1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid

Product Name: 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid
CAS No.: 10314-98-4
Chemical Name: 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid
Synonyms: Z-INP-OH;Z-NIP-OH;Z-PIC(4)-OH;Cbz-DL-Inp-OH;BUTTPARK 75\50-27;RARECHEM AL BE 0487;TIMTEC-BB SBB003079;Z-ISONIPECOTIC ACID;N-CBZ-ISONIPECOTIC ACID;1-Cbz-isonipecotic Acid
CBNumber: CB9228694
Molecular Formula: C14H17NO4
Formula Weight: 263.29
MOL File: 10314-98-4.mol

More

Less

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Property

Melting point:: 78 °C
Boiling point:: 443.9±45.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 4.55±0.20(Predicted)
color: White to Almost white
InChI: InChI=1S/C14H17NO4/c16-13(17)12-6-8-15(9-7-12)14(18)19-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H,16,17)
InChIKey: URTPNQRAHXRPMP-UHFFFAOYSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CCC(C(O)=O)CC1
CAS DataBase Reference: 10314-98-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36
Safety Statements: 26-36/37/39-37/39
HazardClass: IRRITANT
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: C2563
Product name: 1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: C2563
Product name: 1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $103
Updated: 2025/07/31

TCI Chemical

Product number: C2563
Product name: 1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $341
Updated: 2025/07/31

TRC

Product number: B130010
Product name: 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylicAcid
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 269535
Product name: N-Cbz-Piperidine-4-carboxylic acid
Packaging: 5g
Price: $438
Updated: 2021/12/16

More

Less

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Whtie powder

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 42, p. 147, 1994 DOI: 10.1248/cpb.42.147

Synthesis

498-94-2

501-53-1

10314-98-4

NaHCO3 (1.5 eq.) and Na2CO3 (1.5 eq.) were added to 4-piperidinecarboxylic acid (1.29 g, 10 mmol) in a mixed solvent of acetonitrile/water (2:3, 0.1 M) and the pH was adjusted to 10-11. The reaction mixture was cooled down to 0 °C and then benzyl chloroformate (1.42 mL, 1.7 g, 10 mmol) was slowly added dropwise. After the dropwise addition, the reaction solution was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction mixture was acidified to pH ~2-3 by dropwise addition of aqueous 1N HCl. Subsequently, acetonitrile was removed by evaporation under reduced pressure, and the aqueous phase was extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 1-(benzyloxycarbonyl)piperidine-4-carboxylic acid in quantitative yield, and the product was used directly in the next step of the reaction.

References

[1] Synlett, 2017, vol. 28, # 3, p. 376 - 380
[2] Tetrahedron, 1997, vol. 53, # 32, p. 10983 - 10992
[3] Patent: US2010/152158, 2010, A1. Location in patent: Page/Page column 31
[4] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 60
[5] Patent: US2010/222324, 2010, A1. Location in patent: Page/Page column 57

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Isonipecotic acid Benzyl chloroformate Sodium hydroxide

Preparation Products

More

Less

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Suppliers

Americas 1 Belgium 1 China 197 Europe 3 France 3 Germany 9 India 13 Japan 5 South Korea 1 Spain 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 15 United States 52 Global 305

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Molekula Limited

Tel: --
Fax: --
Email: o@molekula.com
Country: United Kingdom
ProdList: 6127
Advantage: 58

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Key Organics Limited/Bionet Research

Tel: --
Fax: --
Email: enquiries@keyorganics.ltd.uk
Country: United Kingdom
ProdList: 6663
Advantage: 50

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

Atlantic Research Chemicals Ltd.

Tel: --
Fax: --
Email: info@atlantic-chemicals.com
Country: United Kingdom
ProdList: 5618
Advantage: 63

ETA SCIENTIFIC Co.,Ltd

Tel: --
Fax: --
Email: sales@etascientific.com
Country: United Kingdom
ProdList: 6090
Advantage: 34

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United Kingdom
ProdList: 6401
Advantage: 74

Butt Park Ltd.

Tel: --
Fax: --
Email: 113707.50@compuserve.com
Country: United Kingdom
ProdList: 6078
Advantage: 30

Fulcrum Scientific Ltd.

