ChemicalBook > CAS DataBase List > 2-Chlorotoluene

2-Chlorotoluene

Product Name
2-Chlorotoluene
CAS No.
95-49-8
Chemical Name
2-Chlorotoluene
Synonyms
OCT;O-CHLOROTOLUENE;1-CHLORO-2-METHYLBENZENE;ortho-Chlorotoluene;2-Methylchlorobenzene;2,4-Dicyano-3-methylpentanediamide;OTF;2-Oct;POU2F;halso99
CBNumber
CB9245073
Molecular Formula
C7H7Cl
Formula Weight
126.58
MOL File
95-49-8.mol
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2-Chlorotoluene Property

Melting point:
-36 °C (lit.)
Boiling point:
157-159 °C (lit.)
Density 
1.083 g/mL at 25 °C (lit.)
vapor density 
4.38 (vs air)
vapor pressure 
10 mm Hg ( 43 °C)
refractive index 
n20/D 1.525(lit.)
Flash point:
117 °F
storage temp. 
0-6°C
solubility 
H2O: slightly soluble0.047g/L at 20°C
form 
Liquid
color 
Clear
explosive limit
1.0-12.6%(V)
Water Solubility 
slightly soluble
Merck 
14,2171
BRN 
1904175
Dielectric constant
4.4500000000000002
Exposure limits
ACGIH: TWA 50 ppm
NIOSH: TWA 50 ppm(250 mg/m3); STEL 75 ppm(375 mg/m3)
InChIKey
IBSQPLPBRSHTTG-UHFFFAOYSA-N
LogP
3.42 at 25℃
CAS DataBase Reference
95-49-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-chloro-2-methyl-(95-49-8)
EPA Substance Registry System
o-Chlorotoluene (95-49-8)
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Safety

Hazard Codes 
Xn,N,F,Xi,T
Risk Statements 
20-51/53-39/23/24/25-23/24/25-11
Safety Statements 
24/25-61-45-36/37-16-7
RIDADR 
UN 2238 3/PG 3
OEB
A
OEL
TWA: 50 ppm (250 mg/m3), STEL: 75 ppm (375 mg/m3)
WGK Germany 
2
RTECS 
XS9000000
Autoignition Temperature
600°C
Hazard Note 
Irritant/Flammable
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29036990
Hazardous Substances Data
95-49-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H332Harmful if inhaled

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
111910
Product name
2-Chlorotoluene
Purity
99%
Packaging
1kg
Price
$97.44
Updated
2025/07/31
Sigma-Aldrich
Product number
111910
Product name
2-Chlorotoluene
Purity
99%
Packaging
4kg
Price
$333
Updated
2025/07/31
TCI Chemical
Product number
C0295
Product name
2-Chlorotoluene
Packaging
25G
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
C0295
Product name
2-Chlorotoluene
Packaging
500G
Price
$64
Updated
2025/07/31
Sigma-Aldrich
Product number
111910
Product name
2-Chlorotoluene
Purity
99%
Packaging
100g
Price
$43.8
Updated
2025/07/31
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2-Chlorotoluene Chemical Properties,Usage,Production

Description

2-Chlorotoluene can be mineralized completely by Rhodococcus, strain OCT 10 DSM 45596(T). It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol. The oxidation of 2-chlorotoluene is very well catalyzed by the enzymes: toluene dioxygenase of P. putida F1 and chlorobenzene dioxygenase from Burkholderia, strain PS12.

Chemical Properties

o-Chlorotoluene is a flammable, colorless liquid with an aromatic odor.

Uses

Solvent and intermediate for organic chemicals and dyes.
2-Chlorotoluene is used for permanganate oxidation to give o-chlorobenzoic acid. It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol.
2-Chlorotoluene can be used as a precursor to synthesize aryl coupling products via palladium-catalyzed Negishi cross-coupling. It can also be used in the Buchwald-Hartwig amination to synthesize arylamines.

