ChemicalBook > CAS DataBase List > TENOVIN-1

TENOVIN-1

Product Name: TENOVIN-1
CAS No.: 380315-80-0
Chemical Name: TENOVIN-1
Synonyms: CS-571;TENOVIN-1;Tenovin-1, >=98%;TENOVIN-1 USP/EP/BP;TENOVIN-1;TENOVIN 1;Tenovin-1, p53 Activator;Tenovin-1, 10 mM in DMSO;N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
CBNumber: CB92446962
Molecular Formula: C20H23N3O2S
Formula Weight: 369.48
MOL File: 380315-80-0.mol

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TENOVIN-1 Property

Melting point:: >180°C (Subl.)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (10 mg/ml with warming)
pka: 9.09±0.70(Predicted)
form: solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

RIDADR: 3077
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 580566
Product name: Tenovin-1
Purity: A cell-permeable benzoylthiourea compound that acts as a reversible inhibitor of class III HDAC sirtuins against SirT2 (IC₅₀ = ~ 10 µM).
Packaging: 10 mg
Price: $86.7
Updated: 2025/07/31

TCI Chemical

Product number: T4345
Product name: Tenovin-1
Packaging: 10MG
Price: $132
Updated: 2025/07/31

TCI Chemical

Product number: T4345
Product name: Tenovin-1
Packaging: 50MG
Price: $360
Updated: 2025/07/31

Cayman Chemical

Product number: 13085
Product name: Tenovin-1
Purity: ≥98%
Packaging: 5mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 13085
Product name: Tenovin-1
Purity: ≥98%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

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TENOVIN-1 Chemical Properties,Usage,Production

Description

Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 μM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD⁺-dependent class III histone deacetylases that belong to the sirtuin family. While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.

Uses

Tenovin 1 is a sirtuin inhibitor.

Definition

ChEBI: N-[(4-acetamidoanilino)-sulfanylidenemethyl]-4-tert-butylbenzamide is a member of thioureas.

Biological Activity

p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21 CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro .

in vivo

Tenovin-1 (92 mg/kg, i.p.) reduces growth of tumors in SCID mice derived from BL2 cells or ARN8 cells^[5].

IC 50

MDM-2/p53; DHODH; Sirtuin

References

[1] SONIA LAIN. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.[J]. Cancer Cell, 2008, 13 5: 454-463. DOI:10.1016/j.ccr.2008.03.004
[2] J SONNEMANN. p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors[J]. British Journal of Cancer, 2013, 110 3: 656-667. DOI:10.1038/bjc.2013.742
[3] MINAKSHI NIHAL Gary S W Nihal Ahmad. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis.[J]. Cell Cycle, 2014, 13 4: 632-640. DOI:10.4161/cc.27523
[4] MELISSA J. WILKING . SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation[J]. Archives of biochemistry and biophysics, 2014, 563: Pages 94-100. DOI:10.1016/j.abb.2014.04.001
[5] CHRISTIAN MARX. The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line.[J]. Investigational New Drugs, 2018: 396-406. DOI:10.1007/s10637-017-0541-1
[6] MINJI BANG. Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes.[J]. Biomolecules & Therapeutics, 2019, 27 3: 283-289. DOI:10.4062/biomolther.2018.107

TENOVIN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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TENOVIN-1 Suppliers

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View Lastest Price from TENOVIN-1 manufacturers

Career Henan Chemical Co

Product: TENOVIN-1 380315-80-0
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

380315-80-0, TENOVIN-1Related Search:

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CS-571

TENOVIN-1

N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide

N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide

Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-

N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin 1

Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide

Tenovin-1, >=98%

TENOVIN-1;TENOVIN 1

TENOVIN-1 USP/EP/BP

Tenovin-1, p53 Activator

Tenovin-1, 10 mM in DMSO

380315-80-0

Inhibitor

Inhibitors