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6565
Advantage: 38

More

Less

View Lastest Price from 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid manufacturers

Anhui Zhongda Biotechnology Co., Ltd

Product: 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 10314-98-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-10-24

Xingtai Haoxun Import and Export Trade Co., Ltd.

Product: 1-Cbz-piperidine-4-carboxylic Acid 10314-98-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2020-07-16

Jinan Ande Pharmaceutical Co.,Ltd.

Product: 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 10314-98-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100
Release date: 2021-12-23

10314-98-4, 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acidRelated Search:

CARBONYL SULFIDE PYRAZOPHOS Nequinate Trimethoprim Haloperidol 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 9-Phenyl-9H-carbazol-3-ylboronic acid 1-Cbz-4-Piperidone Ascoric Acid 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 1-N-Cbz-4-Methylpiperidine-4-carboxylic acid Diphenoxylate Carbonyl iron powder 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER 3-Boc-Amino-1-Cbz-piperidine-3-carboxylic acid 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-2-CARBOXYLIC ACID 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-3-CARBOXYLIC ACID 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-2-CARBOXYLIC ACID

1-[(BENZYLOXY)CARBONYL]-4-PIPERIDINECARBOXYLIC ACID

1-[(BENZYLOXY)CARBONYL]PIPERIDINE-4-CARBOXYLIC ACID

RARECHEM AL BE 0487

1-CBZ-4-PIPERIDINECARBOXYLIC ACID

1-Cbz-4-piperidinecarboxylic Acid 1-Carbobenzoxyisonipecotic Acid 1-Cbz-isonipecotic Acid

N - CBZ - 4 - piperidine forMic acid

PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER

N-CBZ-PIPERIDINE-4-CARBOXYLIC ACID

N-CBZ-ISONIPECOTIC ACID

N-CBZ-4-PIPERIDINECARBOXYLIC ACID

N-CARBOBENZOXY-HEXAHYDROISONICOTINIC ACID

N-CARBOBENZYLOXY-4-PIPERIDINECARBOXYLIC ACID

N-CARBOBENZOXY-PIPEREDINE-4-CARBOXYLIC ACID

N-BENZYLOXYCARBONYL-PIPERIDINE-4-CARBOXYLIC ACID

N-BENZYLOXYCARBONYL-ISONIPECOTIC ACID

Z-ISONICOT(HEXAHYDRO)-OH

Z-INP-OH

Z-PIC(4)-OH

TIMTEC-BB SBB003079

Cbz-DL-Inp-OH

Piperidine-4-carboxylic acid, N-CBZ protected

1-[(Benzyloxy)carbobyl]-3-piperidinecarbozylicacid

N-Cbz-Piperidine-4-Carboxylic

Piperidine-4-carboxylic acid, N-CBZ protected 97%

Piperidine-4-carboxylicacid,N-CBZprotected97%

Z-ISONIPECOTIC ACID

Z-NIP-OH

1-N-CBZ-PIPERIDINE-4-CARBOXYLIC ACID

1-CBZ-PIPERIDINE-4-CARBOXYLIC ACID

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid, 1-[(Benzyloxy)carbonyl]-4-carboxypiperidine

1-((benzyloxy)carbonyl)piperidin-4-carboxylic acid

1,4-Piperidinedicarboxylic acid, 1-(phenylMethyl) ester

1-Carbobenzoxy-4-piperidinecarboxylic Acid

BUTTPARK 75\50-27

1-Z-PIPERIDINE-4-CARBOXYLIC ACID

1-Carbobenzoxy-4-piperidinecarboxylic Acid &gt

1-Benzyloxycarbonylisonipecotic Acid

1-Carbobenzoxyisonipecotic Acid

1-Cbz-isonipecotic Acid

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid ISO 9001：2015 REACH

1-(Carbobenzoxy)piperidine-4-carboxylic acid

Z-Isonipecotic acid, 98%+

Z-Isonipecotic Acid extrapure, 99%

1-phenylmethoxycarbonylpiperidine-4-carboxylic acid

1-(Phenylmethyl) 1,4-piperidinedicarboxylate

Benzyl Benzoate Impurity 14

10314-98-4

78190-11-2

C14H16NO4

Carboxylic Acids

Pyrans, Piperidines & Piperazines

Carboxylic Acids

Pyrans, Piperidines &Piperazines

Piperidine

pharmacetical