Uses

Solvent; synthesis of dyes, pharmaceuticals, and synthetic rubber compounds

Preparation

The solution of cuprous chloride is cooled in an ice bath 0-5° C temperature. In this cold solution, the 2-methylbenzenediazonium is poured with constant shaking and allowing the mixture to come to room temperature. After about 10 minutes, the mixture gradually warmed with a good shaking.As the temperature rises the brown addition product begins to decompose with the evolution of nitrogen and with the formation of an oily layer of 2-chlorotoluene. When the decomposition reaction is at an end, the mixture is steam distilled, continuing the process only as long as oily droplets are present in the distillate, for the product is not appreciably soluble in water. The layer of 2-chlorotoluene is carefully separated and washed twice with an equal volume of concentrated sulfuric acid, which removes both the 2-cresol and the azo compound. Then 2-chlorotoluene is washed with water in order to remove the inorganic acid. Finally, 2-chlorotoluene is dried over calcium chloride, distilled, using an air condenser and collecting the product boiling at 153-158° C. Pure 2-chlorotoluene boils at 157° C. The yield is 25-30 g.

Experiments in Organic Chemistry, L. F. Fieser, 216, 1941
Highly Selective Oxidative Monochlorination To Synthesize Organic Intermediates: 2-Chlorotoluene, 2-Chloroaniline, 2-Chlorophenol, and 2-Chloro-4-methylphenol

Synthesis Reference(s)

Journal of the American Chemical Society, 101, p. 768, 1979 DOI: 10.1021/ja00497a063
Organic Syntheses, Coll. Vol. 1, p. 170, 1941

General Description

Colorless liquid with an aromatic odor. Denser than water and poorly soluble in water. Hence sinks in water .

Air & Water Reactions

Slightly water soluble.

Reactivity Profile

2-Chlorotoluene may be incompatible with strong oxidizing and reducing agents. Also may be incompatible with amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Reacts violently with dimethyl sulfoxide .

Hazard

Toxic by inhalation. Eye, skin, and upper respiratory tract irritant.

Health Hazard

Inhalation of vapor may cause respiratory irrtation. Prolonged and repeated vapor exposures may produce systemic toxic effects.

Flammability and Explosibility

Flammable

Safety Profile

Moderately toxic by unspecified routes. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLE CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.

Potential Exposure

o-Chlorotoluene is widely used as a solvent and intermediate in the synthesis of dyes, synthetic rubber; pharmaceuticals; and other organic chemicals. Used as an insecticide, bactericide.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit

storage

Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with o-chlorotoluene you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area. Metal containersinvolving the transfer of this chemical should be groundedand bonded. Drums must be equipped with self-closingvalves, pressure vacuum bungs, and flame arresters. Useonly nonsparking tools and equipment, especially whenopening and closing containers of this chemical. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard.

Shipping

UN2238 Chlorotoluenes, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Dry 2-chlorotoluene for several days with CaCl2, then distil it from Na using a glass helices-packed column. [Beilstein 5 IV 805.]

Incompatibilities

Incompatible with acids, alkalis, oxidizers, reducing materials; water

Toxics Screening Level

The current ITSL for o-chlorotoluene (70 μg/m3) has a justification (attached) dated April 19,2001.

Waste Disposal

In accordance with 40CFR165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

2-Chlorotoluene Preparation Products And Raw materials

Raw materials

Toluene Chlorine o-Toluidine Copper(I) chloride Potassium iodide statch paper

Preparation Products

2-Chlorobenzotrifluoride 2-Chlorobenzotrichloride 2,4-Dichlorotoluene Chlorphoxim 2-Chlorophenylacetic acid Diclofenac sodium 2-Chlorobenzyl chloride 2-Chlorobenzoic acid Clotrimazole 2-Chlorobenzyl bromide 3-CHLOROBENZAL CHLORIDE 2-Chlorobenzaldehyde 4-Chlorotoluene
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2-Chlorotoluene Suppliers

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View Lastest Price from 2-Chlorotoluene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-chlorotoluene 95-49-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Shanghai Xin Cheng Yue Chemical Co.,Ltd
Product
2-Chlorotoluene 95-49-8
Price
US $0.00-0.00/kg
Min. Order
1000kg
Purity
99.8%
Supply Ability
100000ton
Release date
2024-01-26
Jinan Finer Chemical Co., Ltd
Product
2-Chlorotoluene 95-49-8
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
5000MT/year
Release date
2021-07-15

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