(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

Product Name: (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER
CAS No.: 72657-23-9
Chemical Name: (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER
Synonyms: R-(-)-Roche Ester;(S)-Methyl 3-hydroxy-2-;(-)-Methyl 2-methylhydracrylate;METHYL D-(R)-3-HYDROXYISOBUTYRATE;(-)-methyl d-β-hydroxyisobutyrate;(R)-(-)-METHYL B-HYDROXYISOBUTYRATE;Methyle(R)-(-)-β-hydroxyisobutyrate;METHYL (R)-(-)-3-HYDROXYISOBUTYRATE;(-)-METHYL D-BETA-HYDROXYISOBUTYRATE;Methyl-D-(R)-beta-hydroxyisobutyrate
CBNumber: CB9226746
Molecular Formula: C5H10O3
Formula Weight: 118.13
MOL File: 72657-23-9.mol

More

Less

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Property

Boiling point:: 76-77 °C12 mm Hg(lit.)
Density: 1.066 g/mL at 25 °C(lit.)
refractive index: n20/D 1.425
Flash point:: 178 °F
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
pka: 14.40±0.10(Predicted)
form: Liquid
color: Clear colorless
optical activity: [α]19/D −26°, c = 4 in methanol
BRN: 3587507
InChI: InChI=1S/C5H10O3/c1-4(3-6)5(7)8-2/h4,6H,3H2,1-2H3/t4-/m1/s1
InChIKey: ATCCIZURPPEVIZ-SCSAIBSYSA-N
SMILES: C(OC)(=O)[C@H](C)CO
CAS DataBase Reference: 72657-23-9(CAS DataBase Reference)

More

Less

Safety

Risk Statements: 10
Safety Statements: 16
WGK Germany: 3
HS Code: 29181990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 270148
Product name: Methyl (R)-(?)-3-hydroxy-2-methylpropionate
Purity: 99%
Packaging: 1g
Price: $39.83
Updated: 2025/07/31

Sigma-Aldrich

Product number: 270148
Product name: Methyl (R)-(?)-3-hydroxy-2-methylpropionate
Purity: 99%
Packaging: 5g
Price: $144.44
Updated: 2025/07/31

TCI Chemical

Product number: H0703
Product name: Methyl (R)-(-)-3-Hydroxyisobutyrate
Purity: >99.0%(GC)
Packaging: 5g
Price: $141
Updated: 2025/07/31

TCI Chemical

Product number: H0703
Product name: Methyl (R)-(-)-3-Hydroxyisobutyrate
Purity: >99.0%(GC)
Packaging: 25g
Price: $470
Updated: 2025/07/31

TRC

Product number: H943558
Product name: (R)-3-HydroxyisobutyricAcidMethylEster
Packaging: 2g
Price: $65
Updated: 2021/12/16

More

Less

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Clear Colorless Oil

Uses

Chiral derivative of 3-Hydroxyisobutyrate.

Uses

The (R)- and (S)-isomers are bifunctional building blocks for the synthesis of a wide variety of optically active molecules.

