 2-Fluoro-5-nitroaniline
- Purity
- 98%
- Packaging
- 100g
- Price
- $281
- Updated
- 2023/06/20
- Product number
- F0267
- Product name
- 2-Fluoro-5-nitroaniline
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $62
- Updated
- 2025/07/31
- Product number
- F593505
- Product name
- 2-Fluoro-5-nitroaniline
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F593505
- Product name
- 2-Fluoro-5-nitroaniline
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
2-Fluoro-5-nitroaniline Chemical Properties,Usage,Production
Chemical Properties
ochre-yellow to light brown crystalline powder
Uses
It is employed as pharmaceutical intermediate.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 6141, 1990 DOI: 10.1016/S0040-4039(00)97008-4
Synthesis
70-34-8
369-36-8
The general procedure for the synthesis of 2-fluoro-5-nitroaniline from 2,4-dinitrofluorobenzene is as follows: 18.61 g (0.10 mol) of 2,4-dinitrofluorobenzene, 0.5 g of 5% palladium-carbon catalyst, 100 mL of glacial acetic acid, and 100 mL of anhydrous ethanol were added to a 500 mL Parr hydrogenation unit. The device was equipped with a thermocouple and a cooling jacket. During the reaction, the temperature of the reaction mixture was maintained at 20-25°C, the hydrogen pressure was maintained at 370 psi, and the reaction time was 2.5 hours. Upon completion of the reaction, the reaction mixture was poured into 400 mL of water. It was extracted twice with 200 mL of dichloromethane, the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting residue was filtered through a silica gel pad and eluted with dichloromethane. The eluate was concentrated again under reduced pressure and the residue was further purified by column chromatography using dichloromethane:heptane (80:20, v/v) as eluent. Finally, the solvent was evaporated under reduced pressure to give 2.75 g of 2-fluoro-5-nitroaniline in 17.6% yield.
References
[1] Patent: US5105012, 1992, A
[2] Recueil des Travaux Chimiques des Pays-Bas, 1916, vol. 35, p. 142
[3] Chem. Zentralbl., 1913, vol. 84, # II, p. 760
[4] Patent: US5105012, 1992, A
[5] Patent: US5105012, 1992, A
2-Fluoro-5-nitroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-5-nitroaniline Suppliers
- Tel
- --
- Fax
- --
- info@cm-finechemicals.com
- Country
- Switzerland
- ProdList
- 1186
- Advantage
- 58
- Tel
- --
- Fax
- --
- nfo@matrix-fine-chemicals.com
- Country
- Switzerland
- ProdList
- 6968
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from 2-Fluoro-5-nitroaniline manufacturers
- Product
- 2-Fluoro-5-nitroaniline 369-36-8
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-04
- Product
- 2-Fluoro-5-nitroaniline 369-36-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- 2-Fluoro-5-nitroaniline 369-36-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17