ChemicalBook > CAS DataBase List > 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid

Product Name
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid
CAS No.
10314-98-4
Chemical Name
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid
Synonyms
Z-INP-OH;Z-NIP-OH;Z-PIC(4)-OH;Cbz-DL-Inp-OH;BUTTPARK 75\50-27;RARECHEM AL BE 0487;TIMTEC-BB SBB003079;Z-ISONIPECOTIC ACID;N-CBZ-ISONIPECOTIC ACID;1-Cbz-isonipecotic Acid
CBNumber
CB9228694
Molecular Formula
C14H17NO4
Formula Weight
263.29
MOL File
10314-98-4.mol
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1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Property

Melting point:
78 °C
Boiling point:
443.9±45.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
4.55±0.20(Predicted)
color 
White to Almost white
InChI
InChI=1S/C14H17NO4/c16-13(17)12-6-8-15(9-7-12)14(18)19-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H,16,17)
InChIKey
URTPNQRAHXRPMP-UHFFFAOYSA-N
SMILES
N1(C(OCC2=CC=CC=C2)=O)CCC(C(O)=O)CC1
CAS DataBase Reference
10314-98-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
26-36/37/39-37/39
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2563
Product name
1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
C2563
Product name
1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$103
Updated
2025/07/31
TCI Chemical
Product number
C2563
Product name
1-Carbobenzoxy-4-piperidinecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$341
Updated
2025/07/31
TRC
Product number
B130010
Product name
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylicAcid
Packaging
500mg
Price
$60
Updated
2021/12/16
Usbiological
Product number
269535
Product name
N-Cbz-Piperidine-4-carboxylic acid
Packaging
5g
Price
$438
Updated
2021/12/16
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1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Whtie powder

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 42, p. 147, 1994 DOI: 10.1248/cpb.42.147

Synthesis

498-94-2

501-53-1

10314-98-4

NaHCO3 (1.5 eq.) and Na2CO3 (1.5 eq.) were added to 4-piperidinecarboxylic acid (1.29 g, 10 mmol) in a mixed solvent of acetonitrile/water (2:3, 0.1 M) and the pH was adjusted to 10-11. The reaction mixture was cooled down to 0 °C and then benzyl chloroformate (1.42 mL, 1.7 g, 10 mmol) was slowly added dropwise. After the dropwise addition, the reaction solution was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction mixture was acidified to pH ~2-3 by dropwise addition of aqueous 1N HCl. Subsequently, acetonitrile was removed by evaporation under reduced pressure, and the aqueous phase was extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 1-(benzyloxycarbonyl)piperidine-4-carboxylic acid in quantitative yield, and the product was used directly in the next step of the reaction.

References

[1] Synlett, 2017, vol. 28, # 3, p. 376 - 380
[2] Tetrahedron, 1997, vol. 53, # 32, p. 10983 - 10992
[3] Patent: US2010/152158, 2010, A1. Location in patent: Page/Page column 31
[4] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 60
[5] Patent: US2010/222324, 2010, A1. Location in patent: Page/Page column 57

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Isonipecotic acid Benzyl chloroformate Sodium hydroxide

Preparation Products

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1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Suppliers

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View Lastest Price from 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid manufacturers

Anhui Zhongda Biotechnology Co., Ltd
Product
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 10314-98-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100tons
Release date
2023-10-24
Xingtai Haoxun Import and Export Trade Co., Ltd.
Product
1-Cbz-piperidine-4-carboxylic Acid 10314-98-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10tons
Release date
2020-07-16
Jinan Ande Pharmaceutical Co.,Ltd.
Product
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 10314-98-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100
Release date
2021-12-23

10314-98-4, 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acidRelated Search:

CARBONYL SULFIDE PYRAZOPHOS Nequinate Trimethoprim Haloperidol 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 9-Phenyl-9H-carbazol-3-ylboronic acid 1-Cbz-4-Piperidone Ascoric Acid 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 1-N-Cbz-4-Methylpiperidine-4-carboxylic acid Diphenoxylate Carbonyl iron powder 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER 3-Boc-Amino-1-Cbz-piperidine-3-carboxylic acid 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-2-CARBOXYLIC ACID 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-3-CARBOXYLIC ACID 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-2-CARBOXYLIC ACID

  • 1-[(BENZYLOXY)CARBONYL]-4-PIPERIDINECARBOXYLIC ACID
  • 1-[(BENZYLOXY)CARBONYL]PIPERIDINE-4-CARBOXYLIC ACID
  • RARECHEM AL BE 0487
  • 1-CBZ-4-PIPERIDINECARBOXYLIC ACID
  • 1-Cbz-4-piperidinecarboxylic Acid 1-Carbobenzoxyisonipecotic Acid 1-Cbz-isonipecotic Acid
  • N - CBZ - 4 - piperidine forMic acid
  • PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER
  • N-CBZ-PIPERIDINE-4-CARBOXYLIC ACID
  • N-CBZ-ISONIPECOTIC ACID
  • N-CBZ-4-PIPERIDINECARBOXYLIC ACID
  • N-CARBOBENZOXY-HEXAHYDROISONICOTINIC ACID
  • N-CARBOBENZYLOXY-4-PIPERIDINECARBOXYLIC ACID
  • N-CARBOBENZOXY-PIPEREDINE-4-CARBOXYLIC ACID
  • N-BENZYLOXYCARBONYL-PIPERIDINE-4-CARBOXYLIC ACID
  • N-BENZYLOXYCARBONYL-ISONIPECOTIC ACID
  • Z-ISONICOT(HEXAHYDRO)-OH
  • Z-INP-OH
  • Z-PIC(4)-OH
  • TIMTEC-BB SBB003079
  • Cbz-DL-Inp-OH
  • Piperidine-4-carboxylic acid, N-CBZ protected
  • 1-[(Benzyloxy)carbobyl]-3-piperidinecarbozylicacid
  • N-Cbz-Piperidine-4-Carboxylic
  • Piperidine-4-carboxylic acid, N-CBZ protected 97%
  • Piperidine-4-carboxylicacid,N-CBZprotected97%
  • Z-ISONIPECOTIC ACID
  • Z-NIP-OH
  • 1-N-CBZ-PIPERIDINE-4-CARBOXYLIC ACID
  • 1-CBZ-PIPERIDINE-4-CARBOXYLIC ACID
  • 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid, 1-[(Benzyloxy)carbonyl]-4-carboxypiperidine
  • 1-((benzyloxy)carbonyl)piperidin-4-carboxylic acid
  • 1,4-Piperidinedicarboxylic acid, 1-(phenylMethyl) ester
  • 1-Carbobenzoxy-4-piperidinecarboxylic Acid
  • BUTTPARK 75\50-27
  • 1-Z-PIPERIDINE-4-CARBOXYLIC ACID
  • 1-Carbobenzoxy-4-piperidinecarboxylic Acid &gt
  • 1-Benzyloxycarbonylisonipecotic Acid
  • 1-Carbobenzoxyisonipecotic Acid
  • 1-Cbz-isonipecotic Acid
  • 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid ISO 9001：2015 REACH
  • 1-(Carbobenzoxy)piperidine-4-carboxylic acid
  • Z-Isonipecotic acid, 98%+
  • Z-Isonipecotic Acid extrapure, 99%
  • 1-phenylmethoxycarbonylpiperidine-4-carboxylic acid
  • 1-(Phenylmethyl) 1,4-piperidinedicarboxylate
  • Benzyl Benzoate Impurity 14
  • 10314-98-4
  • 78190-11-2
  • C14H16NO4
  • Carboxylic Acids
  • Pyrans, Piperidines & Piperazines
  • Carboxylic Acids
  • Pyrans, Piperidines &Piperazines
  • Piperidine
  • pharmacetical