Synthesis

15484-46-5

72657-23-9

GENERAL PROCEDURE: The general procedure for the synthesis of (-)-methyl-D-BETA-hydroxyisobutyrate from methyl 2-(hydroxymethyl)acrylate is as follows: the Ene-reductase activity assay needs to be carried out in anaerobic conditions (Coy Laboratory, Grass Lake, MI) at ambient temperature. Preparation of reaction stock solutions consisted of dissolving each substrate (see below for details) in 50 mM Tris-HCl buffer (pH 7.5) supplemented with 200 μM NADP+, 100 mM glucose, and glucose dehydrogenase (GDH) from Thermoplasma acidophilum (2 units were used for the IVTT reaction and 5 (2 units for the IVTT reaction and 5 units for the purified enzyme reaction). Individual substrate concentrations were selected to ensure that vmax conditions or maximum solubility were achieved. At these substrate concentrations, adjust reaction times to achieve 10-50% substrate conversion. For OYE activity assays in IVTT experiments, 20 μL of reaction stock solution was mixed with 2-10 μL of IVTT reaction mixture and the total assay volume was adjusted to 30 μL with 50 mM Tris-HCl (pH 7.5).For assays of purified OYE1 variants, the enzyme (final concentration: 250 nM) was added to 500 μL of reaction stock solution. The reaction process was quenched by removing a 30 μL aliquot from the assay solution and mixing it thoroughly with 30 μL of ethyl acetate containing 1 mM cyclohexanone (as internal standard). Organic phase samples were collected and analyzed by gas chromatography (GC) (see below for specific protocol). Enantiomeric/diastereoisomeric excesses were calculated by integrating the peak areas of the products and substrates. The relative conversion rate of each substrate was calculated by dividing the measured conversion rate of the OYE1 variant by the corresponding rate of wild-type OYE1.

References

[1] Advanced Synthesis and Catalysis, 2015, vol. 357, # 8, p. 1775 - 1786
[2] Tetrahedron Asymmetry, 2009, vol. 20, # 2, p. 210 - 213
[3] Angewandte Chemie - International Edition, 2009, vol. 48, # 12, p. 2162 - 2165
[4] Advanced Synthesis and Catalysis, 2008, vol. 350, # 16, p. 2533 - 2543
[5] Advanced Synthesis and Catalysis, 2010, vol. 352, # 14-15, p. 2663 - 2666

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Suppliers

Americas 1 Belgium 1 Canada 2 China 138 Europe 1 France 2 Germany 6 India 10 Japan 3 Poland 2 Slovakia 1 Spain 1 Switzerland 2 The Netherlands 1 United Kingdom 10 United States 44 Global 225

Biosynth Carbosynth

Tel: --
Fax: --
Email: ales@carbosynth.com
Country: United Kingdom
ProdList: 2598
Advantage: 58

Apollo Scientific Ltd

Tel: --
Fax: --
Email: ales@apo
Country: United Kingdom
ProdList: 4521
Advantage: 58

Fisher Scientific Uk Ltd.

Tel: --
Fax: --
Email: .international@thermofisher.com
Country: United Kingdom
ProdList: 2932
Advantage: 58

JOHNSON MATTHEY PHARMA SERVICES

Tel: --
Fax: --
Email: group.info@matthey.com
Country: United Kingdom
ProdList: 108
Advantage: 58

CMS Chemicals Limited

Tel: --
Fax: --
Email: cms.marketing@cms-chemicals.com
Country: United Kingdom
ProdList: 3708
Advantage: 60

Key Organics Ltd.

Tel: --
Fax: --
Email: enquiries@keyorganics.net
Country: United Kingdom
ProdList: 851
Advantage: 58

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

Tokyo Chemical Industry UK Ltd.

Tel: --
Fax: --
Email: sales@tci-uk.co.uk
Country: United Kingdom
ProdList: 1637
Advantage: 50

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

VWR International

Tel: --
Fax: --
Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

More

Less

View Lastest Price from (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER 72657-23-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-19

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester 72657-23-9
Price: US $6.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (R)-Roche ester 72657-23-9
Price: US $6.20/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

72657-23-9, (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTERRelated Search:

2,2-DIMETHYL-5-PHENYL-1,3-DIOXANE-4,6-DIONE Diethyl allylmalonate DIETHYL 2-(2-CYANOETHYL)MALONATE Diethyl 2-bromo-2-methylmalonate 2,2,5-Trimethyl-1,3-dioxane-4,6-dione Diethyl bis(hydroxymethyl)malonate Triethyl methanetricarboxylate TETRAETHYL 1,1,2,2-ETHANETETRACARBOXYLATE DIETHYL DIALLYLMALONATE Dimethyl diethylmalonate Diethyl 1,1-cyclopropanedicarboxylate Yohimbine TRIETHYL 1,1,2-ETHANETRICARBOXYLATE Diethyl phenylmalonate DIETHYL DIETHYLMALONATE DIETHYL TERT-BUTYLMALONATE METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE 2-Hydroxy-2-methylpropionic acid methyl ester

