Ethyl diazoacetate
Synthesis- Product Name
- Ethyl diazoacetate
- CAS No.
- 623-73-4
- Chemical Name
- Ethyl diazoacetate
- Synonyms
- Ethyl 2-diazoacetate;Daae;Diazoacetic ester;Ethyl diazoate;diazoaceticester;diazoacetate soL;ETHYL DIAZOACETATE;Ethyl diazoethanoate;Ethylene Diazo Acetate;Diazoacetic acid ethyl
- CBNumber
- CB9241343
- Molecular Formula
- C4H6N2O2
- Formula Weight
- 114.1
- MOL File
- 623-73-4.mol
Ethyl diazoacetate Property
- Melting point:
- -22 °C (lit.)
- Boiling point:
- 140-141 °C/720 mmHg (lit.)
- Density
- 1.085 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.46(lit.)
- Flash point:
- 115 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Soluble), Hexane (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Light Yellow to Orange
- Merck
- 13,3021
- BRN
- 107654
- NIST Chemistry Reference
- Ethyl diazoacetate(623-73-4)
Safety
- Hazard Codes
- Xn,F
- Risk Statements
- 5-10-22-40-67-65-48/20-38-11-63
- Safety Statements
- 36/37-62-16
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- RTECS
- AG5775000
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29270000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H242Heating may cause a fire
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H351Suspected of causing cancer
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- E22201
- Product name
- Ethyl diazoacetate
- Purity
- contains ≥13 wt. % dichloromethane
- Packaging
- 5g
- Price
- $34.3
- Updated
- 2024/03/01
- Product number
- E22201
- Product name
- Ethyl diazoacetate
- Purity
- contains ≥13 wt. % dichloromethane
- Packaging
- 1kg
- Price
- $1730
- Updated
- 2024/03/01
- Product number
- 752150
- Product name
- Ethyl diazoacetate solution
- Purity
- 15% in toluene
- Packaging
- 25ML
- Price
- $28.4
- Updated
- 2024/03/01
- Product number
- 752150
- Product name
- Ethyl diazoacetate solution
- Purity
- 15% in toluene
- Packaging
- 100ML
- Price
- $73.6
- Updated
- 2024/03/01
- Product number
- E22201
- Product name
- Ethyl diazoacetate
- Purity
- contains ≥13 wt. % dichloromethane
- Packaging
- 20g
- Price
- $101
- Updated
- 2024/03/01
Ethyl diazoacetate Chemical Properties,Usage,Production
Synthesis
Glycine ethyl ester hydrochloride can be dissolved in a buffer solution composed of acetic acid and sodium acetate, and then dichloroethane is added as a solvent, and sodium nitrite solution is added dropwise at 10 to 15 ° C. After the dropwise addition, continue stirring for 15min. The separated organic layer is a dichloroethane solution of ethyl diazoacetate.
NH2CH2COOC2H5·HCl+NaNO2+HCl→N2CHCOOC2H5+NaCl+H2O
Chemical Properties
Liquid.
Uses
Reagent for ruthenium-catalyzed asymmetric cyclopropanation of alkenes.1
Uses
Hazard
Flammable liquid that explodes when heated.
Safety Profile
Poison by ingestion and intravenous routes. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Can explode. Explodes on contact with tris(dimethy1amino) antimony. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.
Purification Methods
It is a very volatile yellow oil with a strong pungent odour. EXPLOSIVE [distillation even under reduced pressure is dangerous and may result in an explosion — TAKE ALL THE NECESSARY PRECAUTIONS IF DISTILLATION IS TO BE CARRIED OUT]. It explodes in contact with conc H2SO4-trace acid causes rapid decomposition. It is slightly soluble in H2O, but is miscible with EtOH, *C6H6, pet ether and Et2O. To purify, dissolve it in Et2O [using CH2Cl2 instead of Et2O, protects the ester from acid], wash it with 10% aqueous Na2CO3, dry (MgSO4), filter and repeat as many times as possible until the Et2O layer loses its yellow colour, then remove the solvent below 20o (vacuum). Note that prolonged heating may lead to rapid decomposition and low yields. It can also be purified by steam distillation under reduced pressure but with considerable loss in yield. Place the residual oil in a brown bottle, keep below 10o, and use as soon as possible without distilling. For preparing esters usually the ethereal solution is used directly without purification. [Womack & Nelson Org Synth Coll Vol III 392 1955, UV: Miller & White J Am Chem Soc 79 5974 1957, Fieser 1 367 1967, Beilstein 3 IV 1495.]
Ethyl diazoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl diazoacetate manufacturers
- Product
- Ethyl diazoacetate 623-73-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- Ethyl diazoacetate 623-73-4
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-08-05