ChemicalBook > CAS DataBase List > N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

Product Name
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
CAS No.
881202-45-5
Chemical Name
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
Synonyms
CS-389;SerdeMetan;JNJ 26854165;JNJ-26854165, >=98%;Serdemetan(JNJ 26854165);JNJ-26854165 (SerdeMetan);JNJ 26854165; JNJ26854165; JNJ-26854165;N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine;N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-Benzene diamine;n-[2-(1h-indol-3-yl)ethyl]-n'-(4-pyridinyl)-1,4-benzenediamine
CBNumber
CB92484733
Molecular Formula
C21H20N4
Formula Weight
328.41
MOL File
881202-45-5.mol
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N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Property

storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO
form 
solid
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16259
Product name
JNJ-26854165
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16259
Product name
JNJ-26854165
Purity
≥98%
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
16259
Product name
JNJ-26854165
Purity
≥98%
Packaging
10mg
Price
$213
Updated
2024/03/01
Cayman Chemical
Product number
16259
Product name
JNJ-26854165
Purity
≥98%
Packaging
25mg
Price
$442
Updated
2024/03/01
TRC
Product number
J211343
Product name
JNJ26854165
Packaging
10mg
Price
$230
Updated
2021/12/16
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N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Chemical Properties,Usage,Production

Uses

JNJ 26854165 is a p53 activator and HDM2 ubiquitin ligase (MDM2) inhibitor.

Biological Activity

jnj-26854165, also named as serdemetan, is originally developed as an activator of p53, is now regarded as a novel oral human double minute-2 (hdm-2) ubiquitin ligase antagonist. it can increase the level of hdm-2 client proteins, such as p53, by inhibiting the association of hdm-2-client protein complex with the proteosome. it is demonstrated potent anti-proliferative and apoptosis-inducing activity of jnj-26854165 in a broad range of p53 wild type and mutant tumor models. in vivo, jnj-26854165 may induce important differences in efs distribution when comparing to control in 18 of 37 solid tumors and in 5 of 7 of the evaluable all xenografts.j. tabernero, l. dirix, p. schoffski, a. cervantes, j. capdevila, j. baselga, l. van beijsterveldt, h. winkler, s. kraljevic and s. h. zhuang. phase i pharmacokinetic (pk) and pharmacodynamic (pd) study of hdm-2 antagonist jnj-26854165 in patients with advanced refractory solid tumors. journal of clinical oncology (meeting abstracts) may 2009 vol. 27 no. 15s 3514malcolm a. smith, richard gorlick, e. anders kolb, richard lock, hernan carol, john m. maris, stephen t. keir, christopher l. morton, c. patrick reynolds, min h. kang, janine arts, tarig bashir, michel janicot, raushan t. kurmasheva, peter j. houghton. initial testing of jnj-26854165 (serdemetan) by the pediatric preclinical testing program. pediatric blood & cancer. volume 59, issue 2, pages 329–332, august 2012.

target

HDM2

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Suppliers

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View Lastest Price from N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine 881202-45-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
Dideu Industries Group Limited
Product
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine 881202-45-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-11
Career Henan Chemical Co
Product
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine 881202-45-5
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

881202-45-5, N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamineRelated Search:

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  • N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
  • CS-389
  • JNJ 26854165; JNJ26854165; JNJ-26854165
  • JNJ 26854165
  • SerdeMetan
  • JNJ-26854165 (SerdeMetan)
  • JNJ 26854165 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
  • N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine JNJ 26854165
  • JNJ-26854165, >=98%
  • N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-Benzene diamine
  • Serdemetan(JNJ 26854165)
  • 1,4-Benzenediamine, N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-
  • N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine ISO 9001：2015 REACH
  • n-[2-(1h-indol-3-yl)ethyl]-n'-(4-pyridinyl)-1,4-benzenediamine
  • 881202-45-5
  • Inhibitors
  • Inhibitor