Ethyl diazoacetate

Synthesis

Product Name: Ethyl diazoacetate
CAS No.: 623-73-4
Chemical Name: Ethyl diazoacetate
Synonyms: Ethyl 2-diazoacetate;Daae;Diazoacetic ester;Ethyl diazoate;diazoaceticester;diazoacetate soL;ETHYL DIAZOACETATE;Ethyl diazoethanoate;Ethylene Diazo Acetate;Diazoacetic acid ethyl
CBNumber: CB9241343
Molecular Formula: C4H6N2O2
Formula Weight: 114.1
MOL File: 623-73-4.mol

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Ethyl diazoacetate Property

Melting point:: -22 °C (lit.)
Boiling point:: 140-141 °C/720 mmHg (lit.)
Density: 1.085 g/mL at 25 °C (lit.)
refractive index: n20/D 1.46(lit.)
Flash point:: 115 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Soluble), Hexane (Slightly), Methanol (Slightly)
form: Oil
color: Light Yellow to Orange
Merck: 13,3021
BRN: 107654
NIST Chemistry Reference: Ethyl diazoacetate(623-73-4)

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Safety

Hazard Codes: Xn,F
Risk Statements: 5-10-22-40-67-65-48/20-38-11-63
Safety Statements: 36/37-62-16
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
RTECS: AG5775000
HazardClass: 3.2
PackingGroup: III
HS Code: 29270000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H242Heating may cause a fire

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E22201
Product name: Ethyl diazoacetate
Purity: contains ≥13 wt. % dichloromethane
Packaging: 5g
Price: $34.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: E22201
Product name: Ethyl diazoacetate
Purity: contains ≥13 wt. % dichloromethane
Packaging: 1kg
Price: $1730
Updated: 2024/03/01

Sigma-Aldrich

Product number: 752150
Product name: Ethyl diazoacetate solution
Purity: 15% in toluene
Packaging: 25ML
Price: $28.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 752150
Product name: Ethyl diazoacetate solution
Purity: 15% in toluene
Packaging: 100ML
Price: $73.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: E22201
Product name: Ethyl diazoacetate
Purity: contains ≥13 wt. % dichloromethane
Packaging: 20g
Price: $101
Updated: 2024/03/01

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Ethyl diazoacetate Chemical Properties,Usage,Production

Synthesis

Glycine ethyl ester hydrochloride can be dissolved in a buffer solution composed of acetic acid and sodium acetate, and then dichloroethane is added as a solvent, and sodium nitrite solution is added dropwise at 10 to 15 ° C. After the dropwise addition, continue stirring for 15min. The separated organic layer is a dichloroethane solution of ethyl diazoacetate.
NH2CH2COOC2H5·HCl+NaNO2+HCl→N2CHCOOC2H5+NaCl+H2O

Chemical Properties

Liquid.

Uses

Reagent for ruthenium-catalyzed asymmetric cyclopropanation of alkenes.1

Uses

New Diazoacetate Formulations

Hazard

Flammable liquid that explodes when heated.

Safety Profile

Poison by ingestion and intravenous routes. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Can explode. Explodes on contact with tris(dimethy1amino) antimony. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.

Purification Methods

It is a very volatile yellow oil with a strong pungent odour. EXPLOSIVE [distillation even under reduced pressure is dangerous and may result in an explosion — TAKE ALL THE NECESSARY PRECAUTIONS IF DISTILLATION IS TO BE CARRIED OUT]. It explodes in contact with conc H2SO4-trace acid causes rapid decomposition. It is slightly soluble in H2O, but is miscible with EtOH, *C6H6, pet ether and Et2O. To purify, dissolve it in Et2O [using CH2Cl2 instead of Et2O, protects the ester from acid], wash it with 10% aqueous Na2CO3, dry (MgSO4), filter and repeat as many times as possible until the Et2O layer loses its yellow colour, then remove the solvent below 20o (vacuum). Note that prolonged heating may lead to rapid decomposition and low yields. It can also be purified by steam distillation under reduced pressure but with considerable loss in yield. Place the residual oil in a brown bottle, keep below 10o, and use as soon as possible without distilling. For preparing esters usually the ethereal solution is used directly without purification. [Womack & Nelson Org Synth Coll Vol III 392 1955, UV: Miller & White J Am Chem Soc 79 5974 1957, Fieser 1 367 1967, Beilstein 3 IV 1495.]

Ethyl diazoacetate Preparation Products And Raw materials

Raw materials

Buffer solution, pH 1.00 (±0.01 at 25°C), No Color, Specpure, NIST Traceable Glycine ethyl ester hydrochloride Permethric acid Ethyl acetate

Preparation Products

2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester Ethyl chrysanthemumate

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Ethyl diazoacetate Suppliers

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View Lastest Price from Ethyl diazoacetate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl diazoacetate 623-73-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: Ethyl diazoacetate 623-73-4
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-08-05

623-73-4, Ethyl diazoacetateRelated Search:

Ethylparaben Ethyl acrylate Ethyl acetate Ethanol Ethyl propiolate ISOXADIFEN-ETHYL Trinexapac-ethyl Ethyl cyanoacetate Ethyl Azidoacetate Ethyl phenylacetate Ethyl bromoacetate Pyridinium dichromate Diazolidinyl Urea bis(methoxycarbonyl)methylidene-imino-azanium ETHYL DIAZOACETOACETATE TERT-BUTYL DIAZOACETATE AZASERINE Ethyl 2-(4-bromophenyl)-2-diazoacetate

Acetic acid, diazo-, ethyl ester

Daae

Diazoacetic acid ethyl ester

Diazoacetic ester

diazoaceticacid,ethylester

diazo-aceticaciethylester

diazoaceticester

Diazoessigsaeure-aethylester

Ethoxycarbonyldiazomethane

Ethyl 2-diazoacetate

Ethyl diazoethanoate

ETHYL DIAZOACETATE

Ethylene Diazo Acetate

ETHYL DIAZOACETATE ETHYL DIAZOETHANOATE

2-Diazoacetic acid ethyl

Diazoacetic acid ethyl

Ethyl diazoate

Acetic acid, 2-diazo-,ethyl ester

Ethyl diazoacetate contains >=13 wt. % dichloroMethane

Ethyl diazoacetate solution, 95%

2-Diazoacetic acid ethyl ester solution

Ethyl diazoacetate solution,90% wt in dichloromethane

(e)-2-diazonio-1-ethoxyethenolate

Ethyl 2-diazoacetate (diluted with ~10% dichloromethane, wt/wt)

Ethyl diazoacetate, 95%, contains 5% CH2Cl2

diazoacetate soL

Ethyl Diazoacetate (&gt

Ethyl diazoacetate ISO 9001：2015 REACH

Ethyl Diazoacetate (>90%)

Ethyldiazoacetate, contains 15 wt. % dichloromethane

Ethyl diazoacetate 15% solution in DCM

Cilastatin Impurity 10

Tenofovir Disoproxil Fumarate Impurity 186

Ethyl diazoacetate, 80% solution in DCM

623-73-4

N2CHCOOC2H5

NNCHCOOC2H5

Azo/Diazo Compounds

Building Blocks

Nitrogen Compounds

Organic Building Blocks

Azo/Diazo Compounds

Building Blocks

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Carboxylic

Azo/Diazo Compounds

Nitrogen Compounds

Organic Building Blocks