(R)-(-)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

(R)-(-)-METHYL B-HYDROXYISOBUTYRATE

(R)-(-)-METHYL 3-HYDROXY-2-METHYLPROPIONATE

[R]-[-]-METHYL 3-HYDROXY-2-METHYL-PROPIONATE

D(-)-BETA-HYDROXYISOBUTYRIC ACID METHYL ESTER

D-(R)-(-)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER

METHYL D-(R)-3-HYDROXYISOBUTYRATE

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ES

(R)-(-)-3-Hydroxyisobutyric Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic Acid Methyl Ester Methyl (R)-(-)-3-Hydroxy-2-methylpropionate

Methyl (R)-(-)-beta-hydroxyisobutyrate, 98%

(R)-(-)-METHYL 3-HYDROXY-2-METHYLPROPION

(R)-(-)-3-Hydroxy-2-Methylpropionic acid Methyl ester, ee: 98%

Methyl (R)-(-)-3-hydroxy-2-Methylpropionate 99%

(R)-(-)-Methyl 3-hydroxy-2-methylpropionate for synthesis

Methyle(R)-(-)-β-hydroxyisobutyrate

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester, 99%, ee: 98%

3-hydroxy-2-methyl-, methyl ester, (2R)-Propanoic acid

(R)-(-)-3-Hydroxy-3-Hyroxyisobutyrate

(-)-METHYL D-BETA-HYDROXYISOBUTYRATE

METHYL (R)-(-)-3-HYDROXY-2-METHYLPROPIONATE

METHYL (R)-3-HYDROXY-2-METHYLPROPIONATE

METHYL (R)-(-)-3-HYDROXYISOBUTYRATE

(R)-(-)-3-hydroxy-2-methylpropionic*acid methyl E

Propanoic acid, 3-hydroxy-2-methyl-, methyl ester, (2R)-

(-)-methyl d-β-hydroxyisobutyrate

Methyl (2R)-3-hydroxy-2-methyl-propanoate

Methyl-D-(R)-beta-hydroxyisobutyrate

METHYL (R)-(-)-3-HYDROXY-2-METHYL-PROPIO NATE, 99% (99% EE/GLC)

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC*ACID METHYL EST

(2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester

R-(-)-Roche Ester

(-)-Methyl D-β-hydroxyisobutyrate, (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester

Methyl (R)-3-hydroxy-2-methylpropionate, (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester

(-)-Methyl 2-methylhydracrylate

(2R)-2-Methyl-3-hydroxypropanoic acid methyl ester

(2R)-2-Methyl-3-hydroxypropionic acid methyl ester

(R)-2-Methyl-3-hydroxypropionic acid methyl ester

(R)-Methyl 3-hydroxy-2-Methylpropanoate

Methyl(R)-(-)-3-Hydroxyisobutyrate&gt

(S)-Methyl 3-hydroxy-2-

methyI (R)-3-hydroxy-2-methylpropanoate

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity

Methyl (R)-3-hydroxy-2-methylpropanoate

(-) - Methyl-D-BATA-hydroxyisobutyrate

(R)-(-)-3-HYDROXY-2-METHYLPRO-PIONIC ACIDMETHY ESTER

Methyl (<i>R</i>)-(?)-3-hydroxy-2-methylpropionate

72657-23-9

Building Blocks for Liquid Crystals

Chiral Building Blocks

Esters (Chiral)

Chiral Compounds (Building Blocks for Liquid Crystals)

Organic Building Blocks

Esters

Asymmetric Synthesis

Aliphatics

Chiral Reagents

Building Blocks for Liquid Crystals